With the rapid development of communication technology, the security and reliability of signal transmission and antiinterference ability have become a key challenge. Aiming at the problems, this paper deeply studies the scrambling and de-scrambling technique of pseudo-random sequences, and designed the corresponding circuit to better understand the working mode of each step. In this study, the design and implementation of the scrambling and de-scrambling technique of pseudo-random sequences circuit is carried out through Verilog language, and the advantages and disadvantages of the designed circuit are analyzed in detail and the improvement scheme is obtained. In addition, this study also compares and analyzes the advantages and disadvantages of the scrambling and de-scrambling technique of pseudorandom sequences and the scrambling and de-scrambling technique of self-synchronizing, which provides a reliable basis for selecting appropriate technical solutions in practical application scenarios. This study provides theoretical support and reference for the design of communication systems, and looks forward to the future development direction of the scrambling technology, including the development of more efficient algorithms, the exploration of adaptive techniques, and the development of low-power solutions.