Low Coverage Research Articles

Green space-building integration for Urban Heat Island mitigation: Insights from Beijing's fifth ring road district

In this research, we delve into the complex arrangement of urban landscapes, where green spaces and buildings are not merely co-existing but are interwoven into a cohesive fabric that shapes the thermal environment. Our approach transcends the conventional methods of analysis, which typically isolate the roles of greenery or built environments. Instead, we adopt a synergistic perspective that recognizes the collective influence of these landscape constituents on the urban thermal pattern. Key insights are: (1) A linear decrease in average land surface temperature with increasing green space coverage is observed. However, substantial temperature variations (up to 8 °C) within the same coverage interval highlight the significant impact of built-up pattern on thermal conditions; (2) High Building Height and Floor Area Ratio, and low Building Coverage Ratio and Sky View Factor, are linked to cooler temperatures in areas with up to 50 % green space; (3) The study suggests that low-temperature areas can inform the adjustment of built-up patterns in high-temperature areas, offering a strategy for thermal environment optimization within specific green space coverage intervals. This research contributes insights into the integrated planning of green spaces and buildings, with implications for urban development and renewal initiatives aiming to enhance the urban thermal environment.

Effect of a participatory whole-systems approach on mortality in children younger than 5 years in Jigawa state, Nigeria (INSPIRING trial): a community-based, parallel-arm, pragmatic, cluster randomised controlled trial and concurrent mixed-methods process evaluation

In 2019, Nigeria reported the highest mortality rate in children younger than 5 years globally. We aimed to assess a whole-systems approach to improving child mortality in northern Nigeria. We conducted a community-based, parallel-arm, pragmatic, cluster randomised controlled trial in Kiyawa local government area, Jigawa state, Nigeria, and a concurrent mixed-methods process evaluation using ethnography and quantitative implementation monitoring. Trial clusters were population catchment areas of 32 government primary health-care facilities. Compounds were randomly sampled, proportional to cluster size, and all women aged 16-49 years and children younger than 5 years who were permanent residents were eligible for inclusion and recruited as the evaluation population. Children younger than 7 days were recruited but excluded from analysis. Evaluation clusters were allocated to intervention or control via simple randomisation with a 1:1 ratio. Cluster names were written on paper, folded, and placed in a container by community representatives. Different community representatives took out names one by one, with the first half assigned to receive the intervention. The intervention consisted of three components: participatory learning and action (PLA) groups for men and women (including compound heads [ie, the member of the compound that residents deemed most senior]), partnership defined quality scorecard (PDQS), and health-care worker capacity building; it was delivered from March 1, 2021, to Dec 31, 2022. We could not mask participants, field staff, or intervention-delivery staff to cluster allocation but baseline, endline, and follow-up data excluded information on cluster allocation. PLA groups involved separate groups of up to 25 men or women from all villages in the intervention clusters. The primary outcome was all-cause mortality in children aged 7 days to 59 months between Oct 1, 2021, and Sept 20, 2022, referred to as the evaluation period. The trial was prospectively registered (ISRCTN 39213655) and the protocol has been published. We recruited 3800 compounds at baseline, with 12 893 children contributing to analysis of the primary outcome (7316 [56·8%] of 12 893 in the intervention group and 5577 [43·3%] in the control group). 6617 (51·3%) of 12 893 children were male, 6275 (48·7%) were female, and one (<0·1%) child had missing sex data. Sampled compounds randomly came from 388 (91·3%) of 425 villages in the 32 clusters. We conducted verbal autopsies for 1182 deaths, of which 369 (31·2%) were children aged 7 days to 59 months during the evaluation period. Of these 369, 91 (24·7%) were classified as pneumonia deaths. Children contributed a median 361 days (IQR 236-365) to the analysis, with 369 (2·9%) of 12 893 children censored on their date of death, 1545 (12·0%) on their 5th birthday, and 3392 (26·3%) on the date of the most recent follow-up in which their residence or survival status was known. We found no significant decrease in all-cause mortality (hazard ratio 0·95, 95% CI 0·68-1·33; p=0·79) or suspected pneumonia mortality (0·79, 0·43-1·46; p=0·46) in the intervention group. The process evaluation showed low coverage and issues in reach of the intervention, but qualitative data highlighted mechanisms for positive effects on health and relationships. Our intervention did not affect mortality. However, due to the high child mortality in this region, further efforts should be made to adapt our participatory whole-systems approach to use communities of action within compounds. GSK and Save the Children UK. For the Hausa translation of the abstract see Supplementary Materials section.

