Purpose Previous studies have indicated that the Model for End-stage Liver Disease (MELD) score as a metric for liver congestion and right heart failure predicts survival in patients undergoing left ventricular assist device (LVAD) implantation. The predictive value of the MELD has never been evaluated for predicting postoperative survival for patients implanted with the total artificial heart (TAH), where right heart failure does not exist. The goal was to evaluate the preoperative MELD for predicting survival after TAH. Methods This was a single center study that analyzed 100 patients who were implanted with the TAH between March 2006 and March 2017. We calculated the preoperative MELD scores using laboratory data closest to device implantation and compared a high and low MELD group using the median value as a cutoff. Results The median MELD score was 14.4 (IQR: 12.2, 19.4) and patients in the high and low MELD groups were of similar age and proportion of male gender and Caucasian race. Patients with a higher MELD score had lower eGFR (72.5 ± 20.8 vs 45.8 ± 30.8 mL/min/1.73 m², p Conclusion The MELD score was not predictive of mortality in patients undergoing TAH implantation. These data may reflect the benefits of bi-ventricular replacement in a patient population exhibiting laboratory data associated with congestive hepatopathy, however the analysis must be applied in a larger patient cohort for validation.