Low Stiffness Research Articles

The Association Between Cardiovagal Baroreceptor Sensitivity and Hippocampal Tissue Integrity in Young and Middle-aged Adults

Prior research has investigated the association of cardiovagal baroreceptor sensitivity (BRS) with white matter neuronal integrity and cerebral perfusion using magnetic resonance imaging (MRI) techniques such as diffusion tensor imaging (DTI) and arterial spin labeling (ASL); however, less is known about the association with specific regions of gray matter (i.e, hippocampus) involved in memory formation and recall. MR elastography (MRE) has emerged as a constructive tool for assessing the viscoelastic mechanical properties of the brain which are believed to reflect the microstructural integrity of neuronal tissue. PURPOSE: To investigate the association between cardiovagal BRS and the viscoelastic properties of the brain, with a sub goal of examining how advanced age affects this association. We hypothesized that there would be a positive relation between cardiovagal BRS and hippocampal (HC) viscoelastic properties that strengthens with age, indicating a greater influence of blood pressure control on HC microstructural integrity. Methods: Ten young (Yng, 25 ± 2 years) and ten middle-aged adults (MA, 55 ± 3 years) laid in supine position for 10 minutes while arterial blood pressure (ABP) and heart rate (HR) were measured. R-R intervals and systolic blood pressures were plotted within a linear regression to calculate the spontaneous baroreflex slope. Subjects went in an MRI scanner to measure hippocampal viscoelastic properties using MRE. Results: As expected, we observed a lower cBRS in the middle-aged group compared with young (MA: 12.51±4.41 vs. Yng: 25.21±8.77 ms/mmHg, p≤0.05). There were no significant differences in HC stiffness or damping ratio when comparing between age groups (MA: 3.06±0.32 kPa vs. Yng: 3.02±0.09 kPa, p=0.69; MA: 0.2±0.02 vs. Yng: 0.2±0.03, p=0.56). However, a multiple linear regression with age included as a categorical covariate revealed a trend towards a stronger association between HC stiffness and cBRS in the middle-aged compared to the young group (p=0.07). CONCLUSION: In contrast to our hypothesis, preserved BRS was associated with lower HC stiffness in the middle-aged group; however, the physiological importance of this finding needs to be more completely explored. Our findings indicate that the association between short-term blood pressure regulation via cardiovagal BRS may be more closely linked to HC tissue integrity with advancing age. These mechanisms should be explored in a larger cohort including older individuals. Supported by UD Research Foundation 2020 Pilot Grant and P20GM113125. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Latarjet procedure: biomechanical evaluation of 2-screw coracoid fixation

Coracoid nonunion is a relevant complication following the Latarjet procedure and is influenced by multiple factors, including the method of graft fixation. The purpose of this study was to evaluate and characterize the biomechanical properties of various two-screw fixation constructs used for coracoid graft fixation in the Latarjet procedure. Forty model scapulae (Sawbones Inc., Vashon, WA, USA) were used for this study. A 15% anterior inferior glenoid bone defect was created. The coracoid was osteotomized at the juncture of the vertical and horizontal aspects, transferred to the anterior-inferior edge of the glenoid, and fixed with either two 3.5mm fully threaded cannulated cortical screws, two 3.5mm fully threaded solid cortical screws, two 3.5mm partially threaded cannulated screws, or two 4.5mm partially threaded malleolar screws (MS). Biomechanical testing was performed with an Instron material testing machine (Instron Corp., Norwood, MA, USA) by applying loads to the lateral aspect of the transferred coracoid graft. The constructs were preconditioned with nondestructive cyclical loading (0N-20N) to determine construct stiffness. After 100 cycles of dynamic loading, the construct was loaded to failure to determine ultimate failure load, yield displacement, and mode of failure. All failures were associated with plastic deformation of the screws and coracoid graft fracture. There was a significantly lower initial stiffness for partially threaded cannulated screws compared to MS (186±49.3N/mm vs. 280±65.5N/mm, P=.01) but no significant differences among the other constructs. There was no difference in ultimate failure load (P=.18) or yield displacement (P=.05) among constructs. Two screw coracoid fixation of the coracoid in a simulated classic Latarjet procedure with 3.5mm fully threaded cortical and cannulated screws is comparable to 4.5mm MS in strength, stiffness, and displacement at failure. On the other hand, partially threaded 3.5mm cannulated screws provide inferior fixation stiffness and could potentially affect clinical outcomes.

