Low Index Research Articles

Association of Metabolic Syndrome or Weather Conditions with the Severity and Prognosis of Sudden Sensorineural Hearing Loss.

It is reported that sudden sensorineural hearing loss (SSNHL) is closely related to diabetes, hypertension, and hyperlipidemia. While the metabolic syndrome (MetS) is a multifactorial disease that includes diabetes, hypertension, dyslipidemia, and obesity, which are known to be associated with SSNHL. Weather conditions have long been known to affect the SSNHL. This study aimed to make a clear connection between MetS, or weather conditions, and the severity and prognosis of SSNHL. 127 SSNHL patients have been divided into the MetS group and the non-MetS group, and the demographic and clinical characteristics of the 2 groups have been analyzed retrospectively. There were 52 (40.9%) patients in the MetS group, while there were 75 (59.1%) patients in the non-MetS group. The rate of vertigo, hypertension, diabetes, lower high-density lipoprotein cholesterol (HDL-C) levels, high triglyceride (TG), and body mass index (BMI) ≥25 (kg/m2 ) were significantly higher in the MetS group than those in non-MetS group. Vertigo, hypertension, and Mets were linked to the severity of hearing loss. The rate of complete recovery and partial recovery in the MetS group was clearly lower than that in non-MetS group. According to the multivariate analysis, MetS was significantly associated with a poorer prognosis of SSNHL; a high ambient temperature difference at onset and hypertension were correlated with a poor prognosis. These results demonstrate that the severity and prognosis of SSNHL can be influenced by the MetS. High ambient temperature differences at onset and hypertension were indicators of a poor prognosis for SSNHL.

Associations of schooling type, qualification type and subsequent health in mid-adulthood: evidence from the 1970 British Cohort Study

BackgroundEducation is thought to benefit health. However, existing studies have predominantly focused on educational attainment—the type of institution attended has been overlooked, despite being an important indicator of education resources,...

Edukasi Gizi Seimbang Sebagai upaya Pencegahan Stunting oleh KKN Universitas Palangka Raya di Desa Batuah Kecamatan Basarang Kabupaten Kapuas

Stunting is a condition of impaired growth in children under five years of age due to chronic malnutrition, resulting in slower growth compared to their peers. Based on the Special Index Report on Stunting Management in Central Kalimantan Province for 2021-2022, it shows that almost every city and district has reached the index threshold but is indicated to be low or the index numbers are close to the lower limit. The IKPS (Special Stunting Management Index) for Kapuas Regency in 2021 reached 51.7 with a lower limit index of 47.0, categorized as poor, and in 2022 it only reached 49.2 with a lower limit index of 43.9, also categorized as poor. The KKN group designed several educational and nutritional intervention programs to increase community awareness and understanding of the importance of adequate and balanced nutritional intake. These programs include socialization about healthy eating patterns, counseling on the importance of nutrition for pregnant and breastfeeding mothers, and the provision of healthy corn pudding. The output of this activity is demonstrated by the increased knowledge of participants about the importance of adequate nutrition.

VEGF-A165a and angiopoietin-2 differently affect the barrier formed by retinal endothelial cells

Exposure to VEGF-A165a over several days leads to a persistent dysfunction of the very tight barrier formed by immortalized endothelial cells of the bovine retina (iBREC). Elevated permeability of the barrier is indicated by low cell index values determined by electric cell-substrate impedance measurements, by lower amounts of claudin-1, and by disruption of the homogenous and continuous staining of vascular endothelial cadherin at the plasma membrane. Because of findings that suggest modulation of VEGF-A's detrimental effects on the inner blood-retina barrier by the angiogenic growth factor angiopoietin-2, we investigated in more detail in vitro whether this growth factor indeed changes the stability of the barrier formed by retinal endothelial cells or modulates effects of VEGF-A. In view of the clinical relevance of anti-VEGF therapy, we also studied whether blocking VEGF-A-driven signaling is sufficient to prevent barrier dysfunction induced by a combination of both growth factors. Although angiopoietin-2 stimulated proliferation of iBREC, the formed barrier was not weakened at a concentration of 3 nM: Cell index values remained high and expression or subcellular localization of claudin-1 and vascular endothelial cadherin, respectively, were not affected. Angiopoietin-2 enhanced the changes induced by VEGF-A165a and this was more pronounced at lower concentrations of VEGF-A165a. Specific inhibition of the VEGF receptors with tivozanib as well as interfering with binding of VEGF-A to its receptors with bevacizumab prevented the detrimental effects of the growth factors; dual binding of angiopoietin-2 and VEGF-A by faricimab was marginally more efficient. Uptake of extracellular angiopoietin-2 by iBREC can be efficiently prevented by addition of faricimab which is also internalized by the cells. Exposure of the cells to faricimab over several days stabilized their barrier, confirming that inhibition of VEGF-A signaling is not harmful to this cell type. Taken together, our results confirm the dominant role of VEGF-A165a in processes resulting in increased permeability of retinal endothelial cells in which angiopoietin-2 might play a minor modulating role.

