Low Tone Research Articles

High vagally mediated resting-state heart rate variability is associated with superior working memory function.

Heart rate variability (HRV), a cardiac vagal tone indicator, has been proven to predict performance on some cognitive tasks that rely on the prefrontal cortex. However, the relationship between vagal tone and working memory remains understudied. This study explores the link between vagal tone and working memory function, combined with behavioral tasks and functional near-infrared spectroscopy (fNIRS). A total of 42 undergraduate students were tested for 5-min resting-state HRV to obtain the root mean square of successive differences (rMSSD) data, and then divided into high and low vagal tone groups according to the median of rMSSD data. The two groups underwent the n-back test, and fNIRS was used to measure the neural activity in the test state. ANOVA and the independent sample t-test were performed to compare group mean differences, and the Pearson correlation coefficient was used for correlation analysis. The high vagal tone group had a shorter reaction time, higher accuracy, lower inverse efficiency score, and lower oxy-Hb concentration in the bilateral prefrontal cortex in the working memory tasks state. Furthermore, there were associations between behavioral performance, oxy-Hb concentration, and resting-state rMSSD. Our findings suggest that high vagally mediated resting-state HRV is associated with working memory performance. High vagal tone means a higher efficiency of neural resources, beneficial to presenting a better working memory function.

Metabolic and Molecular Response to High-Fat Diet Differs between Rats with Constitutionally High and Low Serotonin Tone.

Maintaining energy balance is a complex physiological function whose dysregulation can lead to obesity and associated metabolic disorders. The bioamine serotonin (5HT) is an important regulator of energy homeostasis, with its central and peripheral pools influencing energy status in opposing ways. Using sublines of rats with constitutionally increased (high-5HT) or decreased (low-5HT) whole-body 5HT tone, we have previously shown that under standard diet constitutionally higher 5HT activity is associated with increased body weight, adiposity, and impaired glucose homeostasis. Here, we investigated the response of 5HT sublines to an obesogenic diet. Consistent with previous findings, high-5HT animals fed a standard diet had poorer metabolic health. However, in response to a high-fat diet, only low-5HT animals increased body weight and insulin resistance. They also showed more pronounced changes in blood metabolic parameters and the expression of various metabolic genes in hypothalamus and adipose tissue. On the other hand, high-5HT animals appeared to be protected from major metabolic disturbances of the obesogenic diet. The results suggest that constitutionally low 5HT activity is associated with higher susceptibility to harmful effects of a high-energy diet. High-5HT subline, which developed less adverse metabolic outcomes on hypercaloric diets, may prove useful in understanding metabolically healthy obesity in humans.

Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages.

Necrostatin-1 blocks ferroptosis via an unknown mechanism and necroptosis through inhibition of receptor-interacting protein kinase-1 (RIP1). We report that necrostatin-1 suppresses cyclooxygenase-2-dependent prostaglandin biosynthesis in lipopolysaccharide-treated RAW264.7 macrophages (IC50 ∼ 100 μM). This activity is shared by necrostatin-1i (IC50 ∼ 50 μM), which lacks RIP1 inhibitory activity, but not the RIP1 inhibitors necrostatin-1s or deschloronecrostatin-1s. Furthermore, we show that the potent ferroptosis inhibitors and related compounds ferrostatin-1, phenoxazine, phenothiazine, and 10-methylphenothiazine strongly inhibit cellular prostaglandin biosynthesis with IC50's in the range of 30 nM to 3.5 μM. None of the compounds inhibit lipopolysaccharide-mediated cyclooxygenase-2 protein induction. In the presence of activating hydroperoxides, the necrostatins and ferroptosis inhibitors range from low potency inhibition to stimulation of in vitro cyclooxygenase-2 activity; however, inhibitory potency is increased under conditions of low peroxide tone. The ferroptosis inhibitors are highly effective reducing substrates for cyclooxygenase-2's peroxidase activity, suggesting that they act by suppressing hydroperoxide-mediated activation of the cyclooxygenase active site. In contrast, for the necrostatins, cellular prostaglandin synthesis inhibition does not correlate with peroxidase-reducing activity but rather with the presence of a thiohydantoin substituent, which conveys the ability to reduce the endoperoxide intermediate prostaglandin H2 to prostaglandin F2α in vitro. This finding suggests that necrostatin-1 blocks cellular prostaglandin synthesis and ferroptosis via a redox mechanism distinct from action as a one-electron donor. The results indicate that a wide range of compounds derived from redox-active chemical scaffolds can block cellular prostaglandin biosynthesis.

