Low Injection Research Articles

Abstract Mo135: Correlation of Leptin Resistance With Attenuation of Cardiac Vagal Activation in Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is one of the most prominent diseases impacting individuals worldwide. A leading cause of death for T2DM patients is MI-related ventricular arrhythmia, which is associated with cardiac vagal nerve dysfunction. As T2DM patients exhibit leptin resistance, and leptin signaling has been implicated in heart rate regulation, we set out to characterize changes in cardiac vagal ganglionic neuron activity during development of T2DM and determine leptin signaling’s role in cardiac vagal dysfunction. In this study, T2DM was induced in Sprague-Dawley rats by feeding a high fat diet (HFD) plus a low dose streptozotocin injection. To characterize cardiac dysfunction, we measured arterial baroreflex sensitivity and found that 12 wks post-T2DM induction, rats experienced a diminished baroreflex response (gain max 0.62 ± 0.04 bpm/mm Hg T2DM vs. 2.21 ± 0.14 bpm/mm Hg sham). To determine if the change in baroreflex sensitivity is due to altered cardiac vagal nerve activity, we measured nAChR currents and cell excitability in intracardiac ganglion (ICG) neurons and found that T2DM rat cardiac vagal neurons exhibited reduced nAChR current density (213.9 ± 25.6 pA/pF T2DM vs. 375.5 ± 44.3 pA/pF sham) and action potential frequency (9.1 ± 0.5 spikes/s T2DM vs. 19.9 ± 1.4 spikes/s sham). Furthermore, acetylcholine release from cardiac vagal nerve terminals was attenuated in T2DM rats (0.4 ± 0.16 nM T2DM vs. 1.07 ± 0.12 nM sham). To determine the role of leptin signaling in the decrease of cardiac vagal nerve activity, we examined leptin and leptin receptor levels in ICG at 4, 8, and 12 wks post-T2DM induction. Western blots revealed elevated ICG leptin levels at 4, 8, and 12 wks post-T2DM induction (8.9 ± 0.7, 9.1 ± 1.3, and 11.7 ± 2.1 times sham level, respectively). qRT-PCR revealed reduced levels of leptin receptor transcript at 12 wks post-T2DM induction (48 ± 12% of sham). A reduction of leptin receptor protein in ICG neurons at 12 wks post-T2DM induction was observed using IF microscopy. These data demonstrate that T2DM reduces cardiac vagal nerve activity resulting in diminished control of cardiac functions such as the baroreflex. Furthermore, leptin resistance may play a role in this diminished cardiac function through reductions in leptin receptor levels.

Dual polarization for efficient III-nitride-based deep ultraviolet micro-LEDs

The deep ultraviolet (DUV) micro-light emitting diode (μLED) has serious electron leakage and low hole injection efficiency. Meanwhile, with the decrease in the size of the LED chip, the plasma-assisted dry etching process will cause damage to the side wall of the mesa, which will form a carrier leakage channel and produce non-radiative recombination. All of these will reduce the photoelectric performance of μLED. To this end, this study introduces polarized bulk charges into the hole supply layer (p-HSL) and the electron supply layer (n-ESL) respectively (dual-polarized structure) of the DUV μLED at an emission wavelength of 279 nm to enhance the binding of carriers and increase the injection efficiency of carriers. This is because the polarization-induced bulk charge can shield the polarized sheet charge on the interface and reduce the polarization electric field. The reduced polarization electric field in p-HSL can increase the effective barrier height of the conduction band in the p-type region and reduce the effective barrier height of the valence band. The decrease in the polarized electric field of n-HSL can reduce the thermal velocity of electrons, thereby enhancing the electron injection efficiency, reducing the Shockley–Read–Hall (SRH) recombination, and increasing the effective barrier height of the valence band. The study results indicate that the electron concentration and hole concentration of a μLED with dual polarization were increased by 77.93% and 93.6%, respectively. The optical power and maximum external quantum efficiency of μLED reached 31.04 W/cm2 and 2.91% respectively, and the efficiency droop is only 2.06% at 120 A/cm2. These results provide a new approach to solving the problem of insufficient carrier injection and SRH recombination in high-performance DUV μLEDs.

