The low temperature transport and magnetic properties were investigated in the misfit-layered Ca 2 Co 2 O 5 compound. The compound exhibits incommensurate spin-density-wave (SDW) state in the dχ-1/dT curve at 20 K, which is confirmed by the resistivity (ρ) characterization. The resistivity shows an upturn from metallic to insulating behavior at TM-I (130 K) and strong Fermi liquid behaviors with ρ ~ T2 relation between TM-I and T*(225 K ). The Seebeck coefficient shows abnormal temperature dependence at Tp (40 K), which is suggested to origin from the long order of atomic in [ Ca 2 CoO 3] sublayer and spin fluctuation of Co ions. Moreover, large Seebeck coefficient (120 μV/K) and low thermal conductivity (2.5 W/mK) were obtained at room temperature, indicating that it is a promising p-type thermoelectric material for energy conversion.