Aim: The purpose of this study was to investigate the consequences of pregnancy on women with CF and to clarify the impact of the disease on newborn health. Methods: It was a retrospective study; a postal questionnaire was sent to 12 woman having a registered pregnancy in National Cystic Fibrosis Registry between 1984 and 2004 (2 to 23 years after delivery). Results: There was a 100% response rate. 16 pregnancies have been reported (4 patients had two pregnancies); there were 16 live births of which 11 (69%) were premature, 10 (62%) of newborns had low weight. There was one neonatal death. The mean prepregnancy FEV 1 (% predicted) and BMI (kg/m2) were 56,6±14,8% (range 35-95) and 19,9±1,5 (range 18-23) respectively. The mean FEV 1 during pregnancy was 47,7±15,1% (range 23-87), mean maternal weight gain during pregnancy was 5,5kg. There was a significant decline in FEV 1 during pregnancy (16,6±6,4 %, p 1 was 54,1±18,8% (range 22-103) and mean BMI was 18,7±1,8 kg/m2 (range 15-22). There was a significant postpregnancy decline in FEV 1 (6,2±10,6%, p=0,027) and in BMI (1±1,14 kg/m2, p Conclusions: Pregnancy was well tolerated in our population of CF women, although affected the rate of yearly decline in FEV 1 and BMI. Increased risk of premature and low newborn weight were observed. All pregnancies in CF women should be planned and monitored by CF team. Pneumonol. Alergol. Pol. 2005, 73, 71-75 .