Malaria affects millions of people every year, especially in our world. The main treatments are oral antibiotics and vaccines. The rise of the malaria parasite, now resistant to most anti-viral drugs, is causing a global crisis. Furthermore, low water solubility and permeability of both new and old antibiotics cause limited oral bioavailability and non-compliance from patients. Lipid formulations are frequently employed to lessen toxicity, boost solubility, and improve effectiveness. The findings of studies on oral-specific lipophilic drug delivery systems, such as self-emulsifying drug delivery systems, are reviewed in this article. (SEDDS). SEDDS increases the absorption of anti-inflammatory drugs by promoting the formation of liquid emulsions that dissolve the drug in the intestine. However, traditionally used SEDDS are usually in liquid form, administered into the oral cavity, and have poor safety. This article discusses a new solidification process that can be easily and economically scaled up by using existing equipment. This strategy might also increase patient compliance and product stability. Oral SEDDS has a substantial potential influence in the fight against malaria.