Effect of heat treatment on the stability of ultrasound-assisted cross-linked myofibrillar protein-stabilized emulsion filler phases via rheology and tribology

This work aimed to reveal the effect of heat treatment on the stability of ultrasound-assisted cross-linked myofibrillar protein-stabilized emulsion and its potential application as a filler phase. The interfacial dilatational rheology, emulsion droplets, linear and nonlinear shear rheological properties, microrheological properties, and tribological properties of emulsion fabricated by the original myofibrillar protein (MP) (NA), crosslinked MP (NAG), and sonication after crosslinked MP (MPGU) were determined at the heat temperature of 40 °C, 60 °C, and 80 °C. Results indicated that heat treatment would affect the stability and processing adaptability of the emulsion. The elasticity and strength of the interfacial film were enhanced with the treated temperature increased from 40 °C to 80 °C, and the MPGU group showed a more linear shape of interfacial Lissajous plot than the other groups even at large amplitudes. Based on the good interfacial properties, the MPGU group had the smaller emulsion droplets with more protein-coated, and the network structure was formed only at 80 °C. For the rheological properties, the lower apparent viscosity, elastic index (EI), and macroscopic viscosity index (MVI) in the MPGU group indicated the formation of a more stable emulsion. Furthermore, the lower closed area of Lissajous curves and friction coefficient for the MPGU group also proved the highest stability and lubrication of the emulsion after heat treatment. Therefore, this study indicated that ultrasound-assisted cross-linked myofibrillar protein-stabilized emulsions had good thermal stability and processing adaptability, which contributed to the fabrication of stable emulsion-filled foods.

The use of reduced DOAC doses in atrial fibrillation patients does not always lead to good anticoagulation levels and avoid adverse events

BackgroundThe MAS study (Blood Advances 2024) showed that a high proportion of Italian AF patients treated with direct oral anticoagulants (DOACs) receive reduced doses. This sub-analysis of MAS data aimed to analyze the effects of reduced (appropriate or not)- or standard-dose use on DOAC activity assessed at baseline and the occurrence of thrombotic or bleeding complications during follow-up. MethodsThe MAS study design, the methods for DOAC measurement, the results, and the adverse events during follow-up, are described in detail elsewhere. ResultsSeven hundred AF patients (42 % of the total 1657) received a reduced dose (considered inappropriate in 140 [20 %]). They were older, more frequently women, with lower body mass index (BMI), hemoglobin levels, and creatinine clearance. They more often had cerebral or cardiovascular diseases, were taking more medications, with higher scores for thrombotic or bleeding risk. Despite the use of low doses, 133 (19.0 %) patients had high standardized C-trough DOAC levels and experienced a high proportion of bleeding events (8.3 % per year). Conversely, some patients (4.7 %) had very low levels, resulting in a high incidence of thrombotic events (6.7 % per year). No difference was detected if the reduced dose was appropriate or not. ConclusionThe unpredictable, highly variable inter-individual anticoagulant effect of DOACs may lead to either too low or too high anticoagulant levels, increasing the risk of thrombotic or bleeding events. This is particularly relevant for patients with high-risk conditions, such as those chosen for reduced-dose treatment. Further studies are needed to investigate this important clinical issue.

