Lymphoma-like Lesions Research Articles

Parasitological and clinico-pathological profiles in friesian cattle naturally infected with Theileria annulata in Saudi Arabia.

Clinico-pathological profiles were studied in adult and young Friesian cattle naturally infected with Theileria annulata in the Qassim Region, Saudi Arabia. Sixty-two clinical cases of T. annulata infection in adult and young Friesian cattle were diagnosed during the period from August 1999 to July 2000. Symptoms observed were marked fever, swelling of superficial lymph nodes, inappetance, tachycardia, dyspnoea and weakness. The most prominent gross pathological features were jaundice, petechial and ecchymotic haemorrhages involving mucosal and serosal surfaces of many organs as well as body fat. A number of young and adult Friesian cattle undergoing lethal T. annulata infection developed lymphoma-like lesions in a manner similar to that of T. parva. The main histological findings were necrosis and severe lymphocytic infiltration. The spleen, lymph nodes and Peyer's patches were devoid of typical lymph nodules.

Lymphoma-like lesion of the uterine cervix

Lymphoma-like lesion of the uterine cervix is a benign reactive lymphoid hyperplasia associated with chronic cervicitis that may pose a problem in differential diagnosis from malignant lymphoma. It is a rare entity and only about 20 cases have been reported in the world literature. Two cases of cervical lymphoma-like lesion are described. In both patients, the diagnosis was based on microscopic examination of biopsies taken from the uterine cervix. One patient subsequently had a cervical conization that confirmed the diagnosis of lymphoma-like lesion. Both patients are well, alive and with no evidence of malignant lymphoma. It is concluded that the diagnosis of lymphoma-like lesion is based on the well-established characteristic microscopic features of this lesion. Immunohistochemical staining is usually not helpful in distinguishing this lesion from malignant lymphoma. No specific treatment is necessary for this condition.

11 Animal models and vaccine development

Following the demonstration of Helicobacter pylori as a major gastroduodenal pathogen there was a need to develop animal models in order to investigate mechanisms of pathogenesis and to be able to test new treatment strategies. Helicobacter pylori will only colonize a limited number of hosts including non-human primates, germ-free or barrier raised piglets, germ-free dogs and recently laboratory raised cats. Although these models have proved useful there is a need for more convenient small animal models. The ferret infected with its natural gastric organism, Helicobacter mustelae, is the only other animal to show peptic ulceration and has been successfully used to investigate gastritis and antimicrobial agents. The other commonly used animal model is the laboratory mouse or rat infected with either Helicobacter fells or Helicobacter heilmannii, bacteria that normally colonize cat or dog gastric mucosae. Active/chronic gastritis, gastric atrophy, and lymphoma-like lesions have been shown to develop in H. felis infected mice. The most recent and exciting use of an animal model has been the use of the H. felis mouse model in the development of human vaccines against H. pylori. Mice can be protected against infection with large doses of viable H. felis by oral immunization using sonicates of H. felis or H. pylori or recombinant H. pylori urease together with cholera toxin or cholera toxin-B subunit as the mucosal adjuvant. More importantly it has been shown that immunization of already infected animals results in eradication of infection. This raises the intriguing possibility that therapeutic immunization might be a viable option in the management of Helicobacter-associated disease. If immunization as a therapy of peptic ulcers was combined with short-term acid suppression, the possibility of reinfection may also be eliminated. In those countries where H. pylori infection rates are very high and infection occurs at all early age, large scale oral immunization of sections of the community would not only protect the young from the deleterious consequences of long-term H. pylori infection but could also cure existing disease.

Detection of epstein-barr virus DNA from a lymphoma-like lesion of the uterine cervix

International Journal of Gynecology & ObstetricsVolume 41, Issue 1 p. 111-111 Citations from the literature infectious diseases Detection of epstein-barr virus DNA from a lymphoma-like lesion of the uterine cervix T Hachisuga, T HachisugaSearch for more papers by this authorY Ookuma, Y OokumaSearch for more papers by this authorK Fukuda, K FukudaSearch for more papers by this authorT Iwasaka, T IwasakaSearch for more papers by this authorH Sugimori, H SugimoriSearch for more papers by this authorT Watanabe, T WatanabeSearch for more papers by this author T Hachisuga, T HachisugaSearch for more papers by this authorY Ookuma, Y OokumaSearch for more papers by this authorK Fukuda, K FukudaSearch for more papers by this authorT Iwasaka, T IwasakaSearch for more papers by this authorH Sugimori, H SugimoriSearch for more papers by this authorT Watanabe, T WatanabeSearch for more papers by this author First published: April 1993 https://doi.org/10.1016/0020-7292(93)90175-VAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume41, Issue1April 1993Pages 111-111 RelatedInformation

Detection of Epstein-Barr virus DNA from a lymphoma-like lesion of the uterine cervix

The case of a 60-year-old woman in whom a lymphoma-like lesion of the cervix was found during an episode of silent Epstein-Barr virus (EBV) infection is presented. Fractional curettage was performed because of abnormal endometrial smear. The endocervical curettage specimens were diagnosed as highly suggestive of malignant lymphoma, but microscopic examination of a subsequent hysterectomy specimen revealed a benign lymphoid hyperplasia. Those were retrospectively interpreted as a lymphomalike lesion of the cervix. In the absence of clinical symptoms of infectious mononucleosis, the results of serologic tests for EBV revealed an active EBV infection. EBV DNA was demonstrated in nuclei of large lymphoid cells in endocervical curettage specimens by in situ hybridization. She is alive and well 32 months postoperatively. When female patients with lymphoma-like lesions of the lower genital tract are encountered, examinations for EBV are recommended.

Lymphoma-like lesions induced in the hamster cheek pouch with topical vitamin A palmitate.

Lymphoma-like lesions induced in the hamster cheek pouch with topical vitamin A palmitate.