Optimization method for clamping layout of refractory thin-wall parts based on IAGA-Elman

Thin-walled parts made of refractory materials are widely used in the sintering field of lithium battery powder materials. To solve the problem of deformation and fracture caused by the low stiffness of refractory thin-wall parts, a sandwich-layout proxy optimization model based on the IAGA-Elman neural network and sub-optimization mechanism was proposed. Based on ABAQUS, finite element simulation models under different clamping layouts were obtained. The sample set required for neural network training was established, a sub-optimization mechanism with MSP+EI combination plus point criterion as the target task was constructed, and the IAGA algorithm was used to optimize the Elman neural network for optimal parameter seeking. The deep nonlinear mapping relationship between clamping layout parameters and clamping deformation is explored by proxy optimization model. The experimental results show that the proposed method can predict the clamping deformation of thin-walled parts with fewer simulations and higher fitting accuracy, and can provide a basis for the optimal design of the clamping layout of refractory thin-walled parts.

Design optimization of integral stiffeners for 3D woven composite preforms

Although 3D orthogonal textile woven composite panels demonstrate good impact damage resistance, they often have relatively low bending stiffness. Typically, stiffeners are added to improve the bending resistance through fabrication processes such as sewing and panel/flange joining through matrix adhesion. These secondary processes can be undesirable, adding expense and potential weak points to the structure. Inspired by bio-structures such as peanut shells with surface ridges and graded through-thickness densities, we seek to develop embedded stiffeners for 3D orthogonal textile woven composite panels at sub-component scale to enhance the bending stiffness. Such stiffened textile architecture can be integrally fabricated in an orthogonal loom using standard weaving methods and provides a balance between improving structural bending stiffness and the manufacturing cost and maintaining good impact damage resistance. Utilizing a manufacturing-based parameterization method, a low-fidelity evaluation tool based on the iso-strain method is developed and a straightforward design methodology is proposed to implement these novel composite structures. Numerical design optimization examples are demonstrated.

Design and Testing of a Compliant ZTTΘ Positional Adjustment System with Hybrid Amplification.

This article presents the design, analysis, and prototype testing of a four-degrees-of-freedom (4-DoFs) spatial pose adjustment system (SPAS) that achieves high-precision positioning with 4-DoFs (Z/Tip/Tilt/Θ). The system employs a piezoelectric-driven amplification mechanism that combines a bridge lever hybrid amplification mechanism, a double four-bar guide mechanism, and a multi-level lever symmetric rotation mechanism. By integrating these mechanisms, the system achieves low coupling, high stiffness, and wide stroke range. Analytical modeling and finite element analysis are employed to optimize geometric parameters. A prototype is fabricated, and its performance is verified through testing. The results indicate that the Z-direction feed microstroke is 327.37 μm, the yaw motion angle around the X and Y axes is 3.462 mrad, and the rotation motion angle around the Z axis is 12.684 mrad. The x-axis and y-axis motion magnification ratio can reach 7.43. Closed-loop decoupling control experiments for multiple-input-multiple-outputs (MIMO) systems using inverse kinematics and proportional-integral-derivative feedback controllers were conducted. The results show that the Z-direction positioning accuracy is ±100 nm, the X and Y axis yaw motion accuracy is ±2 μrad, and the Z-axis rotation accuracy is ±25 μrad. Due to the ZTTΘ mechanism, the design proved to be feasible and advantageous, demonstrating its potential for precision machining and micro-nano manipulation.

High throughput clogging free microfluidic particle filter by femtosecond laser micromachining.

