Objective: To evaluate clinical and neurophysiological manifestation in association with onconeural antibodies among patients with lymphoproliferative disorders. Background Lymphoproliferative disorders are recognized among important causes of paraneoplastic neurological syndromes (PNS). Subacute sensory neuropathy is the most frequents typical PNS, however other types of neuropathy are also observed. Systemic studies in homogenous group of patients with malignancies have not been conducted. Design/Methods: The study included in 25 patients with lymphoproliferative disorders: 8 lymphoma cases (32%), 13 myeloma (52%) and 4 leukemia ones 16%). According to the examination protocol, routine electromyographic examinations were carried out, and onconeuronal antibodies were evaluated by means of indirect immunofluorescence as a screening test and Western blotting for confirmation. Results: Symptoms of sensory-motor polyneuropathy were found in 36%, sensory polyneuropathy in 28%, and mononeuropathy in 8% of patients. Autoimmune reaction limited to anti-Myelin Associated Glycoprotein antibodies were detected in 16% of cases. In patients with abnormalities in neurological examination following neurophysiological findings were observed: reduction of amplitude of responses from motor fibres in the ulnar nerve (P=0.005), increased polyphasy in the right interossalis muscle (P=0.023) and right dorsiflexor (P=0.022) in comparison with subjects without clinical deficit. In lymphoma patients nerve conduction was decreased (P=0.041) when compared with myeloma patients, and the Motor Unit Action Potential (MUAP) in right tibial anterior was prolonged in myeloma cases (P = 0.029). Moreover, a proportion of MUAP polyphasy (r=-0.4624; P=0.0200) and amplitude of response from sensory fibers of median (r=-0.4149; P=0.0490) and ulnar nerve (r=- 0.5403; P=0.0139) correlated with the duration of chemotherapy. Conclusions: Sensory disorders are dominant among patients with lymphoproliferative disorders, clinically manifest as sensory or sensory-motor polyneuropathy, and neurophysiological examination reveals axonal changes. In subjects with lymphoma the neurophysiological disorders in peripheral nerves of lower limbs are significantly more advanced than in myeloma cases. Disclosure: Dr. Rogoziewicz has nothing to disclose. Dr. Wiszniewska has nothing to disclose. Dr. Wiszniewski has nothing to disclose. Dr. Michalak has nothing to disclose. Dr. Kozubski has nothing to disclose.