Chrysoperla carnea (Neuroptera: Chrysopidae) is an attractive biological control option for various insect pests. Buprofezin is commonly used to control insect pests of economic importance in crops where this natural enemy is present. In this study, a Field Strain of C. carnea was collected, assayed and selected with buprofezin to determine resistance development potential. After 8 generations of laboratory selection, C. carnea developed 392.37-fold and 16.16-fold resistance when compared to susceptible and Field Strains, respectively. Very low cross-resistance to pyriproxyfen (3.24-fold) and acetamiprid (5.38-fold) was observed in Bupro-SEL Strain when compared to Field Strains but cross-resistance to spinosad (3.21-fold) was negative. High realized heritability (h2 = 0.49) value was observed in selected strain after 8 generations. Enzyme inhibitors (PBO & DEF) expressively reduced buprofezin resistance in resistant strain showing involvement of microsomal oxidases and esterases. These results show survival potential of C. carnea in cropping environment where insecticides are commonly employed.