Objective: The appropriateness of the current neuropsychological tests for the assessment of different populations has been questioned. In this issue several articles have proposed the modernization of neuropsychological testing by incorporating modern technological devices such as computers, mobile phones, or tablets. This is a commentary on the articles contained in the special issue about the inclusion of modern assessment methods that can be properly used around the world and not only in technologically/economically advanced countries.Methods: The author of this article reviewed the articles included in the special issue with the goal of commenting on whether the new approaches proposed would have global relevance and applicability.Results: The use of biomedical databases and modern technological devices such as computers, wearables and tablets might not be available in many countries, thus leading to a situation in which modern neuropsychological tests might be available only in some world regions. In addition, because in many countries there are large percentages of population with low education these modern neuropsychological tests might not be appropriate for them. Finally, tests developed with culturally specific stimuli will not be applicable in some cultures.Conclusion: This article provides an overview of several issues that should be considered to make neuropsychological tests both modern and accessible around the world, more specifically the cross-cultural appropriateness and accessibility for low educated individuals and availability in low/middle income regions.