Summary Various types of temporary plugging agents are used in hydraulic fracturing to promote the uniform propagation of multicluster hydraulic fractures and increase the complexity of hydraulic fractures. However, the plugging behavior of these agents in hydraulic fractures has not yet been fully clarified, making the optimization of temporary plugging formulas challenging. In this study, dozens of plugging experiments were carried out to reveal the plugging behavior of pure fiber, pure particle, and fiber-particle combination materials in hydraulic fractures. The results indicate that the high fiber concentration and long fibers are beneficial to obtaining high maximum plugging pressures. However, the low tensile strength of fibers makes it difficult to form stable plugging layers under high pressure, especially for wide fractures. For particle plugging agents, the high rigidity of the particles prevents them from compacting tightly within the plugging layer, resulting in high permeability and low temporary plugging pressure. Excessive particle diameter and concentration tend to cause rapid blockage at the fracture entrance, leading to poor plugging performance. In contrast, the fiber-particle composite plugging scheme can form a stable and tight plugging layer at lower concentrations of both fibers and particles. Moreover, replacing single-size particles in composite with multisize particles can further enhance the plugging effect, allowing for a higher plugging pressure with a lower dosage of temporary plugging agents. Comprehensively considering the effects of material concentration and size on the plugging effect, the critical plugging quantitative characterization equations for pure fiber, pure particle, and fiber-particle combination plugging schemes are established respectively, with fracture width as the independent variable and the product of material concentration and size as the dependent variable. The temporary plugging schemes for various hydraulic fracture widths can be preliminarily determined using these equations. Based on the principle of economic optimization, the optimal temporary plugging schemes with consideration of the plugging pressure requirements were selected, which have shown good field application performance.