U.S. freight railroads consume in excess of 13 billion liters of diesel fuel yearly. Although efforts to improve energy efficiency and reduce emissions have made substantial progress in the last decades, the benefits are relatively incremental and will not be sufficient to realize full decarbonization. Several independent efforts are underway to develop alternative locomotive fuels and propulsion technologies designed to fit within the typical locomotive envelope. In addition to these more conventional efforts, multiple startup companies are working to develop self-propelled autonomous railcars (SPARCs) that can achieve targeted decarbonization levels while also disrupting the traditional railroad operating paradigm. SPARC operations with multiple platoon lengths, as well as a control scenario with a conventional train length of 110 railcars, were simulated on an example corridor linking a port with an inland intermodal terminal. This line was single track with short sidings on inconsistent intervals, which is typical of U.S. branch lines serving few local customers without heavy through traffic. For all traffic levels simulated, SPARCs had a much lower transit time than the conventional trains. Optimal platoon length varied between 15- and 38-vehicles per platoon depending on the traffic demand, well under North American standards of over 100 railcars per train.