In recent decades, driven by the needs of industry and medicine, researchers have been investigating how to remove carefully from the main flow microscopic particles or clusters of them. Among all the approaches proposed, crossflow filtration is one of the most attractive as it provides a non-destructive, label-free and in-flow sorting method. In general, the separation performance shows capture and separation efficiencies ranging from 70% up to 100%. However, the maximum flow rate achievable (µL/min) is still orders of magnitude away from those suitable for clinical or industrial applications mainly due to the low stiffness of the materials typically used. In this work, we propose an innovative hydrodynamic-crossflow hybrid filter geometry, buried in a fused silica substrate by means of the femtosecond laser irradiation followed by chemical etching technique. The material high stiffness combined with the accuracy of our manufacturing technique allows the 3D fabrication of non-deformable channels with higher aspect ratio posts, while keeping the overall device dimensions compact. The filter performance has been validated through experiments with both Newtonian (water-based solution of microbeads) and non-Newtonian fluids (blood), achieving separation efficiencies of up to 94% and large particles recovery rates of 100%, even at very high flow rates (mL/h).

Silica-coated liquid metal nanoparticles with different stiffness for cellular uptake-enhanced tumor photothermal therapy

Cells can sense the mechanical stimulation of nanoparticles (NPs) and then regulate the cellular uptake process. The enhanced endocytosis efficiency can improve the concentration of NPs in tumor cells significantly, which is the key prerequisite for achieving efficient biological performance. However, the preparation methods of NPs with flexible and tunable stiffness are relatively limited, and the impact of stiffness property on their interaction with tumor cells remains unclear. In this study, soft liquid metal (LM) core was coated with hard silica layer, the obtained core-shell NPs with a wide range of Young's modulus (130.5 ± 25.6 MPa - 1729.2 ± 146.7 MPa) were prepared by adjusting the amount of silica. It was found that the NPs with higher stiffness exhibited superior cellular uptake efficiency and lysosomal escape ability compared to the NPs with lower stiffness. The silica layer not only affected the stiffness, but also improved the photothermal stability of the LM NPs. Both in vitro and in vivo results demonstrated that the NPs with higher stiffness displayed significantly enhanced tumor hyperthermia capability. This work may provide a paradigm for the preparation of NPs with varying stiffness and offer insights into the role of the mechanical property of NPs in their delivery.

Soft gliadin nanoparticles at air/water interfaces: The transition from a particle-laden layer to a thick protein film

HypothesisProtein-based soft particles possess a unique interfacial deformation behavior, which is difficult to capture and characterize. This complicates the analysis of their interfacial properties. Here, we aim to establish how the particle deformation affects their interfacial structural and mechanical properties. ExperimentsGliadin nanoparticles (GNPs) were selected as a model particle. We studied their adsorption behavior, the time-evolution of their morphology, and rheological behavior at the air/water interface by combining dilatational rheology and microstructure imaging. The rheology results were analyzed using Lissajous plots and quantified using the recently developed general stress decomposition (GSD) method. FindingThree distinct stages were revealed in the adsorption and rearrangement process. First, spherical GNPs (∼105 nm) adsorbed to the interface. Then, these gradually deformed along the interface direction to a flattened shape, and formed a firm viscoelastic 2D solid film. Finally, further stretching and merging of GNPs at the interface resulted in rearrangement of their internal structure to form a thick film with lower stiffness than the initial film. These results demonstrate that the structure of GNPs confined at the interface is controlled by their deformability, and the latter can be used to tune the properties of prolamin particle-based multiphase systems.

Seismic behavior of precast segmental bridge columns confined by grouted glass fiber reinforced plastic tubes

The application of precast segmental bridge columns (PSBCs) is still restricted in seismicity areas due to concerns such as lower lateral stiffness and column base bearing capacity. To enhance the applicability of PSBCs, this study proposed a novel approach of confining them with grouted GFRP tubes. Four novel and one reference specimens were tested under low cyclic loading to evaluate the effects of energy dissipation (ED) bars ratios, concrete interlayer strength, type of segment concrete, and concrete pouring methods within the outer GFRP tube (OGT) on the seismic behavior. Experimental results reveal that the failure modes of all specimens were triggered by the yielding of ED bars and the break of OGT at the top of ED bars. No crushed concrete at column bases or cracks at the segment joint were observed during the test due to the good confinement of GFRP tubes. All the specimens exhibited stable hysteretic behavior with small residual drift ratios and low strength degradation. Furthermore, finite element models (FEMs) were generated to predict the hysteretic behavior of novel specimens. The effects of some parameters such as OGT thickness, ED bars diameter, and concrete strength were further studied.

