The lubrication status of crankshaft main bearings significantly affects the stability and reliability of diesel engine operation. This paper primarily investigates the severe failure of main bearings during developing an industrial high-power 6 V diesel engine and analyzes the causes of bearing failure. Main bearings using lemon-shaped bearing shells exhibited failure after a short period of operation. Based on the multi-body dynamics model, average Reynolds equation, and contact model, a lubrication model for the main bearings was established, and the lubrication characteristics of each main bearing were simulated. The research shows that the abrupt peaks of the lemon-shaped bearing shells on the first and second main bearings are located within the area where the bearings suffer from burst pressure, resulting in additional hydrodynamic pressure and asperity contact pressure on the bearing surfaces. This makes the bearing surface prone to wear and high temperature, which are the primary causes of bearing failure. Under the operating conditions, surface damage of the bearings leads to particle abrasion and high temperature. Subsequently, the lubricating oil gradually deteriorates with the combined action of high temperature and wear particles, causing the main bearings to blacken and adhesive wear.