Numerical Simulation of Radiatively Driven Transonic Relativistic Jets

We perform the numerical simulations of axisymmetric, relativistic, optically thin jets under the influence of the radiation field of an accretion disk. We show that starting from a very low injection velocity at the base, jets can be accelerated to relativistic terminal speeds when traveling through the radiation field. The jet gains momentum through the interaction with the radiation field. We use a relativistic equation of state for multispecies plasma, which self-consistently calculates the adiabatic index for the jet material. All the jet solutions obtained are transonic in nature. In addition to the acceleration of the jet to relativistic speeds, our results show that the radiation field also acts as a collimating agent. The jets remain well collimated under the effect of radiation pressure. We also show that if the jet starts with a rotational velocity, the radiation field will reduce the angular momentum of the jet beam.

Modeling on ball migration and seating in a horizontal well with multi-cluster perforations

Ball-throwing temporary plugging fracturing is a new technology for achieving uniform-length fracture in a horizontal well. The migration and seating law of a temporary plugging ball (TPB) in the horizontal well is still not clear. Based on the computational fluid dynamics-discrete phase model coupling method, a three-cluster spiral perforated borehole model is established to analyze the effects of the density, diameter, and number of TPB, fracturing fluid injection rate, and viscosity on the migration and seating behaviors of TPB. The results show that the buoyancy ball and the gravity ball have better sealing effects on cluster 3, which is near the borehole heel, and cluster 1, which is near the borehole toe, respectively. When the diameter of TPB is 1–1.3 times the perforation diameter, the overall plugging effect is better. When the number of TPB is 5/6 times the total number of perforations, the plugging effect at cluster 3 and cluster 1 is better. When the injection rate of fracturing fluid ranges from 0.5 to 2.5 m3/min, the plugging efficiency at cluster 3 is higher with a low injection rate. When the viscosity of the fracturing fluid is 20–30 mPa s, cluster 3 and cluster 1 have better plugging effect.

Experimental study on upstream pressure characteristics of rotating detonation engine with methane and oxygen-enriched air

The interaction mechanism between the rotating detonation engine (RDE) and its upstream is one key issue that needs to be explored when considering its application. In this study, experimental tests with methane and 50% oxygen-enriched air are conducted to investigate the relationship between upstream pressure characteristics and the detonation wave. As a result of operational considerations, a hollow chamber and a rear ignitor are used and the initiation process is discussed. Upstream pressure characteristics are analyzed under varied injection pressures and equivalence ratios. Stable modes including single-wave and double-wave modes are recorded in most cases. Notably, two unstable modes are also captured at low injection pressure in which the detonation quenches quickly. The results highlight that significant feedback pressure pulsations synchronize with the rotation frequency of detonation waves after ignition due to the upstream oblique shock wave (UOSW). But the inherent frequency of injection should also be emphasized at elevated injection pressure. The detonation wave can also cause injection blockage, particularly at low injection pressure, leading to the bifurcation of unstable mode. Such unstable is attributed to an inadequate upstream pressure increase after ignition, which hinders the injection reconstruction. Further analysis reveals that higher injection pressures or lower equivalence ratios diminish the differential between the detonation wave and upstream pressure, and consequently, the pulsation amplitude. An increase in the detonation wave number can also reduce the pulsation amplitude, which can even be lower than 10% in a double-wave mode. The results are beneficial for integrating RDE and its upstream components.

Nanozyme-enhanced mitophagy to improve the efficacy of mesenchymal stem cells in myocardial infarction therapy