A Novel Low Complexity Two-Stage Tone Reservation Scheme for PAPR Reduction in OFDM Systems.

Orthogonal frequency division multiplexing (OFDM) has the characteristics of high spectrum efficiency and excellent anti-multipath interference ability. It is the most popular and mature technology currently in wireless communication. However, OFDM is a multi-carrier system, which inevitably has the problem of a high peak-to-average power ratio (PAPR), and s signal with too high PAPR is prone to distortion when passing through an amplifier due to nonlinearity. To address the troubles caused by high PAPR, we proposed an improved tone reservation (I-TR) algorithm to alleviate the above native phenomenon, which will pay some modest pre-calculations to estimate the rough proportion of peak reduction tone (PRT) to determine the appropriate output power allocation threshold then utilize a few iterations to converge to the near-optimal PAPR. Furthermore, our proposed scheme significantly outperforms previous works in terms of PAPR performance and computational complexity, such as selective mapping (SLM), partial transmission sequence (PTS), TR, tone injection (TI), etc. The simulation results show that in our proposed scheme, the PAPR is appreciably reduced by about 6.44 dB compared with the original OFDM technique at complementary cumulative distribution function (CCDF) equal to 10-3, and the complexity of I-TR has reduced by approximately 96% compared to TR. Besides, as for bit error rate (BER), our proposed method always outperforms the original OFDM without any sacrifice.

Clinical features and genetic analysis of two Chinese pedigrees affected with Joubert syndrome

To explore the clinical characteristics and genetic basis of two Chinese pedigrees affected with Joubert syndrome. Clinical data of the two pedigrees was collected. Genomic DNA was extracted from peripheral blood samples and subjected to high-throughput sequencing. Candidate variants were verified by Sanger sequencing. Prenatal diagnosis was carried out for a high-risk fetus from pedigree 2. The proband of pedigree 1 was a fetus at 23+5 weeks gestation, for which both ultrasound and MRI showed "cerebellar vermis malformation" and "molar tooth sign". No apparent abnormality was noted in the fetus after elected abortion. The fetus was found to harbor c.812+3G>T and c.1828G>C compound heterozygous variants of the INPP5E gene, which have been associated with Joubert syndrome type 1. The proband from pedigree 2 had growth retardation, mental deficiency, peculiar facial features, low muscle tone and postaxial polydactyly of right foot. MRI also revealed "cerebellar dysplasia" and "molar tooth sign". The proband was found to harbor c.485C>G and c.1878+1G>A compound heterozygous variants of the ARMC9 gene, which have been associated with Joubert syndrome type 30. Prenatal diagnosis found that the fetus only carried the c.485C>G variant. A healthy infant was born, and no anomalies was found during the follow-up. The compound heterozygous variants of the INPP5E and ARMC9 genes probably underlay the disease in the two pedigrees. Above finding has expanded the spectrum of pathogenic variants underlying Joubert syndrome and provided a basis for genetic counseling and prenatal diagnosis.

Neurophysiological and emotional influences on team communication and metacognitive cyber situational awareness during a cyber engineering exercise.

Background: Cyber operations unfold at superhuman speeds where cyber defense decisions are based on human-to-human communication aiming to achieve a shared cyber situational awareness. The recently proposed Orient, Locate, Bridge (OLB) model suggests a three-phase metacognitive approach for successful communication of cyber situational awareness for good cyber defense decision-making. Successful OLB execution implies applying cognitive control to coordinate self-referential and externally directed cognitive processes. In the brain, this is dependent on the frontoparietal control network and its connectivity to the default mode network. Emotional reactions may increase default mode network activity and reduce attention allocation to analytical processes resulting in sub-optimal decision-making. Vagal tone is an indicator of activity in the dorsolateral prefrontal node of the frontoparietal control network and is associated with functional connectivity between the frontoparietal control network and the default mode network. Aim: The aim of the present study was to assess whether indicators of neural activity relevant to the processes outlined by the OLB model were related to outcomes hypothesized by the model. Methods: Cyber cadets (N = 36) enrolled in a 3-day cyber engineering exercise organized by the Norwegian Defense Cyber Academy participated in the study. Differences in prospective metacognitive judgments of cyber situational awareness, communication demands, and mood were compared between cyber cadets with high and low vagal tone. Vagal tone was measured at rest prior to the exercise. Affective states, communication demands, cyber situational awareness, and metacognitive accuracy were measured on each day of the exercise. Results: We found that cyber cadets with higher vagal tone had better metacognitive judgments of cyber situational awareness, imposed fewer communication demands on their teams, and had more neutral moods compared to cyber cadets with lower vagal tone. Conclusion: These findings provide neuroergonomic support for the OLB model and suggest that it may be useful in education and training. Future studies should assess the effect of OLB-ing as an intervention on communication and performance.