Field-Aligned Currents during the Strong December 2023 Storm: Local Time and Hemispheric Differences

This study investigates field-aligned currents (FACs) during strong magnetic storms in December 2023, analyzing variations in different local times and in the Northern (NH) and Southern Hemispheres (SH). Peak FAC densities were approximately 7.8 times higher than nominal values, with the most equatorward FACs reaching −52° magnetic latitude (MLat). In the summer hemisphere, the daytime FACs were stronger than the nighttime FACs, with the daytime westward Polar Electrojet (PEJ) surpassing nighttime levels. In the winter hemisphere, the nighttime FACs and westward PEJ were stronger than daytime. Generally, the FACs and westward PEJ were stronger in the SH than in the NH across most local time sectors, attributed to greater solar illumination. The NH pre-midnight currents were stronger than for the SH, indicating enhanced substorm currents during winter nights. The nighttime FACs occurred at lower MLat than daytime, with pre-noon FACs at a higher MLat than post-noon. The NH FACs were positioned more equatorward than their SH counterparts. In the NH, the mean FACs correlated most strongly with the merging electric field (Em) at pre-noon, post-noon, and post-midnight and with the SMU (SuperMAG Electrojet Upper Index) at pre-midnight. In the SH, the mean FACs correlated best with the SMU at pre-midnight/pre-noon, with the SML (SuperMAG Electrojet Lower Index) at post-midnight, and Em at post-noon. The mean MLat of the peak FACs show the strongest correlation with Em across most local times and hemispheres.

The C-reactive protein-albumin-lymphocyte (CALLY) index is a useful predictor of postoperative complications in patients with a colonic stent for obstructive colorectal cancer: a Japanese multicenter study.

The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel score that offers a good reflection of nutritional status, inflammatory response, and immune system status. The CALLY index is reported to correlate with the prognosis of various carcinomas. The purpose of the present study was to investigate the association between the CALLY index and the short-term prognosis of obstructive colorectal cancer managed with a colonic stent. The subjects of this retrospective study were 263 patients who underwent colorectal resection after colonic stenting for obstructive colorectal cancer between 2016 and 2023. Patients were classified into a group with a low CALLY index (CALLY-L group, n = 85) and a group with a high (CALLY-H group, n = 178) CALLY index. The CALLY-L group had greater blood loss (53mL vs 20mL, p = 0.002) and higher poor performance status (PS3; 20% vs 10.1%, p = 0.033), open surgery (21.2% vs 7.3%, p = 0.001), distant metastases (41.2% vs 20.8%, p = 0.01), and postoperative complications (30.6% vs. 18.5%, p = 0.039) than the CALLY-H group. Multivariate analysis identified a prolonged operative time (odds ratio 1.983, 95% confidence interval 1.013-3.881; p = 0.045), greater blood loss (odds ratio 2.572, 95% confidence interval 1.291-5.129; p = 0.007) and a low CALLY index (odds ratio 1.961, 95% confidence interval 1.013-3.795; p = 0.045) as independent predictors of complications. The CALLY index may be a useful predictor of postoperative complications of obstructive colorectal cancer.

The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials.

(1) Background: The Portfolio Diet, a dietary pattern of cholesterol-lowering foods, is also rich in low glycemic index (GI) foods. While strong evidence supports clinically meaningful reductions in cholesterol, evidence on the relationship between the Portfolio Diet and diabetes management is lacking. (2) Objective: To evaluate the relationship between the Portfolio Diet and glycated hemoglobin (HbA1c) as a determinant of glycemic control among adults living with type 2 diabetes mellitus (T2DM). (3) Methods: Patient-level data was pooled from two randomized dietary trials of low glycemic index interventions compared to high cereal fibre control diets in adults living with T2DM where HbA1c was collected (clinicaltrials.gov identifiers: NCT00438698, NCT00438698). Dietary exposure was assessed using weighed 7-day diet records. Adherence to the Portfolio Diet and its pillars (nuts and seeds, plant protein, viscous fibre, plant sterols, monounsaturated fatty acid [MUFA] oils) was determined using the validated clinical Portfolio Diet Score (c-PDS). Multiple linear regression was used to assess the association between change in the c-PDS and change in HbA1c over 6-months with covariate adjustments. (4) Results: A total of 267 participants, predominantly White (67%) and male (63%), were included, with a mean ± standard error age of 62 ± 0.5 years, baseline BMI of 30.2 ± 0.3 kg/m2, HbA1c of 7.08 ± 0.03%, and a c-PDS of 4.1 ± 0.3 points out of 25. Change in the c-PDS was significantly associated with a change in HbA1c (β: -0.04% per point, 95% CI: -0.07, -0.02, p = 0.001). A 7.5-point (30%) increase in the c-PDS was associated with a 0.3% reduction in HbA1c. Of the individual pillars, a 1-point change in nut and seeds intake (β: -0.07%, 95% CI: -0.12, -0.02, p = 0.009) or in plant protein intake (β: -0.11%, 95% CI: -0.18, -0.03, p = 0.009) was associated with a change in HbA1c. Further analysis of plant protein intake revealed that an increase in dietary pulse intake, a particularly low-GI food, was significantly associated with a reduction in HbA1c (β: -0.24% per 1-cup points cooked pulses (226 g) or 2 c-PDS points, 95% CI: -0.45, -0.03, p = 0.028). (5) Conclusions: Among adults living with T2DM, the Portfolio Diet was associated with lower HbA1c over a 6-month period, predominantly driven by two pillars: nuts and seeds and plant protein, particularly dietary pulses. These data have implications for including the Portfolio Diet in dietary recommendations for glycemic control in T2DM. A trial demonstrating the direct causal effect of the Portfolio Diet in a diverse group is warranted.

