Abstract One year of Spread spectrum Interferometric Multistatic meteor radar Observing Network (SIMONe) measurements are analyzed and compared for the first time between two low-latitude locations in Peru: Jicamarca (12°S, 77°W) and Piura (5°S, 80°W). Investigation of the mean horizontal winds and tides reveals that mesosphere and lower thermosphere (MLT) planetary-scale dynamics are similar between these two locations, although differences can be seen in some tidal components, e.g., the diurnal tide. On the other hand, 28-day median values of the momentum fluxes obtained with 4-h, 4-km time–altitude bins indicate that the mesoscale dynamics differ significantly between Jicamarca and Piura, places separated by approximately 850 km. From the middle of July until October 2021, a strong acceleration of the background zonal wind by westward-propagating gravity waves (GWs) is observed above ∼90 km at both locations, although with larger amplitudes over Jicamarca. From the middle of January until April 2022, a second strong acceleration of the background zonal wind, again by westward-propagating GWs, is observed, but this time with larger amplitudes over Piura. The latter is further supported by the dominance of negative vertical gradients of the zonal momentum flux above 89 km of altitude. Thus, these results observationally confirm the previous studies based on general circulation model simulations indicating that the directions of the zonal GW drag and the zonal background wind coincide in the low-latitude MLT. The weak correlations between the horizontal wind gradients over Jicamarca and Piura reinforce the fact that the mesoscale dynamics are different at these two locations.