Analyses Related to the Hearing

I intend to present a few interesting issues for analysis: We deliver a 20 dB 100 Hz tone for 20 milliseconds. The ear receives it; a low tone has to be enhanced, since such a signal energy is too weak to reach the centre. There are doubts whether here active is only a mechanical amplification through an OHC contraction.

Is perfusion index a surrogate indicator of left ventricular contractility in neonates? A prospective study.

Noninvasive blood pressure monitoring may not accurately reflect cardiac contractility in neonates due to low vascular tone. The perfusion index (PI) is a noninvasive method of assessing the strength of peripheral pulses. It is shown to have a significant correlation with the left ventricular output. This prospective study estimates the correlation between PI and cardiac contractility in neonates. All hemodynamically stable neonates who were on substantial enteral feeds and not on any respiratory or inotropic support underwent measurement of PI and echocardiography examination. Various indices of left ventricular contractility were estimated, and the correlation coefficient between them and PI was determined. Fifty-six neonates were studied. The median (interquartile range [IQR]) PI was 1.5 (1.25-1.75). The median (IQR) PI in preterm neonates was 1.5 (1.2-1.8) and that in term neonates was 1.8 (1.25-2.7) (P = 0.064). PI had a correlation of 0.205 with fractional shortening (P = 0.129) and 0.13 with left ventricular ejection fraction (P = 0.821). The Spearman's correlation coefficient between PI and velocity of circumference fiber shortening was 0.009 (P = 0.945). The Spearman's correlation coefficient between PI and cardiac output was -0.115 (P = 0.400). The PI does not correlate with left ventricular contractility parameters in neonates.

Composite wing vibration coupling control

The paper discusses the possibility to control coupled bending-twisting vibrations of composite wing by means of the monoclinic structures in the reinforcement of the plating. Decomposing the potential straining energy and kinetic energy of natural vibration modes into interacting and non-interacting parts, it became possible to introduce the two coefficients that integrally consider the effect of geometry and reinforcement structure upon the dynamic response parameters of the wing. The first of these coefficients describes the elastic coupling of the natural vibration modes, the second coefficient describes the inertial one. The paper describes the numerical studies showing how the orientation of considerably anisotropic CRP layers in the plating affects natural frequencies, loss factors, coefficients of elastic and inertial coupling for several lower tones of natural bending-twisting vibrations of the wing. Besides, for each vibration mode, partial values of the above mentioned dynamic response parameters were determined by means of the relationships for orthotropic structures where instead of “free” shearing modulus in the reinforcement plant, “pure” shearing modulus is used. Joint analysis of the obtained results has shown that each pair of bendingtwisting vibration modes has its orientation angle ranges of the reinforcing layers where the inertial coupling caused by asymmetry of the cross-section profile with respect to the main axes of inertia decreases, down to the complete extinction, due to the generation of the elastic coupling in the plating material. These ranges are characterized by the two main features: 1) the difference in the natural frequencies of the investigated pair of bendingtwisting vibration modes is the minimum and 2) natural frequencies of bending-twisting vibrations belong to a stretch restricted by corresponding partial natural frequencies of the investigated pair of vibration modes. This result is of practical importance because it enables approximate analysis of real composite wings with complex geometry in the existing commercial software packages.

Phonology of Kafi Noonoo ideophones

This paper is the first and original work on the phonology of Kafi Noonoo ideophones. All of the data used in this study are collected through fieldwork. Ideophones are attested word classes with peculiar phonology in that they break some phonological rules of the prosaic language. Kafi Noonoo ideophones also undergo unique phonological features from the regular phonology of the language. Kafi Noonoo ideophones use all the phonemes of the regular language and additional five click-like sounds (ʘ, ǃ, ǁ, ʞ, and tchip). The click-like sounds do not found in the language and the regular phonology of Ethiopian Afro-Asiatic languages in general. Kafi Noonoo ideophones show different suprasegmental features from the regular phonology of the language. Another striking phonological feature in ideophones of the language is that ideophones break the phonotactics and suprasegmental features rules of the prosaic language. Moreover, Kafi Noonoo ideophones exhibit some syllable structures that are specific to ideophones. These are the (C1VC2C2), (CVVV…), (C1VVV…C2) and (C1VC2C2C2…). Furthermore, Kafi Noonoo is a tone language. The language has high and low tones. As the result of the study depicts ideophones of the language constitute both open and closed syllable shapes.