Magnitude and pace of secular trends of body proportions among young adults with different place of origin, between 2001 and 2019.

The aim of this study was to analyse the occurrence and pace of secular trends regarding body proportions among young adults representing different place of origin, studying in Bydgoszcz (Poland). The data constituted of the results of anthropometric measurements of 1,199 young adults (340 male and 859 female) performed between 2001 and 2019. Selected body build parameters were measured and the following indices were calculated on their basis: upper-limb index, lower-limb index, inter-limb index, chest depth-to-breadth ratio, pelvi-acromial index, reciprocal ponderal index. The place of origin was self-reported by the participants and recorded by the researchers. Based on that piece of information the participants were divided into two categories: villages and small cities, big cities. Considering the pace of the changes, they occurred the fastest for the pelvi-acromial index and the slowest in the case of the lower limb index, which concerned both urbanisation categories. Between 2001-05 and 2016-19 analysed changes generally occurred faster in the high-urbanisation category than in the low-urbanisation one, except for chest depth-to-breadth ratio and lower limb index in male participants as well as reciprocal-ponderal index and pelvi-acromial index among women. In conclusion, obtained results allow observing the changes in selected body proportions occurring over the years 2001-2019 in the population of young adults from Poland. Additionally, the findings can help identify and address risk factors related to specific proportions of the body and present in the contemporary population.

Effects of Microwave Treatment on Physicochemical Attributes, Structural Analysis, and Digestive Characteristics of Pea Starch-Tea Polyphenol Complexes.

Addressing the challenge of blood glucose fluctuations triggered by the ingestion of pea starch, we have adopted an eco-friendly strategy utilizing microwave irradiation to synthesize the novel pea starch-tea polyphenol complexes. These complexes exhibit high swelling capacity and low solubility, and their thermal profile with low gelatinization temperature and enthalpy indicates adaptability to various processing conditions. In vitro digestion studies showed that these complexes have a small amount of rapidly digestible starch and a large amount of resistant starch, leading to a slower digestion rate. These features are particularly advantageous for diabetics, mitigating glycemic excursions. Structurally, the pea starch-tea polyphenol complexes exhibited a B + V-shaped dense network with low crystallinity, high orderliness, and a prominent double helix content, enhancing its stability and functionality in food applications. In summary, these innovative complexes served as a robust platform for developing low glycemic index foods, catering to the nutritional needs of diabetics. It offers an environmentally sustainable approach to food processing, fostering human well-being and propelling innovation in the food industry.

Effects of mulberry leaf enrichment with Lepidium sativum L. seed powder suspension on the economic parameters of Bombyx mori L

