The potential hazards resulting from a low-velocity impact (bird-strike, tool drop, runway debris, etc.) on aircraft structures, such as engine nacelle or a leading edge, has been a long-term concern to the aircraft industry. Certification authorities require that exposed aircraft components must be tested to prove their capability to withstand low-velocity impact without suffering critical damage. This paper describes the results from experimental and numerical simulation studies on the impact and penetration damage of a sandwich panel by a solid, round-shaped impactor. The main aim was to prove that a correct mathematical model can yield significant information for the designer to understand the mechanism involved in the low-velocity impact event, prior to conducting tests, and therefore to design an impact-resistant aircraft structure. Part of this work presented is focused on the recent progress on the materials modelling and numerical simulation of low-velocity impact response onto a composite aircraft sandwich panel. It is based on the application of explicit finite element (FE) analysis codes to study aircraft sandwich structures behaviour under low-velocity impact conditions. Good agreement was obtained between numerical and experimental results, in particular, the numerical simulation was able to predict impact damage and impact energy absorbed by the structure.