Yoga for incarcerated youth: Lessons from the RITS and relevance for clinical practice

The first time I taught a yoga class at the Rhode Island Training School (RITS), I opened with a body scan, both hoping to ground the students in the space and ground myself, as I wondered how they would receive this offering. There are known high rates of childhood trauma in incarcerated youth. Despite my training as a yoga teacher and teaching experiences before this residency, I was acutely aware of my inexperience teaching trauma‐sensitive yoga in this setting. I proceeded to pose a string of typical yoga instructor rhetorical questions in a calming, low tone of voice, to guide students into their physical sensations: “What body parts can you feel in contact with the earth? Where is your skin in contact with the cool surface?” when suddenly, from their supine position on the mat one of the students yelled out “My legs!” and another “My hands!” Well, this is new, I thought. And so began my own re‐training in how to teach yoga.

Synchronic Variation and Diachronic Evolution of Tone Patterns in Kunming Dialect

An acoustic experiment was conducted to analyze the tonal patterns of single characters in the Kunming dialect. The experimental results show that the Kunming dialect has a semi-high flat tone for the first tone, a low descending tone for the second tone, a high descending tone for the third tone, and a low tone for the fourth tone. The first and third tones are both high, while the second and fourth are both low tones, as opposed to the tonal patterns of "flat" and "low". The newer Kunming dialects show variation. The first tone starts and ends at a higher level, the third tone's bent section disappears, and the fourth tone starts and ends at a lower level, with a shorter tone duration. The variation in tone pattern starts in the middle-aged group in the old urban, and the degree of variation is female > male, old urban > old suburban, and the youth and middle-aged group > senior group, respectively. The female tone pattern has more similar vocal tone characteristics to those in the middle-aged and youth groups.

Correlation Between Quantitative Value of Endolymphatic Hydrops and Hearing Threshold Using Magnetic Resonance Imaging.

This study investigated the relationship between quantitative value of endolymphatic hydrops in the affected ear and the hearing threshold in patients with unilateral Meniere's disease. Prospective study. Forty patients with unilateral definite Meniere's disease were diagnosed in outpatient clinic. We recorded their clinical symptoms (duration of vertigo and tinnitus and duration of vertigo attacks), and obtained the hearing thresholds of high, middle, and low by pure tone audiometry. A 3D-FLAIR MRI revealed endolymphatic hydrops and assessed quantitative values of cochlear and vestibular endolymphatic hydrops. We assessed the correlation between hearing thresholds and quantitative values of endolymphatic hydrops. All patients showed varying degrees of endolymphatic hydrops in the affected ear. With the duration of vertigo, tinnitus and vertigo attacks as control variables, partial correlation analysis showed that the correlation coefficients between quantitative value of cochlear hydrops and hearing thresholds of low, middle, and high tone in the affected ear were 0.581, 0.610, and 0.125, respectively. The correlation coefficients between quantitative value of vestibular hydrops and hearing thresholds of low, middle, and high tone in the affected ear were 0.727, 0.569, and 0.201, respectively. The degree of endolymphatic hydrops in Meniere's disease can be revealed and assessed by 3D-FLAIR MRI after intravenous administration of double doses of gadoterate meglumine. Clinical evaluation of endolymphatic hydrops in Meniere's disease can be assisted by low- and middle-tone hearing thresholds, thereby providing anatomical support for the clinical symptoms of Meniere's disease.

Autonomic measures identify stress, pain, and instability associated with retinopathy of prematurity ophthalmologic examinations.

