Blood transfusions have traditionally been associated with the management of anemia in individuals living with HIV; however, their potential role as a complementary approach in reducing viral load impact is gaining attention. This review explores how blood transfusions can enhance immune function, improve oxygen delivery, and support the efficacy of antiretroviral therapy (ART), thereby contributing to better health outcomes for patients. By addressing complications associated with HIV, such as anemia and immune dysfunction, blood transfusions may play a crucial role in optimizing treatment strategies and enhancing the overall quality of life for individuals living with the virus. The relationship between viral load and immune function is critical in HIV management, as high viral loads are associated with increased morbidity and mortality. Blood transfusions can mitigate the negative effects of viral load by improving the physiological conditions necessary for an effective immune response. Enhanced oxygenation from transfusions supports immune cell proliferation and activity, potentially leading to better control of viral replication and lower viral load levels. Moreover, improving hemoglobin levels through transfusions can reduce fatigue, increase treatment adherence, and promote active participation in ART. Keywords: anemia, blood transfusions, HIV, immune response, viral load