Static and modal analysis of sandwich panels with rib-reinforced re-entrant honeycomb

The low stiffness resulting from substantial core porosity within the re-entrant honeycomb sandwich panel can be addressed by introducing rib-reinforcements. To investigate its static and vibration characteristics, an energy-based 2D equivalent-homogenization model (2D-EHM) was derived through asymptotic analysis of the leading terms in the governing equations considering the energy-related characteristics. The accuracy of the constructed model for predicting the elastic bending performance of the sandwich panel was verified by comparing the results of a three-point bending experiment with 3D-printed specimens. Comparative analysis with a 3D FE model demonstrates that the 2D-EHM exhibits maximum errors of only 4.65% and 6.46%, respectively, in analyzing static deformation and natural frequency while improving computational efficiencies by up to 59- and 173-folds. Parameter analysis reveals that the performance of SP-RRH is minimally affected by the reinforcement-to-honeycomb wall thickness ratio. However, its performance is compromised when the honeycomb walls align in an equilateral triangle with the reinforcing walls. Comparing specific stiffness as well as static and vibration characteristics of sandwich panels with different core configurations (including traditional and diamond reinforced re-entrant honeycombs) shows that inclusion of rib reinforcements enhances deformation resistance and natural frequencies through increased specific stiffness. These findings provide valuable insights for optimizing design of re-entrant honeycomb sandwich panels.

Wide quasi-zero stiffness region isolator with decoupled high static and low dynamic stiffness

Quasi-zero stiffness (QZS) isolators can achieve the two goals of relatively high static and low dynamic stiffness (HSLDS). However, the static and dynamic stiffness of most QZS isolators remains coupled, causing conflicts in optimizing these dual objectives, especially in the case of large displacement excitations and heavy loads, leading to limited performance. To overcome these limitations, this paper presents an isolator with an extended QZS region that allows for the independent design of HSLDS. The positive stiffness provided by the cantilever beam with curve fixture (CBCF) precisely counteracts the negative stiffness offered by a pair of inclined springs, thereby achieving continuous and extensive QZS characteristics from a point to a region. Dynamic equations are established based on the Lagrangian principle and swiftly solved utilizing the Runge-Kutta-4 method. The proposed isolator exhibits a low resonance frequency, and superior performance when exposed to large displacement excitations compared to alternative isolators. Both static and dynamic experiments confirm a QZS region of 0.023 m and resonance frequencies of below 1 Hz. The proposed isolator facilitates effective vibration isolation for ultra-low-frequency and large displacement excitations.

The neck structure design of vehicle crash finite element dummy model

Anthropomorphic Test Devices (ATDs) with high biofidelity and compatibility play a crucial role in vehicle safety. This study focuses on enhancing the neck of Hybrid III finite element model by optimising its design and material. The improved Hybrid III model (IH3) is validated through neck calibration tests. Comparing to experimental results,IH3 has a peak torque error of only 1.00% and 5.11%and a 60.04% improvement in calculation efficiency. Then MLH3 with low stiffness and equivalent muscles and ligaments is designed and tested. The results of MLH3 show higher biofidelity than l than Hybrid III. Finally, both IH3 and MLH3 have been tested in a 100% frontal rigid barrier test, with IH3 showing significant accuracy and computational efficiency, indicating that it could replace the current Hybrid III neck for simulation analysis. MLH3 has potential engineering application value in the future, as it improves upon the limitations of the Hybrid III neck’s biofidelity and more closely resembles the real human neck.

Gas-Spring Quasi-Zero Stiffness Air Damping Isolator for Vertical Vibration Control of Indoor Substation Excited by Metro Loads

