Cross-Sector Partnerships to Deliver Health Equity Wengora E. Thompson, DrPH, MPH (bio), Kelly Jean Thomas Craig, PhD (bio), Kyu B. Rhee, MD, MPP (bio), Sreekanth K. Chaguturu, Md (bio), and Joneigh S. Khaldun, Md, Mph, Facep (bio) The coronavirus disease 2019 (COVID-19) pandemic has been an awakening to the entire globe and has unveiled to the public long-standing and unaddressed social inequities in the United States (U.S.). Over one million people in the U.S. have lost their lives to this terrible disease,1 and the long-term health, economic, and psychological impacts—while still undefined in detail—are significant,2 and for many remain unaddressed. The impacts of the pandemic have been much greater among those who are historically marginalized;3 these groups include people of color, LGBTQIA+ populations, those living with a disability, immigrants, people living in rural areas, the elderly, and those with lower socioeconomic status (education, income, and occupation) including the uninsured/underinsured. In 2021, over 30 million people in the U.S. suffered from food insecurity,4 which can be a temporary or long-term condition; lack of consistent access to affordable nutritious food leaves many households hungry. Furthermore, in 2021 15% of all renters were behind on their rent payments resulting in housing insecurity and many evictions.5 These preventable conditions are inequitably distributed, falling more heavily on racial/ethnic minority groups and low socioeconomic status groups across many health conditions. For example, concerning U.S. rates of maternal morbidity and mortality, women of color face risks of pregnancy-related complications and death that are more than double those of White women.6 In other examples of health disparities, the burden of death and illness associated with chronic diseases (such as diabetes,7 hypertension,8 cardiovascular disease,8 cancer,9 sickle cell disease,10 and human immunodeficiency virus11) experienced by people of color is markedly heavier than that of White populations. Non-Hispanic Black people are twice as likely as non-Hispanic White people to die from diabetes.7 Furthermore, when compared with White people, Black people have hypertension that [End Page 1] is earlier-onset, harder to control, and associated with worse outcomes;12 the Black population has five times as many potentially preventable hospitalizations and more end-organ damage; half of the cardiovascular mortality disparity between Black and White populations is attributed to hypertension.8 These health disparities reflect harsh, longstanding inequities—often stemming from structural racism—in education, employment, housing, and health care that were exacerbated by the pandemic.2 The reasons for these inequities, and thus the solutions to address them, are complex and require input from and collaboration among multiple stakeholders, as well as genuine and sustained input and partnership with communities. Many organizations, both private (e.g., health care, technology, and private nonprofits) and public (government), are extending their reach by establishing cross-sector partnerships to initiate actions that promote health and wellness in communities, workplaces, schools, and other settings in addition to addressing social determinants of health (SDoH) for all community members. Recognizing the contributions of social and physical environment to health (i.e., SDoH) and cooperatively addressing needs—such as housing, food, safety, and transportation—have the potential to deliver a scaled and community-specific impact. Public-private partnerships can identify both the social and health needs of community members and offer the promise of improving health outcomes and reducing health care costs with tailored interventions, assistance programs, and other personalized resources. The focus of this supplemental issue is the potential of public-private partnerships to advance health equity and address unmet needs. CVS Health® has a longstanding history of identifying and addressing health disparities and inequities and using partnerships to integrate care and services based on comparable missions and complementary capacities. When Aetna®, acquired by CVS Health in 2018,13 became the first national health plan to collect race and ethnicity data in 2003,14 it was a progressive and unmatched step towards improving population health on behalf of payers. The acquisition of these standardized demographic data is key to identifying disparities in quality of care and targeting quality interventions to achieve equity. Further, the curation of an equity-centric...