The geologic conditions in the western part of the Chalkidiki Peninsula are favourable for the formation, reproduction and accumulation of six to seven types of mineral waters, and of considerable resources of low-enthalpy geothermal energy and endogeneous CO2. Low-mineralized thermal waters with nitrogen gas composition and comparatively low (25-45°C) temperatures form small accumulations related to fault structures in ophiolitic bodies and metamorphic rocks in the NW of the peninsula. Within the other, bigger part of the peninsula, deposits and regional reservoirs of carbonated (saturated in endogenous CO2) mineral waters with bicarbonate (HCO3), bicarbonate-chloride (HCO3-Cl) or chloride (Cl) composition have been formed. The total mineralisation of these waters increase from 2-5 to 30-40 g/l in function of the depth of the reservoirs, and the temperature increase is from 20-30° to 80-90°, correspondingly. The principal reservoir of carbonated mineral waters and geothermal resources is a considerably tectonised formation of Upper Jurassic limestones which has been buried under Neogene marine sediments at depth from 200-300 to 2000-3000 m. The study and prospects for development of Chalkidiki centers of multiseasonal and curative tourism and a parallel industrial exploitation of geothermal energy and natural CO2.