Mesenchymal stem cell therapy has emerged as a promising approach for the treatment of myocardial infarction. However, the challenge of low cell survival and retention post injection, particularly under the high levels of reactive oxygen species (ROS) and oxidative stress at the infarct site, has hindered their clinical application. Additionally, traditional drug delivery methods, such as intravenous injection, cannot meet the demand for long-term stem cell residence at the infarct site, which is another critical issue that impedes the therapeutic efficacy of stem cells. Herein, we synthesized indocyanine green-enriched Prussian blue nanozyme, called PB@PEI@ICG, which not only possessed remarkable ROS scavenging capability but also exhibited superior fluorescent tracer property. Subsequently, we engineered mesenchymal stem cells (MSCs) with PB@PEI@ICG by co-culture and found that the introduction of the nanozyme significantly enhanced mitophagy by BNIP3 and PINK1 pathways, which in turn promoted ROS scavenging and protected MSCs from cell death induced by the harsh infarct microenvironment. Furthermore, we employed pericardial injection as an alternative delivery method to prolong the residence time of MSCs at the infarct site, enabling real-time tracking via the fluorescence property of the nanozymes. The results demonstrated that PB@PEI@ICG nanozyme could significantly improve the survival and retention of MSCs at the infarct site, thereby enhancing the therapeutic effect for myocardial infarction. In conclusion, this study presents a novel strategy for stem cell therapy in myocardial infarction by using mitophagy-enhancing nanozyme to scavenge ROS for enhancing the therapeutic potential of stem cells.

Convective Heat Transfer Analysis of Supercritical CO2 in Artificial Rock Fractures

Geothermal energy has emerged as a promising renewable and sustainable resource. This research article explores the utilization of supercritical CO2 and convective heat transfer in porous rock to enhance geothermal extraction. Artificial cement rock with a smooth and manmade slotted surface fracture was used as a working sample for heat transfer source in the test. Heat transfer characteristics under various flow rates, fluid inlet temperature and pressure, rock initial temperature are analyzed. The results indicate that the geometry characteristics of fracture surface impact the overall heat transfer intensity to a certain extent, whereas lithology has little influence on the heat transfer intensity. In addition, it is found that increasing injection pressure affects the operating temperature and density of the injected fluid, which helps to improve the production effect, to obtain more heat. However, limited by the heat transfer area, low injection flow is required. The maximum error of the heat transfer coefficient model is 7.05% compared with the empirical value and less than 10% compared with the experimental results. By examining the interaction between fluid and porous fractures, we aim to provide insights into the potential of these techniques for maximizing energy efficiency and tapping into deep geothermal resources.

Visualization study on the flame propagation and distribution characteristics and exploration of optimal injection strategy in ammonia/diesel dual direct injection mode

With the increasing shortage of fossil fuels and the worsening carbon emission problems, ammonia has been attracted widely to alleviate the current challenges faced by internal combustion engines. Igniting direct injection of liquid ammonia by diesel may be a measure to achieve effective ammonia application, while the research on the characteristics of combustion and the unburned ammonia emission is little. Therefore, this paper studies the effects of ambient parameters and injection parameters on the characteristics of diesel ignition and flame propagation and distribution based on a constant volume combustion chamber, through the shadow method. The results indicate that the premise to ensure that ammonia can fully participate in combustion is that the flame can backpropagate to the junction of the two sprays. The current optimal injection strategy is the simultaneous injection of diesel and ammonia combined with a complete ammonia injection before the maintained flame. At a low temperature and high diesel injection pressure, ammonia will participate in combustion after a delay, which may result in a relatively low heat release rate and high unburned ammonia emissions. Overall, the paper can provide important references for professional researchers which is of great significance for the development of diesel/ammonia engines.

Aflibercept in a real-world setting: the AURIGA study : 24-month results of the German cohort of treatment-naïve patients with macular edema following retinal vein occlusion receiving intravitreal aflibercept

