Crop N needs are not usually predicted based on cropping intensity or on tillage practice. However, N fertilizer requirements may increase dramatically as less fallow and less tillage are used in semi-arid regions of the Great Plains where summer fallow cropping is common. This long-term experiment was conducted to study the influence of N fertilizer rate, source/placement/timing (NSP), and crop rotation factors on the production of winter wheat (Triticum aestivum L.), corn (Zea mays L.), and grain sorghum (Sorghum bicolor L.), as well as their fertilizer N use efficiency (FNUE) for the initial years of conversion to no-till dryland farming. Research was conducted from 1987 through 1992 on two soils (Keith clay loam, a fine-silty, mixed, mesic Aridic Argiustoll and Weld loam, a fine-silty, mixed, mesic, Aridic Argiustoll) in eastern Colorado. Rotations included winter wheat-fallow (WF) and winter wheat-corn or grain sorghum-fallow (WCF). Wheat yields were similar between WF and WCF with adequate N application. Response to N fertilizer at lower rates was greater in WCF than WF because of its greater depletion of soil N. Corn production averaged 72 bu/acre with adequate N and required 1 Ib/acre of N uptake to produce 1 bu/acre of grain. Current N fertilizer recommendations for wheat and corn were not adequate to insure maximum production under no-till management. Fertilizer placement significantly affected average annual rotational yield (40 to 70 Ib/acre per yr difference) but application rate was more important economically. Grain biomass produced in each rotation per pound of total plant N uptake (GNUE) was 17 Ib/acre per yr in WF compared with 29 Ib/acre per yr for WCF. This 70% increase in average annual grain production of WCF over WF was accomplished with a 44% annual increase in fertilizer N application.