To mitigate the metro-induced vertical vibration of the indoor substation structure, this study proposes a gas-spring quasi-zero stiffness air damping isolator (AD-QZSI) with excellent low dynamic stiffness and high-static stiffness characteristics. The working principle and mechanical properties of the AD-QZSI are introduced and studied through theoretical and numerical methods. A model for substation considering soil–structure–equipment interaction is established using the software ABAQUS, its accuracy is validated based on a series of measured data from actual projects, and the AD-QZSI’s simulation method and parameter design method are described in detail. The air damper’s stiffness [Formula: see text] is integrated into the isolator’s mechanical model, theoretically and numerically achieving an accurate simulation of AD-QZSI’s nonlinear mechanical properties. The numerical results have an error of less than 5% with the measured data, indicating that the model is able to better capture the actual structure’s dynamic characteristics and is reasonable to be employed for subsequent analysis. Numerical results show that AD-QZSI can significantly reduce the structural vertical vibration, and its control effect is better in the whole frequency band, in particular, the effect is also visible in the low-frequency band, indicating that its vibration isolation frequency band is wider than that of traditional QZS isolator. With the vibration source distance increasing, the control effect of AD-QZSI presents a tendency to decrease and then level off, and its vibration isolation gain is weakened by the continuous increase of the damping ratio greater than 0.01. Moreover, the equipment’s dynamic amplification factor of the isolated structure decreases significantly. Finally, the proposed AD-QZSI can obtain ideal quasi-zero stiffness characteristics by adjusting the air pressure, and the adopted air damper belongs to the green low-carbon components, featuring great practical value and application prospects.

Controlled Stiffness of Direct-Write, Near-Field Electrospun Gelatin Fibers Generates Differences in Tenocyte Morphology and Gene Expression.

Tendinopathy is a leading cause of mobility issues. Currently, the cell-matrix interactions involved in the development of tendinopathy are not fully understood. In vitro tendon models provide a unique tool for addressing this knowledge gap as they permit fine control over biochemical, micromechanical, and structural aspects of the local environment to explore cell-matrix interactions. In this study, direct-write, near-field electrospinning of gelatin solution was implemented to fabricate micron-scale fibrous scaffolds that mimic native collagen fiber size and orientation. The stiffness of these fibrous scaffolds was found to be controllable between 1 MPa and 8 MPa using different crosslinking methods (EDC, DHT, DHT+EDC) or through altering the duration of crosslinking with EDC (1 h to 24 h). EDC crosslinking provided the greatest fiber stability, surviving up to 3 weeks in vitro. Differences in stiffness resulted in phenotypic changes for equine tenocytes with low stiffness fibers (∼1 MPa) promoting an elongated nuclear aspect ratio while those on high stiffness fibers (∼8 MPa) were rounded. High stiffness fibers resulted in the upregulation of matrix metalloproteinase (MMPs) and proteoglycans (possible indicators for tendinopathy) relative to low stiffness fibers. These results demonstrate the feasibility of direct-written gelatin scaffolds as tendon in vitro models and provide evidence that matrix mechanical properties may be crucial factors in cell-matrix interactions during tendinopathy formation.

Synergizing Structural Stiffness Regulation with Compliance Contact Stiffness: Bioinspired Soft Stimuli‐Responsive Materials Design for Soft Machines

Stiffness regulation strategies endow soft machines with stronger functionality to cope with diverse application requirements, for example manipulating heavy items by improving structural stiffness. However, most programmable stiffness strategies usually struggle to preserve the inherent compliant interaction capabilities following an enhancement in structural stiffness. In this study, inspired by the musculocutaneous system, we propose a soft stimuli‐responsive material (SRM) by combining shape memory alloy into compliant materials. By characterizing the mechanical performance, the flexural modulus increases from 6.6 to 142.4 MPa under the action of active stimuli, crossing two orders of magnitude, while Young's modulus stays at 2.2 MPa during programming structural stiffness. This comparative result indicates that our SRMs can keep a lower contact stiffness for compliant interaction although structural stiffness increases. Then, we develop three diverse soft machines to show the application potential of this smart material, such as robotic grippers, wearable devices, and deployable mechanisms. By applying our materials, these machines possess stronger load‐bearing capabilities. Meanwhile, these demonstrations also illustrate the efficacy of this paradigm in regulating the structural stiffness of soft machines while maintaining their compliant interaction capabilities.