Identifying measures for understanding and addressing county-level disparities in adolescent HPV vaccination coverage in North Carolina.

HPV vaccination coverage is characterized by geographic disparities in the US, with national studies finding lower coverage in rural versus nonrural areas. To direct quality improvement efforts in North Carolina, we sought to understand how different rurality measures characterize these disparities. We used separate negative binomial regression models to test associations between 5 dichotomized county-level rurality measures and HPV vaccination coverage (≥1 dose) among North Carolina adolescents, ages 11-12 (n=326,345). Rurality measures were derived from: Office of Management and Budget's Metropolitan Statistical Areas, Rural-Urban Continuum Codes, Index of Relative Rurality, US Census Bureau classifications, and North Carolina Rural Center classifications. Models controlled for Social Vulnerability Index (SVI) percentile and rate of pediatricians per county. Vaccination data came from the North Carolina Immunization Registry. HPV vaccination coverage was 29% across North Carolina's 100 counties (range: 13%, 46%). Agreement between rurality measures ranged from 54% to 93% of counties. In adjusted analyses, none of the 5 rurality measures correlated with HPV vaccination coverage, but higher SVI and higher rate of pediatricians were positively associated with coverage (p< 0.01). Exploratory moderation analyses suggested regional variation in the relationship between rurality and coverage, with a positive association in one region, a negative association in one region, and no association in four regions. County-level rurality measures did not identify disparities in HPV vaccination coverage in North Carolina. Measures related to social vulnerability and access to pediatricians may be better suited for understanding and addressing the state's substantial county-level vaccination disparities.

A novel flexural damping channel magnetorheological damper with high effective magnetic field coverage and experimental verification of damping performance

Abstract Conventional magnetorheological dampers (MRDs) have limitations owing to their low effective magnetic field coverage, and improving MRD structures is a common approach to address this issue. However, many existing MRD designs have limitations such as large radial dimensions and high coil power consumption. Therefore, this paper transformed the conventional damping channel into the flexural damping channel to increase the effective magnetic field coverage of the MRD based on the conventionalstructure. And then, the pressure drop model was utilized to preliminarily determine the structural parameters of the new MRD. Subsequently, a multi-physics coupling finite element method (FEM) analysis model was constructed to accurately determine the structural parameters, ensuring that the novel flexural damping channel (NFDC) MRD increases the output peak damping force while reducing the radial dimension and input power. Furthermore, the damping force variable range is stabilized when the excitation current is zero (field-off). Finally, a large number of vibration tests were conducted on both the conventional and NFDC MRDs, and it was found that the NFDC MRD has better vibration energy dissipation capacity and higher output peak damping force while maintaining a basically same field-off damping force variable range compared with the conventional MRD. The above process not only proved that the NFDC MRD possesses excellent output damping capability and working condition adaptability, but also validated the operational effectiveness of employing the multi-physics coupling analysis method to design the NFDC MRD.&amp;#xD;

Epidemic Situation in Osh, Kyrgyz Republic on Infections Controlled by Specific Prevention Means and Analysis of Population Awareness on Measles Infection

The article reflects a long-term (2009-2023) retrospective epidemiological analysis of measles incidence among the population in Osh, characterized by a periodic increase in incidence every two to three years and a decline after the adopted response measures to outbreaks, such as additional mass immunization of vulnerable groups of the population. However, the increase in measles incidence that began in 2018 continued for three years (2018-2020). Also, the increase in measles incidence, which began in the spring-summer period in 2023, despite the organization of preventive and anti-epidemic measures, continues in 2024, starting from the winter-spring period. This study revealed low vaccination coverage of children in the period from 2019 to 2023 at the level of 85.0-95.0%, which is associated with various reasons (underage, medical exemptions, parental refusal to vaccinate, population migration and unknown vaccination status, etc.).

