With the recent approval of target-specific anticoagulants (TSAs) for outpatient treatment of pulmonary embolism (PE), low-risk patients may now be discharged home from the emergency department (ED) after diagnosis. We have established an outpatient clinic ensuring consistent follow-up of patients with low-risk PE by Hestia criteria, with an institutional protocol facilitating safe and immediate discharge of these patients from the ED. Survey the attitudes and opinions of academic practitioners about their willingness to discharge low-risk PE patients after implementation of a structured protocol and guaranteed clinic follow-up. One year after implementing the home treatment protocol, (N=111 ED patients with thrombosis), we created a structured online questionnaire consisting of eleven questions. This survey was sent to all attending and resident physicians practicing at two facilities that used the protocol and referred to clinic. Self-reported comfort with discharge was determined by visual analog slider and analyzed by paired t-test pre- and post-clinic. Correlation was determined with Pearson r. Both structured and open-ended questions were used to determine the most common concerns with discharging these patients. Response rate for this survey was 87% (118/135), of whom 56% (66/118) were residents and 24% (28/118) were faculty with 10 or more years of experience. The proportion who reported “comfort” with discharge of low-risk PE patients was 18% prior to establishment of clinic and 66% after 1 year (95% CI for difference of 48%: 43% to 54%). Of the patients approached for discharge, clinicians estimated that 81% agreed to immediate discharge instead of hospitalization (95% CI: 75% to 87%). Prior to the protocol, clinician comfort with discharge from the ED was inversely proportional to the number of years of experience (R2=0.144, P<.001). Physicians with more experience believed that the data supported safe discharge (R2=.062, P=.007), but were more likely to state that they needed to consult with an expert prior to discharge (R2=.047, P=.019). The physicians who were most uncomfortable with discharge prior to clinic reported having no safety concerns about sending patients home if they met criteria (R2=.060, P=.007). The largest concerns about discharging patients who met low-risk criteria were unfamiliarity with the process (40%), perceived expense of the TSA (33%), medicolegal liability (25%), feeling more comfortable if the patient was hospitalized anyway (21%), and ease of admission over discharge (20%). Twenty-three percent of respondents reported having none of the above concerns if patients met low-risk criteria. The majority (51%) of physicians identified follow-up as the major concern preventing discharge in the absence of our clinic. Establishment of reliable outpatient follow-up with a strict protocol for identifying low-risk PE patients has substantially increased clinician comfort with discharge. By clinician recall, the vast majority of patients choose discharge over hospitalization when given the option. Over half of clinicians identify availability of follow-up as the major impediment to discharging these patients. Emergency physicians highly prioritize the certainty of medical follow-up in their decision to use a home treatment protocol for ED patients with PE.