Comprehensive effects of aerodynamic performance and dynamic strength of aircraft wings after bird strike in numerical simulation

ABSTRCT To enhance the bird strike resistance of fixed-wing aircraft wings, a combined computational approach integrating nonlinear solid mechanics and fluid dynamics was employed to analyze the bird strike characteristics of both traditional aluminum alloy skins and novel composite materials skins. Additionally, a standardized procedure was established to simulate aircraft structural damage more comprehensively, swiftly, and accurately during bird strikes, along with diagnostic analysis of flow field changes near the wing post-impact. This method not only quantifies wing strength damage but also establishes corresponding relationships between damage severity and aerodynamic performance degradation. The research findings indicate that the deformation of composite material skin wings is only a quarter of that of aluminum alloy skin wings. Composite material skins absorb less harmful energy compared to aluminum alloy skins, with consistently lower stiffness reduction rates at various bird strike velocities. Velocity distribution on deformed wings with composite material skins exhibits minimal deviation compared to normal wings, thereby preventing airflow separation. The research results provide more comprehensive guidance for the selection of materials for bird strike resistance of aircraft wings and the airworthiness evaluation after bird strikes. Highlights This paper establishes a standardized procedure that enables a more comprehensive, faster, and higher-precision simulation of structural damage to the aircraft during a bird strike on the wing and allows for the diagnostic analysis of the flow field changes near the wing after bird strike. By coupling nonlinear solid mechanics and fluid dynamics computational methods, the aerodynamic performance of the wings at different angles of attack post-deformation is investigated. This approach not only quantifies the strength damage to the wings but also establishes corresponding relationships between the degree of damage and the deterioration in aerodynamic performance. The research yields insights into the aerodynamic performance degradation patterns with varying angles of attack for both composite material skin and aluminum alloy skin deformed wings. These findings can serve as valuable references for pilots in emergency situations, aiding in their decision-making regarding aircraft control.

High-precision modelling of deformation of sandwich structures under bilateral symmetric and oblique-symmetric loading

The analysis and assessment of the stress-strain state (STS) of multilayer plates with orthotropic layers under the action of stationary transverse and tangential loads is an urgent task. It includes calculations on the strength and deformability of various homogeneous and multi-layered plates with layers of constant thickness but arbitrary structure according to the thickness of the plate. Combining materials with isotropic and transversely isotropic physical characteristics into a multilayer package allows you to create multifunctional structures. The SSS of such structures, due to their structural heterogeneity and relatively low transverse stiffness of the individual layers, is significantly associated with the influence of transverse shear deformations and transverse compression deformations. Therefore, the problem of refined modeling of SSS plates, which would take into account these types of deformations, is urgent. Based on the decomposition of the SSS plate into flexural and unflexural components, it is proposed to optimize the design scheme of deformation of a rectangular multilayer plate. This significantly simplifies its modeling. For unflexural and exclusively flexural SSS, a two-dimensional, high-degree iterative approximation, but three-dimensional models of deformation of multilayer rectangular plate on a rigid foundation with isotropic, transverse-isotropic and orthotropic layers are constructed in an elastic formulation. That models takes full account deformation of transverse shear and transverse compression at transverse and the tangential loading of a plate. The model is continuous, that is, the number of equations and the order of differentiation of the calculation system of equations does not depend on the number of layers in the slab. This order of differentiation and the number of calculation equations can depend only on the order of iterative approximation of the model. A way of precise satisfaction of all defining correlations of the layers of material under keeping the conditions of their contact is found, while in the known continual models the dependence between the cross normal stress and cross deformation is only integral.The results of the analytical solution of the problem of deformation of a rectangular plate under boundary conditions of the Navier type under the action of transverse and tangential loads are given. By solving the test problems of the deformation of two-layer plates with transversally isotropic layers and three-layer plates with orthotropic layers and comparing the solutions with the exact three-dimensional solutions of these problems obtained by known methods, an assessment of the accuracy of the proposed refined models is given. The limits of admissible parameters of elastic characteristics of transversely isotropic and orthotropic plates for application of the offered models are established.