The phytochemicals of high nutritional and functional properties in Lepidium sativum L. (garden cress) seeds have nominated their seed powder (regardless of the concentration used) for enrichment of mulberry leaves in order to enhance Bombyx mori L. larval feeding, and consequently to gain ground in sericulture industry. As expected, B. mori larval feeding on L. sativum-enriched mulberry leaves showed not only a remarkable increase in mean values of certain economic parameters of B. mori, such as cocoon weight, cocoon shell weight, pupal weight, and egg yield, compared with the control group, but also showed a phenomenal increase in egg counts (on average, ca. 958–1256 eggs laid per female moth) and a significant increase in egg size (measured as egg surface area and egg volume). Male or female moth larval diet has significantly influenced the reproductive performance or fitness of both sexes of B. mori in terms of large-sized moths (measured as forewing, hind femur, and hind tibia lengths) and highly fecund moths (i.e., increased fecundity and spermatophore counts per female moth, and large-sized eggs). On the basis of B. mori female moth reproductive index, the female moths from L. sativum-fed larvae proved to have a lower reproductive index compared to their corresponding value for females of the control group, indicating more efficient utilization of larval resources for B. mori reproduction. Quantification of the three main physiological resources viz., protein, lipid and carbohydrate in the internal reproductive tract of B. mori female moths at death has nominated the female moth abdomens, or simply their bodies, as being a reasonable natural source of protein, lipid, and carbohydrate, to be involved in certain manufactures (e.g., pet feed formulations) instead of discarding them as a source of environmental pollution. Evidently, the L. sativum seed powder is of considerable interest because it remarkably improves the performance of such an economically important insect, B. mori. This is the first study for evaluating the efficacy of L. sativum seed powder in sericulture field to enhance B. mori productivity parameters.

Failure analysis of a helical compression spring with relatively low spring index

Design of helical springs are well defined and studied thoroughly. Generally, behavior of stiffness is considered to be in linear regime with desired dimensions. However, as the spring index which is defined as ratio of helical diameter to wire diameter gets lower a correction to calculated stress values must be performed. Furthermore, collision between coils, non-homogenous pitch heights between coils, end conditions are other factors leading to increase in stress values as compared to intended design values. An unexpected premature crack formation in a fatigue tested helical compression spring was investigated. First, geometry was measured using CMM and compared with design tolerances. After, metallurgical inspections regarding composition, hardness and microstructure of the material were performed. An analytical and numerical study was conducted in order to evaluate the stress state in the spring. A finite element model was created using ABAQUS and stress increase due to end condition was observed. A premature failure in a helical spring was studied regarding dimensions, material and stress state. The factors leading to nonlinear response of the spring is addressed and compared with experimental tests.

Optimizing the outcome of non-pre-stented flexible ureteroscopic lithotripsy regarding the quality of life, when to remove the stent?

ObjectivesTo investigate the safety of short-term stenting following flexible ureteroscopic lithotripsy (fURL) for patients without preoperative stents. Retaining double-J stent for 1–2 weeks after fURL is a common practice. At present, data on short-term stenting after non-pre-stented fURL is still lacking.Methods182 patients who met inclusion criteria were retrospectively divided into the 2-days group (2-day removal, 76 cases) and the 1-week group (1-week removal, 106 cases). The study endpoint was stent-associated adverse symptoms assessed by follow-up and completed validated questionnaires on postoperative days (POD) 7 and 12. A postoperative imaging review was performed 1 month after the surgery.ResultsNo statistical differences were found in the patients’ demographic and stone-related characteristics. The 2-days group showed fewer urinary tract symptoms and lower scores on the ureteral stent symptom questionnaire on POD 7: less backache during urination (p = 0.004), less hematuria (p = 0.031), less frequent urination (p = 0.004), lower urinary symptoms index (p < 0.001), lower general health index (p < 0.001), and lower performance index (p < 0.001). There were no significant differences in fever (p = 0.372), visual analogue scale score (p = 0.760), and painkiller requirements (p = 0.160) on POD 7. The average general health score and work performance score remained significantly higher in the 1-week group patients at 5 days after removal compared to the 2-days group patients at 5 days after removal. (p < 0.001, p = 0.005). Five patients in the 2-days group and 15 patients in the 1-week group returned to the emergency department for additional treatments. No patient required rehospitalization. Stone-free rates were 85.5% in the 2-days group and 80.2% in the 1-week group (p = 0.499), respectively, and none of the patients got aggravating hydronephrosis.ConclusionsCompared to the common 1-week stent removal option, short-term stenting after non-pre-stented fURL is safe, which can enhance the patient’s quality of life.