AURIGA is the largest prospective real-world study to evaluate intravitreal aflibercept 2 mg (IVT-AFL) treatment of macular edema (ME) secondary to retinal vein occlusion (RVO) and diabetic macular edema. Here we present the 24-month data from the German cohort of treatment-naïve patients with ME due to RVO. Treatment-naïve patients with ME secondary to RVO were treated with IVT-AFL 2 mg in the routine clinical practice. The primary endpoint was mean change in visual acuity (VA, early treatment diabetic retinopathy, ETDRS, letters) at month12 compared to baseline. Analyses were descriptive. Analysis included 130 patients with RVO (n = 61, 46.9% with central RVO, n = 69, 53.1% with branch RVO). The mean (±SD) time the RVO patients remained in the study was 18.4 ± 7.4months. The mean VA gain (95% confidence interval) in the overall cohort was +10.9 (7.5-14.2) letters at month12 and +9.7 (6.1-13.3) at month24 (baseline VA 56.5 ± 18.9 letters). At 24months, 67% of RVO patients gained ≥5letters and 40% gained ≥15letters. The mean number of injections was 4.4 ± 1.3 up to month6, 6.2 ± 2.7 up to month12 and8.2 ± 4.5 up to month24. The mean central retinal thickness (CRT) reduction was -206µm (-252 to -160µm) at 12months and -219µm (-263 to -175µm) at 24months (baseline CRT 507 ± 177 µm). The safety profile was consistent with that of previous studies. In the German AURIGA cohort of treatment-naïve patients with ME secondary to RVO, IVT-AFL 2 mg treatment in clinical practice resulted in rapid and clinically relevant VA gains and areduction in CRT. These results were largely maintained over 24months despite the low injection frequency from month6.

Lean Blowout Proximity Sensing in a Low Emission Liquid-Fueled Combustor

ABSTRACT Advanced aircraft engine combustor designs, intended for achieving low NOx emissions, necessitate lean combustion with small operating margins above the LBO boundary, posing a high risk of exhibiting lean blowout (LBO) problems. Employing active LBO controllers receiving input from LBO proximity sensors can allow for narrower margins, thereby yielding multiple performance gains. Although several previous studies investigated LBO proximity sensing, they predominantly focused on premixed gas-fueled combustors. The application of proximity sensing approaches to liquid-fueled combustor designs, relevant to aircraft engines have not received adequate attention. Therefore, this study investigates LBO proximity sensing in a low emission lean direct injection (LDI) liquid-fueled combustor design developed by NASA. The combustor operates at atmospheric pressure with preheated air. The proximity sensing is examined by analyzing both OH* and CH* chemiluminescence signals, with a focus on assessing their relative performances. The signal analysis approaches include spectral, partial extinction event (LBO precursor) detection, signal RMS, and the CH*/OH* ratio, with an emphasis on the first two methods. Both steady-state and transient operating conditions have been examined. The combustor did not exhibit large-scale flame partial extinction and re-ignition events near LBO, as commonly observed in gas-fueled combustors. However, an increase in flame unsteadiness and partial extinction events with very subtle signatures in optical signals, have been observed. Low-pass filtering has been observed to considerably enhance the precursor signatures enabling their improved detection. With a reduction in LBO margin, an increase in signal low-frequency power, RMS, and precursor event occurrence rate have been observed, which were utilized for providing LBO proximity measures. A key finding from this study is that CH* signals provide significantly superior performance compared to OH* for the proximity sensing in all the approaches, and the potential reasons are discussed.

Efficient In Situ Doping of Strained Germanium Tin Epilayers at Unusually Low Temperature

AbstractEfficient p‐ and n‐type in situ doping of compressively strained germanium tin (Ge1‐xSnx) semiconductor epilayers, grown by chemical vapor deposition on a standard Si(001) substrate, is demonstrated. Materials characterization results reveal unusual impact of dopants manifesting via a pronounced reduction of Sn content in the epilayer, accompanied by an enhancement of the growth rate, due to increasing p‐type doping concentration. Furthermore, the opposite behavior for n‐type doping is observed, resulting in a less pronounced increase of Sn concentration and no effect on growth rate. Nevertheless, a very high density of electrically active holes up to ≈4 × 1020 cm−3 is obtained in p‐type doped Ge1‐xSnx epilayer resulting in the lowest resistivity of 0.15 mΩ cm among all in situ doped epitaxial and strained group‐IV semiconductors. Also, the metal‐to‐insulator transition in Ge1‐xSnx is experimentally demonstrated for doping levels above 1 × 1017 cm−3, which is substantially lower than in any group‐IV semiconductor, and theoretically predict it to be as low as ≈1 × 1017 cm−3. The findings enabled by the doping regime explored in this work can open novel prospects to engineer low resistivity contacts and charge current injection in applications covering next‐generation transistors, qubits, diodes, electrically driven light sources, sensors and hybrid quantum devices.