Removal of cefuroxime from aqueous solution by biochars derived from antibiotic mycelial residue.

In China, antibiotic mycelial residue is categorized as hazardous waste. To achieve the harmless and resourceful disposal of cephalosporin, three types of biochars from cephalosporin mycelia residues, namely non-activated carbon (BC1), ZnCl2-activated carbon (BC2), and KOH-activated carbon (BC3), were respectively fabricated by high-temperature pyrolysis carbonization technology. These three kinds of biochars were characterized via iodine value, FTIR, and SEM, and the adsorption performance of the prepared biochars was investigated using cefuroxime (CXM) as the adsorption target. The results indicated that BC3 biochar possesses the most well-developed pores and the highest iodine value of 1367.41 mg/g; The most suitable dosage is 1.6 g/L, and the lower the pH, the more favorable the adsorption effect. The investigation of adsorption kinetics revealed that it conformed to the kinetic model of pseudo-second order, as well as the process of adsorption was governed by the chemical adsorption mechanism, the rate of adsorption was affected by the collective impact of the quantity of active sites present and the interaction strength between the CXM molecules and the biochar. The exploration of adsorption thermodynamics revealed that it aligned with the Langmuir model, the surface of biochar was relatively uniform, and the adsorption was mainly of low coverage; The calculation of thermodynamic parameters demonstrated that the adsorption was exothermic and spontaneous.

Probing Surface-Mediated Electronic Coupling in Flat Hexagonal Phosphorus Nanostructures and Monolayer on Au(111).

Due to its diverse allotropes and intriguing properties, 2D phosphorus, also known as phosphorene, is a material of great interest. Here, the successful growth of flat hexagonal 2D phosphorus on Au(111) is reported. Starting from phosphorus linear chains at low coverage, a porous network and finally an extended 2D flat hexagonal (HexP) layer while increasing phosphorus deposition is formed. Using scanning tunneling microscopy/spectroscopy combined with ab initio calculations, the structure and electronic properties of the as-grown phosphorus structures are followed. The progressive formation of a phosphorus electronic band in the conduction band region is followed. More strikingly, a partial flatband that appears only on the HexP phase characterized by a sharp peak in the electronic spectrum is observed. These bands arise from the hybridization of phosphorus and gold atoms. This novel phosphorus-based structure exhibits remarkable electronic properties due to gold mediated phosphorus-phosphorus electronic coupling. This work paves the way for new interface material developments with attractive electronicproperties.

Cas9-targeted-based long-read sequencing for genetic screening of RPE65 locus.

Long-read sequencing (LRS) enables accurate structural variant detection and variant phasing. When a molecular diagnosis is suspected, target enrichment can reduce the cost and duration of sequencing. LRS was conducted in five inherited retinal dystrophy (IRD) patients harboring a monoallelic variant in RPE65 that remained uncharacterized after clinical exome sequencing (CES). CRISPR-Cas9 guide RNA probes were designed to target a 31kb region, including the entire RPE65 locus. The DNA was sequenced on a MinION platform. Short-read ×30 whole-genome sequencing (WGS) was performed for five patients to validate nanopore results. The nanopore sequencing process yielded a median of 271 reads within the targeted region, with a mean depth of 109 and a median read size of 8kb. All variants identified by CES have been detected using this approach, and no additional RPE65 gene causative variants were found. Nanopore variant detection demonstrated performance akin to short-read WGS at similar coverage levels, although exhibiting increased false positive calls at lower coverage. In this study, we explore the advantages of using a targeted approach together with long-read sequencing to identify variants associated with IRD. The results underscore the utility of targeted long reads for characterizing patients affected by rare diseases when first-tier diagnostic tests are non-conclusive.