Retinopathy of prematurity (ROP) ophthalmologic examinations cause stress and pain. Infants' stress and pain can be measured non-invasively using skin conductance (SC) and high frequency heart rate variability (HF-HRV), reflecting sympathetic-mediated sweating and parasympathetic activity, respectively. To test the utility of SC to detect sympathetic activation during ROP examination, and the contribution of HF-HRV to predict stability post-examination. In this prospective, single center study, we measured SC continuously pre-, during, and post-examination, and HRV at 24 h pre-ROP examination. Clinical data included stability [apneas, bradycardias, and desaturations (A/B/Ds)], and interventions post-examination. SC increased 56% above baseline during ROP examination (p = 0.001) and remained elevated post-examination (p = 0.02). Post-hoc analysis showed higher illness acuity, represented by need for respiratory support, was associated with lower HF-HRV at 24 h pre-ROP examination (p = 0.001). Linear regression indicated lower HF-HRV at 24 h pre-examination contributed to the need for higher intervention (i.e., stimulation to breathe, oxygen support) particularly among infants with higher illness acuity [F(1, 15) = 5.05, p = 0.04; β = -1.33, p = 0.04]. ROP examination induced a 2-fold increase in sympathetic activation which remained above baseline in recovery. Also, we propose that the low parasympathetic tone associated with autonomic imbalance contributes to instability and need for higher intervention to assure stabilization with A/B/D events. Our findings provide insight into the underestimation of adverse events associated with ROP examination and identification of infants who may be more vulnerable to potential sequelae following ROP examinations.

Autonomic markers of extubation readiness in premature infants.

In premature infants, extubation failure is common and difficult to predict. Heart rate variability (HRV) is a marker of autonomic tone. Our aim is to test the hypothesis that autonomic impairment is associated with extubation readiness. Retrospective study of 89 infants <28 weeks. HRV metrics 24 h prior to extubation were compared for those with and without extubation success within 72 h. Receiver-operating curve analysis was conducted to determine the predictive ability of each metric, and a predictive model was created. Seventy-three percent were successfully extubated. The success group had significantly lower oxygen requirement, higher sympathetic HRV metrics, and a lower parasympathetic HRV metric. α1 (measure of autocorrelation, related to sympathetic tone) was the best predictor of success-area under the curve (AUC) of .73 (p = 0.001), and incorporated into a predictive model had an AUC of 0.81 (p < 0.0001)-sensitivity of 81% and specificity of 78%. Extubation success is associated with HRV. We show an autonomic imbalance with low sympathetic and elevated parasympathetic tone in those who failed. α1, a marker of sympathetic tone, was noted to be the best predictor of extubation success especially when incorporated into a clinical model. This article depicts autonomic markers predictive of extubation success. We depict an autonomic imbalance in those who fail extubation with heightened parasympathetic and blunted sympathetic signal. We describe a predictive model for extubation success with a sensitivity of 81% and specificity of 78%.

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis.

Depression is a worldwide disease causing severe disability, morbidity, and mortality. Despite abundant studies, the precise mechanisms underlying the pathophysiology of depression remain elusive. Recently, cumulate research suggests that a disturbance of microbiota-gut-brain axis may play a vital role in the etiology of depression while correcting this disturbance could alleviate depression symptoms. The vagus nerve, linking brain and gut through its afferent and efferent branches, is a critical route in the bidirectional communication of this axis. Directly or indirectly, the vagus afferent fibers can sense and relay gut microbiota signals to the brain and induce brain disorders including depression. Also, brain changes in response to stress may result in gut hyperpermeability and inflammation mediating by the vagal efferents, which may be detrimental to depression. Notably, vagus nerve stimulation owns an anti-inflammatory effect and was proved for depression treatment. Nevertheless, depression was accompanied by a low vagal tone, which may derive from response to stress and contribute to pathogenesis of depression. In this review, we aim to explore the role of the vagus nerve in depression from the perspective of the microbiota-gut-brain axis, highlighting the relationship among the vagal tone, the gut hyperpermeability, inflammation, and depression.

WORD-FORMING CONTAMINATION AS A MANIFESTING OF LINGUOCREATIVITY ON THE PHENOMENON OF WAR (ON THE MATERIAL OF MEDIA TEXTS)

