SESSION TITLE: Respiratory Failure SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, November 1, 2017 at 01:30 PM - 02:30 PM PURPOSE: Mechanically ventilated acute respiratory failure patients have low levels of activity, which contribute to muscle weakness and functional impairment. Limited data exists on the quantification of activity in critically ill patients as they transition from the intensive care unit to the wards and subsequently, back into the community. This study aims to characterize the physical activity of critically ill patients from the intensive care unit until seven days after discharge from hospital. METHODS: We recruited previously independent adult patients age 55 or older, undergoing mechanical ventilation for seven days or less via endotracheal tube or mask, who had begun spontaneous breathing trials or been extubated within the prior 24 hours. Patients received an accelerometer (Tractivity®, Kineteks Corporation, British Columbia, Canada) at the time of enrollment that was to be worn on their ankle until one week after discharge. Participants were asked to mail them back to the study team. The Short Physical Performance Battery (SPPB), an objective physical function measurement designed for low-functioning individuals was measured at ICU and hospital discharge. Means and medians were calculated for patient demographics, SPPB, as well as number of steps for three days prior to ICU discharge, three days prior to hospital discharge and subsequently for days 1-3 and days 4-6 after hospital discharge. Paired student t-tests were used to compare activity levels before and after hospital discharge. Clinicaltrials.gov number NCT02293616. RESULTS: A total of 22 subjects received Tractivity accelerometers; 16 were returned and available for analysis. One patient was excluded as only two days of data was available. Of the 15 study subjects, 47% were female, with an average age of 68±9.6 years and BMI of 30.7±6. The subjects spent a median (IQR) of 3 (2-4) days in the ICU and 7 (6-13) days in the hospital. They were intubated for 2 (1-3) days total. Mean SPPB scores at ICU discharge (0.8±1.3) and hospital discharge (1.9±1.9) were available for 14 patients. Step counts (median (IQR)) were 64 (42-125) in the 3 days prior to ICU discharge, 142 (71-390) in the three days prior to hospital discharge, 788 (133-2195) in the first three days at home and 1104 (81-2527) between days 4-6 post-hospital discharge. Patients had significantly increased physical activity during days 1-3 post-discharge (p=0.04) and days 4-6 after hospital discharge (p=0.03) as compared to before hospital discharge. CONCLUSIONS: Subjects’ physical activity increased as they transitioned from the ICU to the hospital wards, but had a substantial rise as they returned to the community. Despite having very poor SPPB scores at both ICU and hospital discharge, subjects were significantly more active immediately after discharge than in their last three days of hospitalization. This may represent rapid functional improvement or conversely, constrained physical activity in the hospital. CLINICAL IMPLICATIONS: Critically ill patients have limited mobility after their critical illness. Quanitification of physical mobility for critically ill patients during their inpatient and post-discharge course allows for recognition of their limitations and development of interventions to improve functional recovery. DISCLOSURE: The following authors have nothing to disclose: Sheetal Gandotra, Rita Bakhru, Katherine Shields, Michael Berry, Daniel Files No Product/Research Disclosure Information