Turmeric Topical Application: An effective solution for reducing breast milk secretion delays in new mothers

Background: The problem of low coverage of exclusive breastfeeding is partly influenced by insufficient breast milk production. The percentage of exclusive breastfeeding in infants under six months of age in Central Kalimantan in 2020 was 52.98%. This percentage was among the lowest nationally. In 2021, the coverage of exclusive breastfeeding in infants under six months of age reached 56.8%, and in 2022 it did 60.5%. The figure in 2022 exceeded the set target, but several regencies/cities still had low coverage. Insufficient breast milk supply impacts on the nutritional status of the child. Low breast milk production also arises due to several other factors during breastfeeding, namely late initiation of breastfeeding, long breastfeeding time, sore nipples, breast pain and swelling, and inverted nipples. Aims: The study sought to measure the level of success of turmeric topical application in shortening the time it takes to initiate breast milk secretion. Methods: The study uses a true experimental posttest-only control group design. A subject of 50 mothers having full-term spontaneous deliveries and with normal breasts was used in the study. The sample was divided into two groups: control and intervention groups. The sample was selected using a matching process based on age, parity, and early initiation of breastfeeding. Subjects who met the inclusion criteria were offered whether they were willing to be given turmeric compresses after the delivery process. Subjects who were willing were included in the intervention group and those who were not willing were included in the control group. Age and parity in the intervention group were all taken, while the control group was selected to match the intervention group. The intervention group was given a treatment with a turmeric compress on the breasts for six hours. All participants were then observed for time of breast milk secretion initiation. In this experiment, we didn't perform blinding, but we managed it by having the midwife administer the turmeric compress just once during the delivery process before sending the client home. Following this, we recorded the results, specifically the initial breast milk release in both the intervention and the control group. Results: The average time periods it took to initiate breast milk secretion in the intervention and control groups were 509.96 minutes (8.5 hours) and 1573.76 minutes (26.2 hours), respectively. There was a significant difference (p = 0.023) in the time of breast milk secretion initiation of 1063.8 minutes or 17.73 hours between both groups. Conclusion: Applying a turmeric compress on the breasts of postpartum mothers may shorten the time it takes to initiate breast milk secretion. Received: 05 August 2024, Reviewed: 23 August 2024, Revised: 21 September 2024, Accepted: 13 October 2024.

Impact of vegetation coverage and configuration on urban temperatures: a comparative study of 31 provincial capital cities in China

Urban vegetation plays a crucial role in regulating temperatures and heat waves in urban areas. However, the influence of vegetation coverage and its configuration on surface temperatures in different climate zones at a national scale is unclear. To address this, we utilized high-resolution data to detect spatial patterns for 31 provincial capital cities in China. We integrated day and night surface temperatures to determine the influence of vegetative coverage and configuration on urban temperatures across different climate zones and city sizes. Our study revealed that a subtropical monsoon climate and medium-sized cities had the highest vegetative coverage and shape complexity. The best connectivity and agglomeration of vegetation were found in a temperate monsoon climate and large cities. In contrast, small cities, especially those under a temperate continental climate, had low vegetation coverage, high fragmentation, and weak agglomeration and connectivity. In addition, vegetative coverage had a negative impact on daytime surface temperatures, especially in large cities in a subtropical monsoon climate. However, an increase in vegetation coverage could result in warming at night in small cities in temperate continental climates. Although urban vegetation configuration also contributed to moderating surface temperatures, especially at night, they did not surpass the influence of vegetation coverage. The effect on nighttime temperatures of the configuration of vegetation increased by 3–6% relative to that of daytime temperatures, especially in large cities in a temperate monsoon climate. The contribution vegetation coverage and configuration interaction to cooling efficiency decreased at night, especially in medium-sized cities in a temperate continental climate by 3–5%. In addition, this study identified several moderating effects of natural and social factors on the relationship between urban vegetation coverage and surface temperatures. High duration of sunshine, low humidity and high wind speed significantly enhanced the negative impact of vegetation coverage on surface temperatures. In addition, the moderating effect of vegetation coverage was more pronounced in low population density cities and high gross domestic product. This study enhances understanding of the ecological functions of urban vegetation and provides a valuable scientific basis and strategic recommendations for optimizing urban vegetation and improving urban environmental quality.