The role of the extracellular matrix in the reduction of lateral force transmission in muscle bundles: A finite element analysis

Background and objectiveAging is associated with a reduction in muscle performance, but muscle weakness is characterized by a much greater loss of force loss compared to mass loss. The aim of this work is to assess the contribution of the extracellular matrix (ECM) to the lateral transmission of force in humans and the loss of transmitted force due to age-related modifications. MethodsFinite element models of muscle bundles are developed for young and elderly human subjects, by considering a few fibers connected through an ECM layer. Bundles of young and elderly subjects are assumed to differ in terms of ECM thickness, as observed experimentally. A three-element-based Hill model is adopted to describe the active behavior of muscle fibers, while the ECM is modeled assuming an isotropic hyperelastic neo-Hookean constitutive formulation. Numerical analyses are carried out by mimicking, at the scale of a bundle, two experimental protocols from the literature. ResultsWhen comparing numerical results obtained for bundles of young and elderly subjects, a greater reduction in the total transmitted force is observed in the latter. The loss of transmitted force is 22 % for the elderly subjects, while it is limited to 7.5 % for the young subjects. The result for the elderly subjects is in line with literature studies on animal models, showing a reduction in the range of 20–34 %. This can be explained by an alteration in the mechanism of lateral force transmission due to the lower shear stiffness of the ECM in elderly subjects, related to its higher thickness. ConclusionsComputational modeling allows to evaluate at the bundle level how the age-related increase of the ECM amount between fibers affects the lateral transmission of force. The results suggest that the observed increase in ECM thickness in aging alone can explain the reduction of the total transmitted force, due to the impaired lateral transmission of force of each fiber.

Incidence and risk factors for shoulder stiffness after open and arthroscopic rotator cuff repair.

The aim of this study was to estimate the incidence of stiffness during the first 6 months after rotator cuff repair and to evaluate postoperative stiffness with respect to its risk factors and its influence on the outcome at 6 months postoperatively. In a prospective cohort of 117 patients (69 women, 48 men; average age 59) from our institutional rotator cuff registry, who underwent either arthroscopic (n = 77) or open (n = 40) rotator cuff repair, we measured shoulder range of motion (ROM) at 3 and 6 months post-surgery. We evaluated the incidence of stiffness and analyzed functional outcomes, comparing various preoperative and intraoperative factors in patients with stiffness to those without at the 6-month mark. Shoulder stiffness was observed in 31% of patients (36/117) at 3 months postoperatively, decreasing to 20% (23/117) at 6 months. No significant link was found between stiffness at 6 months and demographic factors, preoperative stiffness, tear characteristics, or the type of repair. Notably, patients undergoing arthroscopic repair exhibited a 4.3-fold higher risk (OR 4.3; 95% CI 1.2-15.6, p = 0.02) of developing stiffness at 6 months compared to those with mini-open repair. Despite these differences in stiffness rates, no significant variation was seen in the American Shoulder and Elbow Surgeons (ASES) score, Single Assessment Numeric Evaluation (SANE) score, or Visual Analog Scale (VAS) scores at 6 months between the groups. The incidence of postoperative shoulder stiffness following rotator cuff repair was substantial at 31% at 3 months, reducing to 20% by 6 months. Mini-open repair was associated with a lower 6-month stiffness incidence than arthroscopic repair, likely due to variations in rehabilitation protocols. However, the presence of stiffness at 6 months post-surgery did not significantly affect functional outcomes or pain levels.

Combination of a Viscoelastic and a Tribological Analysis of a Low‐Density Polyethylene with a High Degree of Cross‐linking

AbstractCross‐linking of polymers is an efficient method to tailor the end‐use properties of polymer materials. Cross‐linking using a chemical agent, e.g., dicumyl peroxide (DCP), allows for a spatially uniform network formation in the melt state. In addition, it is also associated with side reactions which influence the final properties of the plastic part. This work investigates the influence of DCP concentration on the tribological properties of a cross‐linked low‐density polyethylene (LDPE) grade. In particular, high DCP concentrations up to 20 phr are chosen in order to explore the effect of a high degree of cross‐linking. The viscoelastic properties below and above the melting temperature are studied in detail to support the interpretation of the tribological results. Rheological investigations allow one to monitor the cross‐linking of the long‐chain branched LDPE. The data and the subsequent optical analysis show that wear already is significantly reduced at a low DCP concentration of 1 phr because of the covalent bonds caused by cross‐linking. A high DCP concentration of 20 phr yields an increase of coefficient of friction which can be explained by the low stiffness and the resulting high contact area in the case of highly cross‐linked LDPE.