Globally, Sexually Transmitted Infections have become a public health concern as it is threatening people’s sexual and reproductive health. Both current and previous researches agree that STIs are a threat to societal wellbeing; hence need serious intervention. The purpose of this study was to identify factors that influence the prevalence of STIs among the Maasai of Ilkeekonyokie ward in Kajiado County within Kenya. The multistage sampling technique and convenient sampling procedures were applied to get a sample size of 100 respondents in Kajiado West. The sample size was justifiable as multinomial logistic regressions requires a minimum of 10 cases per independent variable (Schwab, 2002). The researcher used structured questionnaire to collect data from the respondents. Thereafter, the data were analyzed using SPSS (Vs 26). The study used the Multinomial Logistic Regression model to examine the prevalence of STIs in Ilkeekonyokie ward. Results from the study indicate that Maasai attitude dimensions explained in cultural attitudes toward sexuality, town job seeking, engagement in cattle business, and urbanization are related to the prevalence of Sexually Transmitted Infections in Ilkeekonyokie ward.