The response of Fibre metal laminates (FMLs) to low-speed impact, including displacement at impact center, stress, strain response, and metal and fiber damage during the process was studied. Three types of stainless steel based FMLs with carbon fibre reinforced plastic (CFRP) specimens with different interface connections were designed and low-speed impact tests were carried out on these specimens. At the same time, finite element software ABAQUs is also used to simulate the impact process. During this process, we employ a cohesive element to characterize the bonding relationship of the interface, moreover, the influence of interface connection strength on impact resistance performance of FMLS is emphatically studied. The results show that the mechanical response and damage state of FMLS under different interface connection modes are greatly different, and the higher the connection strength, the better the overall impact resistance of the specimen. When the connection strength is poor, the specimen is easy to be separated when subjected to impact, and the metal layer suffers early damage failure, which is not ideal for the whole structure.