Compatibility of divertor detachment and ELM suppression in DIII-D high- βp plasmas with ITER-similar shape

Integration of transient and steady-state divertor heat fluxes control with a high-performance core is necessary for future fusion reactors. In recent DIII-D high- βp experiments, divertor detachment and simultaneous edge localized mode (ELM) suppression are demonstrated while the plasma confinement quality is maintained high in ITER-similar shape. By optimizing the neon injection in high- βp scenario with ITER-similar shape, deep detachment and ELM suppression are achieved with a high-performance core ( βN ∼ 2.8, βp ∼ 2.3) at q95 ∼ 7.5. Partial divertor detachment and suppression of large ELMs are achieved at q95 ∼ 6. The stability analyses suggest that with low neon injection, the density pedestal becomes higher and steeper and the Ti profile also increases, therefore the increased edge pressure and higher current density destabilize the Peeling-Ballooning mode (PBM), which would lead to a large ELM collapse. With strong neon gas puffing, the significantly reduced pedestal pressure and current density, due to the degraded Te pedestal, lead to the stabilization of PBM and ELMs are suppressed. For both cases, the coupling between the large radius internal transport barrier (ITB) and edge pedestal is the key reason for maintaining high global performance. The formation of large radius ITB compensates for pedestal degradation. Such results could provide an attractive scenario to well control the transient and steady-state heat flux onto the divertor plates while maintaining good plasma performance, which is an important step toward the steady-state operation of future fusion reactors.

Comparison of Metabolic Changes after 6 Months of High-Carbohydrate Diet or High-Fat Diet with Low Dose Streptozotocin Injection in Rats.

We compared 2 models of metabolic syndrome in rats: high-fat diet (58% calories) with single streptozotocin injection at a dose of 25 mg/kg and replacement of water with 20% fructose solution. The model with fructose solution did not cause the main signs of metabolic syndrome over 24 weeks: concentrations of glucose, triglycerides, cholesterol, weight, and BP did not significantly differ from the control group (standard diet). At the same time, single streptozotocin administration was followed by the development of persistent hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and signs of visceral obesity. High-fat diet combined with injection of streptozotocin in a low dose can be considered a more representative model of metabolic syndrome in humans.

Formulation and characterization of ionically crosslinked gellan gum hydrogels using trilysine at low temperatures for antibody delivery

Research of the nontraditional polysaccharide gellan gum (GG) is a growing space for the development of novel drug delivery systems due to its tunable physic-mechanical properties, biocompatibility, and stability in a wide range of environments. Unfortunately, high temperature crosslinking is often required, representing a limiting factor for the incorporation of thermosensitive therapeutic agents. Here, we demonstrated that GG can be crosslinked at a low temperature (38 °C) using a simple fabrication process that utilizes trilysine as an alternative to traditional mono- or divalent ion crosslinkers. While elevated temperature mixing is still required to form a clear GG solution, crosslinking of 0.5 – 1 % GG (w/v) in the presence of trilysine (0.03 % - 0.05 % w/v) was achieved at 38 °C resulting in hydrogels with suitable working formulations to facilitate syringe loading. Low injection forces (< 20 N), and biocompatibility was evaluated with normal human dermal fibroblast (cell viability > 90 %). Frequency sweep showed a transition from purely liquid-like behavior to gel-like behavior with increased trilysine concentration. A temperature dependent behavior was lost with higher trilysine concentrations, indicating stable hydrogel formation. NMR results suggest that trilysine participates in gelation via both ionic interactions between the primary amines of trilysine and the carboxylate residues of glucuronic acid and hydrogen bonding. Released studies showed that GG hydrogels can entrap and provide sustained release of IgG in relation to the crosslinker, and antibody concentration used, with a burst release within the first 24 h (∼80 % cumulative released) followed by a sustained released for up to 5 days. Overall, findings demonstrate a promising nontoxic injectable hydrogel that requires lower crosslinking temperatures, is simple to manufacture and serves as a carrier of thermosensitive therapeutic agents.

