You have accessJournal of UrologyProstate Cancer: Localized I1 Apr 2010289 ASSOCIATION OF CIGARETTE SMOKING WITH TIME TO BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY: RESULTS FROM THE SEARCH DATABASE Daniel Moreira, Jodi Antonelli, Joseph Presti, William Aronson, Martha Terris, Christopher Kane, Christopher Amling, and Stephen Freedland Daniel MoreiraDaniel Moreira Durham, NC More articles by this author , Jodi AntonelliJodi Antonelli Durham, NC More articles by this author , Joseph PrestiJoseph Presti Palo Alto, CA More articles by this author , William AronsonWilliam Aronson Los Angeles, CA More articles by this author , Martha TerrisMartha Terris Augusta, NC More articles by this author , Christopher KaneChristopher Kane San Diego, CA More articles by this author , Christopher AmlingChristopher Amling Portland, OR More articles by this author , and Stephen FreedlandStephen Freedland Durham, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.351AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Cigarette smoking has been associated with increased incidence of several cancers; however, its correlation with prostate cancer remains unclear. Furthermore, the effects of smoking on response to prostate cancer treatments have only been evaluated in a limited number of studies of men treated with radiation only. Therefore, we sought to analyze the association between cigarette smoking and biochemical recurrence (BCR) after radical prostatectomy among men from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS Retrospective analysis of 1,267 subjects from SEARCH treated between 1998 and 2008 with available smoking status from pre-operative notes. Comparison of baseline patients' and disease characteristics between current smokers and nonsmokers (past and never smokers combined) was performed using chi-square for categorical data and rank-sum for continuous variables. Univariable and multivariable association between smoking status and BCR-free survival was analyzed using Kaplan-Meier plots, log-rank test and Cox proportional hazards. RESULTS A total of 408 (32%) were active smokers and 859 (68%) were nonsmokers at the time of surgery. Current smokers were significantly younger (P<0.001), more likely to be African American (P<0.001), had lower body mass index (P<0.001), higher percentage of positive biopsy cores (P=0.039), higher preoperative PSA (P=0.003) and higher incidence of extracapsular extension (P=0.003) and seminal vesicle invasion (P=0.029) and lower prostate volumes (P=0.002). In univariable analysis, smokers had a similar risk of biochemical recurrence as compared to nonsmokers (HR 1.19, P=0.129). In multivariable analysis, smoking was associated with increased risk of BCR when adjusted for BMI only (HR=1.37, P=0.008), though after adjustment for multiple pre-operative characteristics the association was attenuated and no longer statistically significant (HR=1.12, P=0.325). After additional adjustment for postoperative features such as tumor grade and stage, smoking was unrelated to risk of BCR (HR=0.91, P=0.502). CONCLUSIONS Among patients undergoing radical prostatectomy in SEARCH, cigarette smoking was associated with slightly more advanced disease but similar risk for BCR. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e114-e115 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Daniel Moreira Durham, NC More articles by this author Jodi Antonelli Durham, NC More articles by this author Joseph Presti Palo Alto, CA More articles by this author William Aronson Los Angeles, CA More articles by this author Martha Terris Augusta, NC More articles by this author Christopher Kane San Diego, CA More articles by this author Christopher Amling Portland, OR More articles by this author Stephen Freedland Durham, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...