We study D \mathcal {D} -modules and related invariants on the space of 2 × 2 × n 2\times 2\times n hypermatrices for n ≥ 3 n\geq 3 , which has finitely many orbits under the action of G = G L 2 ( C ) × G L 2 ( C ) × G L n ( C ) G=GL_2(\mathbb {C}) \times GL_2(\mathbb {C}) \times GL_n(\mathbb {C}) . We describe the category of coherent G G -equivariant D \mathcal {D} -modules as the category of representations of a quiver with relations. We classify the simple equivariant D \mathcal {D} -modules, determine their characteristic cycles and find special representations that appear in their G G -structures. We determine the explicit D \mathcal {D} -module structure of the local cohomology groups with supports given by orbit closures. As a consequence, we calculate the Lyubeznik numbers and intersection cohomology groups of the orbit closures. All but one of the orbit closures have rational singularities: we use local cohomology to prove that the one exception is neither normal nor Cohen–Macaulay. While our results display special behavior in the cases n = 3 n=3 and n = 4 n=4 , they are completely uniform for n ≥ 5 n\geq 5 .