Optimization Strategies of Phase Change Materials Applied in Fruit Cold Chain: Apples Transportation of Freshippo

The current fruit cold chain in China faces problems such as low coverage of cold chain services, high turnover losses, and waste of resources. It has been found that novel temperature control technologies using phase change materials (PCM) can be applied to fruit cold chains but have not yet been widely adopted. This study attempts to predict the effectiveness of PCM in the two main stages of cold chain storage and transport based on real case scenarios. By assessing the economic, environmental, and social benefits achieved, this study examines whether PCM has practical value in optimizing the fruit cold chain for sustainable development. In this more detailed version, the study delves into the application of PCM technology in the fruit cold chain and its economic, environmental and social impacts. It presents additional case studies and theoretical discussions to provide more in-depth thinking and guidance for the sustainable development of the cold chain industry.

Determinants of Low Coverage of the Free Surgical Care Programme for Trachomatous Trichiasis in Rural Guinea in 2022.

This study aimed to describe the experiences of healthcare personnel and patients in the organization of free surgical campaigns and care for trachomatous trichiasis in the health district of Siguiri in Guinea, including challenges experienced in providing surgical care. This was an explanatory qualitative study conducted in 2022 in the health district of Siguiri. A total of 20 participants were interviewed including patients (n = 7; 35%), community health workers (n = 4; 20%), health services managers, and healthcare providers (n = 8; 40%). Two main data collection technics were used: documentary review and in-depth individual interviews. All interviews were transcribed and manually coded using an Excel extraction spreadsheet. Data were analysed using inductive and deductive approaches. The results showed several organizational, structural, and community challenges that underlined the low surgical coverage of trachomatous trichiasis in the health district of Siguiri. Organizational challenges included the low involvement of local actors in planning activities, the limited timeframe of the campaigns, and the lack of logistics for activities supervision and patients' transportation to surgery sites. Structural challenges included the inadequacy of health centres to provide surgical services, poor health infrastructures, and sanitation conditions in some areas. Individual challenges included remoteness of surgical sites and costs associated with services provision including medicines. Community challenges included fear of surgery and the coincidence of the campaigns with agricultural and mining activities. The results of the study call on the national neglected tropical disease program and its partners to adopt and promote micro-planning of trachomatous trichiasis surgical activities, with the effective participation of local stakeholders in endemic health districts. They should also envision integrating the management of surgical treatment including costs associated with care (transportation, food, rehabilitation support for patients who have undergone surgery) and complications of surgical procedures for an expansion of the trachomatous trichiasis free surgical care coverage in endemic health districts in Guinea.

Vegetation Growth and Physiological Adaptation of Pioneer Plants on Mobile Sand Dunes

The Hunshandake Sandy Land is one of the largest sandy areas in China and the closest source of sand dust to the Beijing and Tianjing areas. Sand fixation by vegetation is considered the most efficient strategy for sand control and sustainable development, so clarifying the vegetation coverage and plant adaptation characteristics in the Hunshandake Sandy Land is helpful in guiding restoration and improving local sustainability. Here, we investigated the vegetation growth on the mobile sand dunes in the Hunshandake Sandy Land and specified the photosynthesis and stomatal characteristics of the pioneer plants for sand fixation. The vegetation survey showed that the windward slopes of the mobile sand dunes had far lower plant coverage (6.3%) and plant biodiversity (two species m−2) than the leeward ones (41.0% and eight species m−2, respectively). Elymus sibiricus L. and Agriophyllum squarrosum (L.) Moq. were the only two sand-fixing pioneer plants that grew on both the windward and leeward slopes of the mobile sand dunes and had higher plant heights, greater abundance, and more biomass than other plants. Physiological measurements revealed that Elymus sibiricus L. and Agriophyllum squarrosum (L.) Moq. also had higher photosynthetic rates, transpiration rates, and water use efficiency. In addition, the stomata density (151–197 number mm−2), length (18–29 μm), and area index (13–19%) of these two pioneer species were smaller than those of the common grassland species in Inner Mongolia, suggesting that they were better adapted to the dry habitat of the mobile sand dunes. These findings not only help in understanding the adaptive strategies of pioneer plants on mobile sand dunes, but also provide practical guidance for sand dune restoration and the sustainable development of local areas. Pioneer sand-fixing plant species that are well adapted to sand dunes can be used for sowing or aerial seeding in sand fixation during ecosystem restoration.