Health risk assessment of the concentrations of trace metals in some fruit juices from markets in Ghana

The study aimed to assess the risk exposure of processed fruit juices sold in Ghana by analyzing the concentrations of Cd, As, Ni, Hg, Cr and Pb. 27 processed fruit products were sampled from three markets and categorized based on packaging type. Heavy metals were quantified using Microwave Plasma Atomic Emission Spectroscopy (MPA-ES) The results showed that Cd was not detected in any of the samples, while the average measured concentrations of Ni, Pb, As, Cr and Hg were 0.186, 0.201, 0.299, 0.839 and 0.062 mg/L, respectively. Although Cr levels were within acceptable limits in most products, concentrations of Pb, Hg, As and Ni exceeded permissible levels in several samples. On average, canned products had higher metal concentrations than paper packs and bottles. Imported products also showed higher levels than locally processed items. Pollution assessment indicated low pollution load index below 1. Health risk analysis revealed potential non-carcinogenic risks associated with As, Cr and Hg intake, with a hazard index exceeding 1 in over 50 % of products. Cancer risk estimation showed concerning values for Cr in all samples and Pb in some products. toxic elements could pose health hazards to consumers of processed fruit juices sold on Ghanaian markets.

Perovskite manganese oxide-based superposed multilayer film with high emittance tunability for smart radiation devices

Smart radiation devices (SRDs) with the ability to switch emittance according to the radiator surface’s temperature are significant for spacecraft thermal control on exploration missions with drastic changes in thermal environments. However, it is quite urgent to improve the performance of the intelligent thermal control films in SRDs due to the limitations such as low emittance tunability and inappropriate phase transition temperature. Consequently, a film with self-adaptive infrared emittance based on anti-reflective design is proposed in this paper. The main structure is a superposed multilayer film based on a doped perovskite manganese oxide La0.825Sr0.175MnO3 (LSMO) and BaF2 stacks. The emittances of the designed multilayer film are 0.18 and 0.83 at the temperatures of 100 K and 295 K, and therefore the emittance tunability achieves 0.65. Compared with single-layer LSMO, the emittance tunability has increased 25 % approximately. The enhancement in emittance tunability can be explained by the fact that multilayer films with staggered low and high refractive index dielectric layers may cause destructive interference and suppress the Fresnel reflections at high temperatures. In addition, the thickness of dielectric part is carefully designed to avoid the formation of high emissivity Fabry-Perot (FP) resonance when LSMO switches to metallic state at low temperatures. This perovskite manganese oxide-based multilayer film exhibits remarkable intelligent thermal control properties. It provides a significant opportunity to improve the performance of SRDs and a promising potential for maintaining the optimal operating temperature of the spacecraft.

ECG changes following balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a retrospective study

PurposeThis research evaluates the effect of balloon pulmonary angioplasty (BPA) on cardiac electrophysiological changes in patients with chronic thromboembolic pulmonary hypertension (CTEPH).MethodsInvolving a retrospective analysis of 39 CTEPH patients (average age 61 ± 11), who had at least two BPAs and paired ECGs pre- and post-surgery, we examined changes in ECG indicators of right ventricular hypertrophy and their correlation with hemodynamic results.Results BPA yielded marked improvements in cardiac function and hemodynamics. ECG parameters, specifically the Lewis criteria and Butler-Leggett score, correlated strongly with hemodynamics and were predictive of a mean pulmonary arterial pressure (mPAP) ≥ 35mmHg. Notably, QRS complex axis normalization was observed in 25 patients, with 14 fully normalizing (range − 30° to + 90°). The qR pattern in V1 vanished in 9 cases, and 75% of the patients in qR pattern in V1 group had QRS complex electrical axis completely returned to normal range. The qR V1 group had higher mPAP and pulmonary vascular resistance (PVR), and lower cardiac output and index compared to the non-qR V1 group, alongside a higher Butler-Leggett score.ConclusionsBPA enhances cardiac function and hemodynamics in CTEPH patients, with certain ECG measures such as Lewis criteria and Butler-Leggett score reflecting the severity of hemodynamic impairment. The reversal of QRS axis deviation and the disappearance of the qR pattern in lead V1 may serve as valuable indicators for assessing post-BPA satisfaction in CTEPH patients.

Singlestick purchases: a comparative cross-country analysis in 10 African countries, Global Adult Tobacco Survey, 2012-21.

