Abstract Background: Tobacco products cause about 1 in 5 deaths premature deaths each year. §Cancer patient survival increases approximately 30% with effective tobacco cessation intervention. Tobacco use post cancer can disrupt treatment plans including surgery delay, negatively affect treatment response, and the benefits of quitting are well-documented including accelerated healing and improved quality of life and well-being.Racial and ethnic minorities are adversely targeted by tobacco industry resulting in high tobacco use and tobacco related disease burden. With increased retailing of both tobacco and electronic nicotine delivery systems (ENDS) products, cancer centers such as City of Hope are prioritizing tobacco and ENDS control. Method: The cancer center expanded the current cessation program by: 1. Building a robust Patient EHR Tobacco Registry capturing tobacco use/exposure of cancer patients; 2. Establishing sustainable IT facilitated clinical workflow for timely and comprehensive tobacco use assessment with accompanying cessation intervention for both high-risk recent quitters and current tobacco users and facilitate basic, behavioral and clinical studies. We conducted formative geospatial analyses of dedicated smoke and vape shops linked to neighborhood demographic characteristics. The objective of the study was to analyze local data on smoke and vaping shop locations by age, socio-economic status, and racial/ethnic group. Our geospatial analysis used aggregate data from the U.S. Census, Google Maps, and Yelp. Geospatial maps were created using ArcGIS Pro with American Community Survey and U.S. Census 2010. The distributions of exclusive tobacco and vaping shop locations data were overlaid with data from the U.S. Census 2010 to generate maps of the relative geographic distributions of shops across varying area demographic characteristics. Results: In the COH network that includes community clinical sites, there are variations in tobacco use by geographic regions showed that a higher concentration of exclusive smoke and vaping shops were in areas with a higher concentration of ethnic minorities and lower income and lower status neighborhoods. Conclusion: Tobacco use is influenced by societal determinants of health (SDH) with minoritized populations having greater exposure to tobacco products that brings greater smoking rates. Tobacco cessation is a quality care issue, and a health equity and justice issue. Allocations of resources must account for the metrics of tobacco use and be responsive to both patient characteristics and community factors. Tobacco control services and research for cancer patients ought to be conducted in partnership with cancer care team. A multidisciplinary research can provide multilevel data accounting for the intersection of SDH and community level factors (e.g. density of tobacco retail, environmental exposure) with biological factors. Cancer Centers' sustainable tobacco control must involve community engagement, team science, clinical and care coordination and policy action Citation Format: Kimlin Ashing, Cary Presant, Sophia Yeung, Jonjon Macalintal, Brian Tiep, Argelia Sandoval, Dan Raz, Ravi Salgia, Loretta Erhunmwunsee, Arya Amini, Amar Merla, Heather Graves, Steven Rosen. Spatial and descriptive analysis of smoke and vape shop locations focusing on a cancer center neighboring catchment area [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-273.