To assess the ability of prenatal prognostic markers to predict the postnatal outcome in fetuses diagnosed with congenital diaphragmatic hernia (CDH). Retrospective study of fetuses diagnosed with CDH between 2006-2016 at a tertiary care referral centre. Following prenatal prognostic markers were analysed: lung-to-head ratio (LHR), observed-to-expected LHR (O/E-LHR), right CDH, liver herniation (LH), associated congenital anomalies/chromosomopathies, and gestational age (GA) at diagnosis. We compared these parameters with the postnatal outcome [pulmonary hypertension (PH), need for extracorporeal membrane oxygenation (ECMO), survival at discharge and survival at 6 months of life]. Diagnosis of CDH was established in 54 cases of CDH. Twenty-six cases were excluded because of termination of pregnancy (TOP). One of them, at the time of the study, the newborn was still admitted to the Pediatric Intensive Care Unit, with one month of life. Of the remaining 27 cases and according to the postnatal outcome, 52.6% (10/19) developed PH, 87.5% (21/24) needed ECMO, 55.6% (15/27) survived at hospital discharge and 48.1% (13/27) survived at 6 months of life. No differences in the prognostic markers were found regarding to PH and need for ECMO after birth. Those patients who did not survive at discharge and at 6 months of life had a significantly higher rate of LHR <1 (86% vs. 14%, p=0.033 and 100% vs. 0%, p=0.007, respectively) and LH (69% vs. 31%, p=0.017 and 77% vs. 23%, p=0.016). No survivors at 6 months of life were also significantly earlier diagnosed (23.6±6 vs. 28.3±6, p=0.048) and had more frequently associated anomalies (80% vs. 20%, p=0.021). We did not find any differences for the remaining prognostic markers regarding survival at discharge neither at 6 months of life. Prognostic markers associated with a poorer postnatal outcome were early GA at diagnosis, LH, LHR<1 and associated anomalies. These data are according to reported.