We utilized Global Adult Tobacco Survey data to examine singlestick purchases and related demographic characteristics in 10 African countries (Botswana, Cameroon, Ethiopia, Kenya, Nigeria, Mauritania, Senegal, South Africa, Uganda and Tanzania). Results show the weighted percentages and prevalence ratios with predicted marginal means to evaluate significant differences between groups (P < 0.05). The prevalence of singlestick purchases among the 10 African countries ranged from 48.4% in South Africa to 92.0% in Tanzania. Across countries, the incidence of singlestick purchases was higher in urban areas than rural areas in Kenya; among those aged 15-24 years versus those aged 45 years and older in Botswana, Ethiopia, Mauritania, Nigeria and South Africa; and among those aged 25-44 years versus those aged 45 years and older in Botswana, South Africa and Tanzania. The incidence in Botswana was higher among adults with no formal or primary education than among those with secondary or higher education. In South Africa, the incidence was higher among adults in the middle or lower wealth index than among those in the high or highest wealth index. The findings suggest opportunities for strengthening efforts to prevent singlestick purchases through effective legislation and enforcement in line with Article 16 of the World Health Organization Framework Convention on Tobacco Control.

A novel x-Ray and γ-Ray combination strategy for radiotherapy after breast-conserving surgery in patients with right breast cancer.

Radiotherapy is a primary therapeutic approach for breast cancer following breast-conserving surgery. The TaiChiB dual-modality radiotherapy system combining X-ray and focused γ-ray, offers a new approach to reduce the radiation dose of organs at risk (OARs) and has the potential to mitigate the adverse effects of radiotherapy. Currently, there are few studies on the dosimetric characteristics of the TaiChiB dual-modality system for actual treatment plans for specific diseases. The purpose of this work is to study the dosimetric advantages of dual-modal systems for right breast patients after breast-conserving surgery. Treatment plans for 20 patients with right breast cancer were generated for a linear accelerator (LINAC) based system and the TaiChiB dual-modality system, respectively. Volumetric modulated arc therapy plans with simultaneous integrated boost (VMAT-SIB) were made for the LINAC. Focused γ-ray was used to deliver the boost dose with the dual-modality system. The dosimetric parameters of the target and OARs were evaluated and compared between the treatment plans generated for the two systems. The TaiChiB dual-modality plans exhibit a higher conformal index (CI) and lower gradient index (GI) for the PGTV and PTV compared with the LINAC-based VMAT-SIB plans. Compared to VMAT-SIB plans, the PTV Dmax, PTV Dmean, PTV V110, PGTV Dmax, and PGTV Dmean of the TaiChiB dual-modality plans are significantly lower. Meanwhile, the dose to OARs, such as the Dmean of the heart, the V5 of liver, the Dmean of ipsilateral lung, the V30 of ipsilateral lung, the V20 of ipsilateral lung, the V5 of ipsilateral lung, the Dmean of contralateral lung, Dmax of contralateral breast and the Dmean of contralateral breast are significantly reduced. Our study demonstrates the dosimetric advantages of the novel TaiChiB dual-modality radiotherapy system for the treatment of right-sided breast cancer. Overall, for the TaiChiB dual-modality radiotherapy system, the radiation dose outside the target region decreases rapidly, thereby minimizing radiation exposure to neighboring organs and ensuring the conformity of the target area. Our research confirms the potential of the TaiChiB dual-modality system for future radiotherapy.

Utilizing kraft lignin–derived hard carbon as an innovative bio-electrode in electrochemical capacitors

AbstractIn recent years, biomaterials are gaining popularity due to high need to make energy storage devices greener and safer. After the carbonization process, lignin has a slightly larger specific surface and a porous structure, which can provide a significant electrochemical double-layer capacity. When combined with kraft lignin as a binder, which helps maintain the structural integrity of the electrode, the efficient use of the active material can be enhanced. The binder facilitates better dispersion of carbonized lignin particles, reducing agglomeration and ensuring greater availability of active sites for electrolyte ions. The aim of this work is to present a novel lignin-based hard carbon as an electrode material for applications in electrochemical capacitors. To this end, a detailed physicochemical and electrochemical analysis was conducted. Kraft lignin was carbonized at temperatures ranging from 600 to 1000 °C. The resulting material is characterized by thermal stability, a low polydispersion index (PDI), and mesoporosity. Thermogravimetric (TG) analysis was used to determine changes in structure, while functional groups were analyzed using Fourier-transform infrared spectroscopy (FTIR). In electrochemical applications, the material exhibits high cyclic stability and no redox reactions, with the primary mechanism of charge accumulation being based on the electrochemical double layer. Additionally, low resistances contribute to improved charge storage. Graphical abstract