Dermal exposures to environmental chemicals can significantly affect the morphology and integrity of skin structure, leading to enhanced and deeper penetration of toxic chemicals. This problem can be magnified during disasters where hazardous water-soluble chemicals are readily mobilized and redistributed in the environment, threatening the health of vulnerable populations at the impacted sites. To address this issue, barrier emulsion formulations (EVB) have been developed consisting of materials that are generally recognized as safe, with the inclusion of medical grade carbon or calcium and sodium montmorillonite clays (CM and SM). In this study, the adsorption efficacy of five highly toxic and commonly occurring contaminants of concern, including important hydrophilic pesticides (glyphosate, acrolein, and paraquat) and per- and polyfluoroalkyl substances were characterized. EVB showed properties such as high stability, spreadability, low rupture strength, and neutral pH that were suitable for topical application on the skin. The in vitro adsorption results indicated that EVB and EVB-SM were effective, economically feasible, and favorable barrier formulations for hazardous chemical adsorption, as supported by high binding percentage, low desorption rates for an extended period of time, and high binding affinity. A pseudo-second-order kinetic model was best fitted for the adsorption process and the Freundlich model fit the adsorption isotherms with negative enthalpy values indicating spontaneous reactions that involve physisorption. The study, with varying temperatures and pH, showed that the adsorption reaction was exothermic and persistent. The results indicated that EVB and EVB-SM can be used as effective barriers to block dermal contact from water-soluble toxic pollutants during disasters.