Structure, orientation, and dynamics of per- and polyfluoroalkyl substance (PFAS) surfactants at the air-water interface: Molecular-level insights

HypothesisUnderstanding the intricate molecular-level details of toxic per- and polyfluoroalkyl substances (PFAS) partitioning to the air–water interface holds paramount importance in evaluating their fate and transport, as well as for finding safer alternatives for various applications, including aqueous film forming foams. The behavior of these substances at interfaces strongly depends on molecular architecture, chemistry, and concentration, which define molecular packing, self-assembly, interfacial diffusion, and the surface tension. SimulationsModeling of three PFAS surfactants, namely, longer-tail (perfluorooctanoate (PFOA)) and shorter-tail (perfluorobutanoate (PFBA) and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy) propanoate (GenX)) has been conducted using atomistic molecular dynamics simulations. A systematic comparison between these representative PFAS of different sizes and structure reveals factors influencing their association behavior, mechanism of surface tension reduction, and interfacial mobility as a function of surface coverage. FindingsShorter-chain PFAS surfactants (GenX or PFBA) require lower surface coverage compared to longer chain (PFOA) PFAS to achieve the same decrease in surface tension. However, a higher concentration of GenX and PFBA is necessary in the bulk aqueous solution to achieve the same surface coverage as PFOA, due to their higher solubility in water. The PFAS molecular orientation and mobility at the interface are found to be vastly influenced by the length and architecture of the hydrophobic fluorocarbon tail. A significant ordering of the water dipole moment near the anionic headgroup is apparent at high surface concentration. A direct correlation is established between the PFAS interfacial properties and PFAS-PFAS, PFAS-counterion, and PFAS-water interactions.

A single-feed circularly polarized antenna with a low vertical profile and hemispherical axial-ratio beam coverage

ABSTRACT A novel wide axial-ratio beamwidth (ARBW) circularly polarized (CP) antenna with a single layer substrate fed by a single probe is proposed. It consists of an inner annular slotted radiator containing eight outer sector units with arc branches, a ground plane, and eight grounded vias. The antenna has an ARBW covering the upper hemisphere and has a low vertical profile. The ultra-hemispherical ARBW is formed by ingeniously merging the endfire omnidirectional CP radiation pattern with the boresight CP radiation pattern. The two radiation patterns can be excited by a central coaxial probe without an additional feeding network. An antenna prototype of dimensions 1.15 × 1.15 × 0.02 (λ 0 3) is fabricated and measured to validate the design concept. Measured results show that the impedance bandwidth of the proposed antenna is 2.0% (3.328–3.394 GHz) and the 3 dB axial ratio (AR) bandwidth is 1.3% (3.332–3.374 GHz). The 3 dB AR beamwidth can cover more than 217° and the maximum gain is 0.79 dBic at 3.35 GHz. A good agreement between the simulated and measured results is obtained.

Habitat area more consistently affects seagrass faunal communities than fragmentation per se