Ultra‐high bonding strength of carbon fiber–doped polyamide–aluminum alloy composite structure achieved by changing crystallinity

AbstractLightweight and high‐strength polymer–metal hybrid structures are favored for reducing material and energy consumption. In this study, carbon fiber‐reinforced polyamide 6 (CFPA) composite materials were prepared through melt blending, and 30 wt% CFPA exhibited the highest shear strength and lowest shrinkage rate among other carbon fiber contents. With pretreatments of anodizing and etching treatment, injection molded direct joining was employed to create polyamide 6 (PA)/CFPA–Aluminum alloy (Al) composites. The impacts of the injection temperature and speed on the bonding strength of the PA/CFPA–Al composite materials were investigated. The characterization results confirmed that carbon fiber doping reduces the coefficient of linear thermal expansion (CLTE) and enhances crystallization ability of PA. The higher injection temperatures and lower injection speed significantly increase the crystallinity of PA and the infiltration of the molten polymer into the nanoporous anodic aluminum oxide films. When the injection temperature was 270°C and the speed was 6 mm/s, the bonding strength of the PA–Al hybrid structure reached a maximum of 36.6 MPa. When the injection temperature was 300°C, the bonding strength of the CFPA–Al hybrid structure reached a maximum of 40.8 MPa. Adhesive parts with high shear bonding strength are critical to satisfying engineering requirements and have significant potential, particularly in polymer–metal composite structures. The polymer‐metal hybrid structure can meet the high interfacial bonding strength required in most engineering applications.Highlights Injection temperature and speed in IMDJ affect PA crystallinity. Carbon fiber doping reduces the CLTE of PA and increases the shear strength. High temperatures and low injection speeds are beneficial to adhesives. The bonding strength of PA–Al reached a maximum of 36.6 MPa. The bonding strength of CFPA–Al reached a maximum of 40.8 MPa.

Advantages of AlGaN Tunnel Junction in N-Polar 284 nm Ultraviolet-B Light Emitting Diode

Smart, low cost and environmentally safe aluminum gallium nitride (AlGaN)-based ultraviolet-B light-emitting diodes (UV-B LEDs) are promising in real-world applications including medical as well as agricultural sciences. Higher efficiency droops, low hole injection efficiency, and high operating voltage are the key problems that AlGaN-based UV-B LEDs are facing. In this work, a smart and clean AlGaN-based UV-B LED at 284 nm emission wavelength has been studied. Here an approach is presented to electrically operate the quantum tunnelling probability by exploiting the transported carriers at the interface of p-AlGaN/n-AlGaN/n++-AlGaN tunnel junction (TJ) with moderate Si and Mg-doping levels and optimized thickness with the help of simulation study. The simulation results show that the Augur recombination rate is successfully suppressed and quite a high radiative recombination rate is achieved in the 284 nm N-polar AlGaN-based TJ UV-B LEDs, which is attributed to the improved hole injection toward the MQWs when compared to C-LED (conventional-LED). It is found that C-LED has a maximum IQE (internal quantum efficiency) of 40% under 200 A cm−2 injection current with an efficiency drop of 15%, while the TJ-LED has a maximum IQE of 93% with an efficiency droop of 0%. In addition, TJ-based AlGaN LED emitted power has been improved by 6 times compared to the C-LED structure. The emitted powers of TJ-LED increase linearly under varying current densities, whereas in the case of C-LED, the emitted power changes nonlinearly under varying current densities. This is attributed to the lower Augur recombination rate in the MQWs of N-AlGaN-based TJ UV-B LED. The operating voltages were reduced from 5.2 V to 4.1 V under 200 mA operation, which is attributed to the thickness and doping optimization in TJ and better selection of relatively lower Al-content in the contact layer. N-polar AlGaN-based TJ is explored for UV-B LEDs and the demonstrated work opens the door to epitaxial growth of high-performance UV emitters in MOCVD and MBE for a plethora of biomedical applications.

