PurposeTo evaluate the image quality of early postoperative CT angiography with low contrast material and radiation dose using model-based iterative reconstruction (FIRST) for screening pseudoaneurysms after partial nephrectomy. MethodsCT angiography was obtained before surgery using conventional iterative dose reduction reconstruction (AIDR 3D) with 120 kVp and 600 mgI/kg of contrast material and obtained after partial nephrectomy using FIRST with 80–100 kVp and 360 mgI/kg in 35 patients. Contrast-to-noise ratio, visual image quality scores using a 5-point scale, and longest length of the unaffected renal arteries on maximum intensity projection images were retrospectively compared between FIRST and AIDR 3D. ResultsNo significant differences existed in contrast-to-noise ratio or image quality scores of the renal arteries between FIRST and AIDR 3D (25.8 ± 6.6 vs. 25.4 ± 7.0, p = 0.991 and 4.8 ± 0.4 vs. 4.5 ± 0.9, p = 0.515, respectively). Visualization scores and longest length of the peripheral renal arteries in FIRST were significantly superior to those of AIDR 3D (4.3 ± 0.8 vs. 3.5 ± 1.0, p < 0.001 and 100.4 ± 14.9 mm vs. 90.2 ± 15.7 mm, p = 0.010, respectively). The dose-length product with FIRST was significantly lower than that with AIDR 3D (566.1 ± 217.4 mGy.cm vs. 829.8 ± 324.9 mGy.cm, p < 0.001). ConclusionFIRST can improve visualization of the peripheral renal arteries with contrast material and radiation dose reduced by approximately 30 % compared with AIDR 3D, which enables adequate evaluation of pseudoaneurysms after partial nephrectomy.