AbstractSeminal ecological theories, island biogeography and the single large or several small (SLOSS) reserve debate, examine whether large contiguous habitats conserve biodiversity better than multiple smaller patches. Today, delineating the ecological effects of habitat area versus configuration in a fragmentation context remains difficult, and often confounds efforts to understand proximate and ultimate drivers of community change in response to habitat alteration. We examined how the major components of fragmentation, habitat division versus area loss, independently influence faunal communities using landscapes constructed from artificial seagrass at scales relevant for juvenile estuarine nekton. We deployed 25 unique, 234‐m2 landscapes designed along orthogonal axes: habitat percent cover (i.e., area) and fragmentation per se (i.e., patchiness) to examine their effects on faunal density, community composition, and probability of bait‐assay consumption. Faunal sampling occurred in both artificial seagrass and interspaced sandflat matrix. We also examined whether larval‐settler density drove faunal density patterns across landscapes. Further, we assessed the relative importance of landscape‐scale parameters versus fine‐scale complexity–canopy height and epiphyte biomass–in determining faunal densities. We most consistently observed increasing epibenthic fish and macroinvertebrate density with increasing seagrass percent cover. Fragmentation per se only negatively affected epibenthic faunal density within the matrix at low seagrass coverage. Bait consumption increased with seagrass cover, suggesting larger habitats are relative foraging hotspots. Alternatively, benthopelagic fish density was unaffected by habitat parameters, reflecting lower seagrass reliance, or increased matrix tolerance. Community compositions did not vary across landscapes, suggesting that abundant species used landscapes indiscriminately. Finally, the relative importance of habitat parameters shifted across faunal guilds and life stages. Landscape percent cover most affected epibenthic faunal density, but not benthopelagic fish density, and neither pattern was related to settler density. Further, only fine‐scale complexity influenced settler densities. Collectively, our results indicate habitat area is a primary, positive driver of faunal densities and generalist consumption, and therefore should be prioritized in seagrass conservation. However, sampling across spatial scales and habitat types revealed nuances in habitat use patterns among faunal guilds and life stages that were not solely area‐dependent, illustrating that a variety of landscape configurations support essential nursery functions.

Knowledge Transfer from High-Resource to Low-Resource Programming Languages for Code LLMs

Over the past few years, Large Language Models of Code (Code LLMs) have started to have a significant impact on programming practice. Code LLMs are also emerging as building blocks for research in programming languages and software engineering. However, the quality of code produced by a Code LLM varies significantly by programming language. Code LLMs produce impressive results on high-resource programming languages that are well represented in their training data (e.g., Java, Python, or JavaScript), but struggle with low-resource languages that have limited training data available (e.g., OCaml, Racket, and several others). This paper presents an effective approach for boosting the performance of Code LLMs on low-resource languages using semi-synthetic data. Our approach, called MultiPL-T, generates high-quality datasets for low-resource languages, which can then be used to fine-tune any pretrained Code LLM. MultiPL-T translates training data from high-resource languages into training data for low-resource languages in the following way. 1) We use a Code LLM to synthesize unit tests for commented code from a high-resource source language, filtering out faulty tests and code with low test coverage. 2) We use a Code LLM to translate the code from the high-resource source language to a target low-resource language. This gives us a corpus of candidate training data in the target language, but many of these translations are wrong. 3) We use a lightweight compiler to compile the test cases generated in (1) from the source language to the target language, which allows us to filter our obviously wrong translations. The result is a training corpus in the target low-resource language where all items have been validated with test cases. We apply this approach to generate tens of thousands of new, validated training items for five low-resource languages: Julia, Lua, OCaml, R, and Racket, using Python as the source high-resource language. Furthermore, we use an open Code LLM (StarCoderBase) with open training data (The Stack), which allows us to decontaminate benchmarks, train models without violating licenses, and run experiments that could not otherwise be done. Using datasets generated with MultiPL-T, we present fine-tuned versions of StarCoderBase and Code Llama for Julia, Lua, OCaml, R, and Racket that outperform other fine-tunes of these base models on the natural language to code task. We also present Racket fine-tunes for two very recent models, DeepSeek Coder and StarCoder2, to show that MultiPL-T continues to outperform other fine-tuning approaches for low-resource languages. The MultiPL-T approach is easy to apply to new languages, and is significantly more efficient and effective than alternatives such as training longer.