Impact of injection pressure and polyaxial stress on hydraulic fracture propagation and permeability evolution in graywacke: Insights from discrete element models of a laboratory test

Understanding the hydromechanical behavior and permeability stress sensitivity of hydraulic fractures is fundamental for geotechnical applications associated with fluid injection. This paper presents a three-dimensional (3D) benchmark model of a laboratory experiment on graywacke to examine the dynamic hydraulic fracturing process under a polyaxial stress state. In the numerical model, injection pressures after breakdown (postbreakdown) are varied to study the impact on fracture growth. The fluid pressure front and crack front are identified in the numerical model to analyze the dynamic relationship between fluid diffusion and fracture propagation. Following the hydraulic fracturing test, the polyaxial stresses are rotated to investigate the influence of the stress field rotation on the fracture slip behavior and permeability. The results show that fracture propagation guides fluid diffusion under a high postbreakdown injection pressure. The crack front runs ahead of the fluid pressure front. Under a low postbreakdown injection pressure, the fluid pressure front gradually reaches the crack front, and fluid diffusion is the main driving factor of fracture propagation. Under polyaxial stress conditions, fluid injection not only opens tensile fractures but also induces hydroshearing. When the polyaxial stress is rotated, the fracture slip direction of a fully extended fracture is consistent with the shear stress direction. The fracture slip direction of a partly extended fracture is influenced by the increase in shear stress. Normal stress affects the permeability evolution by changing the average mechanical aperture. Shear stress can induce shearing and sliding on the fracture plane, thereby increasing permeability.

P‐216: The Status and Trend of Narrow‐bezel OLED Display

With the development of display technology, the terminal customer has put forward higher panel specification requirements. As a result, smart phone's panel size becomes bigger and bigger, as well as the screen ratio, which lead to sharp decrease in panel border size. While limited by the space and module structure, how to accomplish narrow bezel is always a hot topic in OLED field. During the past two years, panel makers used LIPO（Low injection pressure overmolding） technology to make border narrower, and this become standard configuration settings. However, LIPO accounts for little proportion in total panel and module border, it is the reduction for the space between the shell and module. In this paper, we analyze the trend of narrow bezel development, and introduce some new methods which may be used in future, hoping to provide some helpful reference to OLED panel narrow bezel design.

Pattern transition of flow dynamics in a highly water-absorbent granular bed

An aqueous sodium chloride solution was injected at a controlled rate into a granular bed in a quasi-two-dimensional cell. The granular bed was made of dried, highly water-absorbent gel particles whose swelling rate was controlled by the salinity of the injected fluid. At a high salinity level (low swelling rate), high injection rate, and short timescale, the injected fluid percolated between the gel particles in an isotropic manner. Meanwhile, at a low salinity level (high swelling rate), low injection rate, and long timescale, the gel particles clogged the flow path, resulting in anisotropic branch-like structures of the injected fluid front. The transition of the injection pattern could be understood based on the ratio of the characteristic timescales of swelling and injection. Moreover, the clogged pattern showed an oscillatory pressure drop whose amplitude was increased with higher salinity. Such an oscillatory behavior observed in an injection process in swelling gel particles may be relevant in geological situation, such as fluid migration underground.

LOW SALINITY WATER INJECTION EVALUATION AND MATURE FIELD DEVELOPMENT AT ANGGORO SHALLOW SAND, SANGASANGA FIELD

AbstractAnggoro's shallow sand was perforated at well ANG-1033 (D4-N1 layer). Oil production in this well increased from an average of 15 BOPD to 170 BOPD. That the perforated layer was affected by low salinity water injection (salinity &lt; 3000 ppm). Evaluation of water injection sweep efficiency was carried out using the Dykstra-Parson method, vertical efficiency of about 0.3, area efficiency of 0.7, and displacement efficiency of 0.3. The Estimated Ultimate Recovery (EUR) of this well provides is 197 MBbls with an additional RF of around 20 %. This increase is due to the low salinity water injection sweep mechanism that occurs. The clay content plays an important role in the mechanism that occurs in this layer, these mechanisms fines migration, increase in pH, multi ion exchange, double layer effect, and salting in which these mechanisms result in increased oil recovery. Seeing the production results from the D4-N1 layer and oil production in this layer can still be maximized, in the future this layer can be developed with several programs such as reactivation, workover, and development drilling.Keywords: Low salinity water injection, shallow layer, efficiency