When detecting epikarst water using the self-potential method, the actual location of the anomaly center often deviates from the prospecting result due to the interference of the regional background field, which is comprised of geological noise and artificial electromagnetic fields. Ultimately, this makes it difficult to locate the detection target accurately. To address the potential offset of the anomaly center location, in this study we introduce the differential filtering method into the data processing procedure. This method has smoothing and low-pass filtering effects, facilitating the extraction of meaningful anomalies. Meanwhile, based on the anomalous features of different physical parameters, we propose an integrated method system based on differentially filtered horizontal self-potential gradient data, the composite profile method, and the high-density electrical method, which can effectively improve the accuracy of anomaly localization. This newly established method system was applied at the Xiaguantun test site in Longzhou County, Chongzuo, Guangxi Province, China, and its effectiveness and feasibility was confirmed.