Full‐field effect of flow‐induced fiber orientation during compression molding of carbon fiber sheet molding compounds

AbstractAn image‐based fiber orientation analysis technique has been employed to study the effect of initial charge coverage and preferential fiber alignment on the flow‐induced fiber orientations in carbon fiber sheet molding compounds (SMCs). The initial charge coverage area exhibited minimal fiber reorientation while significant fiber alignment in the flow direction was observed in the regions of greatest flow. Novel subsurface analysis using the same full‐field orientation analysis technique also showed the presence of a skin‐core structure with greater flow‐induced fiber alignment at the mold surfaces, while the core retained more of the initial fiber orientation distribution. Edge effects were also revealed by this analysis at the mold walls. Tensile testing from two orthogonal directions showed that panels molded from lower charge coverage resulted in better mechanical performance and lower anisotropy. Moreover, by encouraging charge flow in the preform's preferential alignment direction, high tensile stiffness and strength in the preferred direction were achieved (56.7 GPa and 238.9 MPa, respectively) at 30% fiber volume fraction. This provides a practical demonstration of the value in controlling fiber orientation, with respect to charge positioning and mold flow, to maximize and tailor the composite performance of SMCs typically used for automotive applications.Highlights Low‐cost scanning technique is extended to assess internal fiber orientations Full‐field orientations are measured before and after molding Investigation of how charge size and shape can affect orientations Combining effects of flow and initial orientation to tailor SMC performance Circular statistics provides a thorough analysis of orientation distributions

A Phase II/III multicenter randomized single blind non-inferiority immunogenicity and safety study of TeddyVac™ vaccine of Human Biologicals Institute in healthy subjects of 10 years to 60 years of age

Background WHO and other health agencies recommend that tetanus toxoid (TT) should be replaced by tetanus-diphtheria (Td) vaccine taking into consideration the low coverage and waning immunity, especially for diphtheria. In this randomised, multicentre, non-inferiority study, the immunogenicity and safety of TeddyVac™ vaccine of Human Biologicals Institute were compared with an existing brand. Methods The study involved 444 eligible subjects in two age groups at four centres across India. Group A included subjects of 18–60 years and Group B subjects of 10–18 years of age. All subjects received single dose of either TeddyVac™ or the comparator vaccine as per randomisation. Blood samples for antibody titre estimation were collected before vaccination and 4–6 weeks after vaccination. Immunogenicity was assessed by estimating seroconversion rate, seroprotection rate, and geometric mean titres of antibodies. Safety was evaluated by collection and analysis of data on solicited and unsolicited adverse events. Results Overall, 441 subjects completed the study. Both the vaccine arms showed comparable seroconversion after a single dose for both the components. Both arms showed increase in seroprotection and geometric mean titres after a single dose of vaccination for both vaccine components, being significantly better for the diphtheria component in the test vaccine arm. Only few minor local and systemic adverse events were observed in both the vaccine arms. No serious adverse event was reported. Conclusion The study results indicate that the TeddyVac™ vaccine is immunogenic, safe and non-inferior to the comparator Vaccine when administered to healthy subjects of 10 to 60 years of age. CTRI Registration number CTRI/2021/07/035112

HyLight: Strain aware assembly of low coverage metagenomes

Different strains of identical species can vary substantially in terms of their spectrum of biomedically relevant phenotypes. Reconstructing the genomes of microbial communities at the level of their strains poses significant challenges, because sequencing errors can obscure strain-specific variants. Next-generation sequencing (NGS) reads are too short to resolve complex genomic regions. Third-generation sequencing (TGS) reads, although longer, are prone to higher error rates or substantially more expensive. Limiting TGS coverage to reduce costs compromises the accuracy of the assemblies. This explains why prior approaches agree on losses in strain awareness, accuracy, tendentially excessive costs, or combinations thereof. We introduce HyLight, a metagenome assembly approach that addresses these challenges by implementing the complementary strengths of TGS and NGS data. HyLight employs strain-resolved overlap graphs (OG) to accurately reconstruct individual strains within microbial communities. Our experiments demonstrate that HyLight produces strain-aware and contiguous assemblies at minimal error content, while significantly reducing costs because utilizing low-coverage TGS data. HyLight achieves an average improvement of 19.05% in preserving strain identity and demonstrates near-complete strain awareness across diverse datasets. In summary, HyLight offers considerable advances in metagenome assembly, insofar as it delivers significantly enhanced strain awareness, contiguity, and accuracy without the typical compromises observed in existing approaches.