The article considers word-forming contamination as a manifestation of the language game acquiring a pronounced pragmatic orientation to verbalize their emotional and psychological state during the military confrontation. The purpose of the study is to identify structural and semantic features of innovative contaminants in modern media discourse. The object of research is innovative derivatives in modern media texts and the subject-word-forming contaminants in the media and their structural and semantic varieties. The source base for the study served on 235 word-formation innovations recorded in the online media (mostly in telegram channels of Ukrainian and Russian opposition bloggers) from February to June 2022. It was found that the most active is the contamination type of derivatives formed by imposing one creative basis on another. In second place in terms of the number of recorded contaminants is the method of isolating one creative basis into another. It was found that 75% of the recorded graph derivatives contain the Latin letter Z, which in the Ukrainian and Russian opposition media discourse became a symbol of the Russian invasion of Ukraine and acquired a negative evaluation value. Particular attention is paid to innovations that have emerged as a result of the language game with precedent phrases from media texts of the Russian-Ukrainian war. It is proposed to nominate such occasionalism, which was formed in a lexical-syntactic way and acquired the status of hashtags, and hashtag-contaminants. It is proved that the names of the aggressor country, government officials, the military, and all supporters of imperial-militaristic policy acquire a low tone. The negative evaluation of a person or phenomenon occurs with the help of reduced-invective vocabulary, which creates an ironic color to the work. The synthetic functionality of contaminants, which perform nominative, evaluative and expressive functions at the same time, is substantiated. This fact confirms the general tendency towards the conscious desire of speakers to save word-forming means. The study provides grounds for determining the following results: modern media texts demonstrate the extraordinary activity of innovative contaminants as information weapons during the Russian-Ukrainian war; the variety of structural and semantic models of the analyzed derivatives testifies to the high creative potential of speakers and the productivity of non-casual ways of word-formation. We see the prospects of the study in the in-depth development of the structural-semantic classification of contaminants in modern media discourse.

Doświadczenia rodziców i dzieci podczas pandemii COVID-19

The study, which included a total of 1,122 Italian parents (96.5% female; 3.5% male) of children with an average age of 7.56 years (N = 1,461, SD = 2.03), explores how parents with children (5–11 years old) represent changes in their daily habits as well as their own and children’s experiences in relation to the impact caused by the health emergency. The study also investigates how work, family life, contextual factors and media exposure associated with information regarding COVID-19 have contributed to influencing emotional states and behavioural patterns. The research programme was carried out by an online questionnaire in June 2020. The pandemic was experienced in a variety of ways across four clusters. The highest levels of discomfort can be observed among those parents who have experienced isolation and the fear of contagion with higher levels of anxiety, which have been intensified by the perception of change and the deterioration in working conditions. Parents with higher emotional instability have found a low emotional stability and high depressive tones in their children. Results suggest that the capacity of parents to process and mentalise emotions by facing the difficulties and stress caused by the situation can act as a protective factor in contrasting any emotional instability in children.

Intrinsic Fundamental Frequency (IF0) and Tonal Gradient in Yorùbá

The present study investigates whether tones in tone languages constrain or control Intrinsic Fundamental Frequency (IF0), similar to the investigation conducted by Hombert (1977) and Connell (2002). Two native speakers of Yorùbá were recorded producing the seven vowels in the language with all three tones. Results of the analysis show that IF0 is found to be a gradient with respect to tones; the High tone possesses a higher F0 than the Mid tone, while the Low tone has the lowest. However, the results provide no strong evidence to support tonal gradient with respect to vowel heights. To some extent, the high vowel [u] appears to follow the prediction regarding tonal gradient, especially in comparison with the low vowel [a]; the other high vowel [i] does not. In most instances, the mid vowels record higher F0 than [i]. These mixed results are possibly due to some extralinguistic factors, such as the speakers’ habitual way of speaking, vocal tract shapes, and the larynx, among others.

Clinical manifestations and genetic analysis of a newborn with Arboleda-Tham syndrome.

Arboleda-Tham syndrome (ARTHS) is a rare disorder first characterized in 2015 and is caused by mutations in lysine (K) acetyltransferase 6A (KAT6A, a.k.a. MOZ, MYST3). Its clinical symptoms have rarely been reported in newborns from birth up to the first few months after birth. In this study, a newborn was diagnosed with ARTHS based on the clinical symptoms and a mutation c.3937G>A (p.Asp1313Asn) in KAT6A. The clinical manifestations, diagnosis, and treatment of the newborn with ARTHS were recorded during follow-up observations. The main symptoms of the proband at birth were asphyxia, involuntary breathing, low muscle tone, early feeding, movement difficulties, weak crying, weakened muscle tone of the limbs, and embrace reflex, and facial features were not obvious at birth. There was obvious developmental delay, as well as hypotonic and oro-intestinal problems in the first few months after birth. Mouse growth factor was used to nourish the brain nerves, and touching, kneading the back, passive movements of the limbs, and audio-visual stimulation were used for rehabilitation. We hope that this study expands the phenotypic spectrum of this syndrome to newborns and the library of KAT6A mutations that lead to ARTHS. Consequently, the data can be used as a basis for genetic counseling and in clinical and prenatal diagnosis for ARTHS prevention.