Targeted memory reactivation during sleep is a powerful tool to influence the mind. Current literature demonstrates memory strengthening following targeted memory reactivation (TMR) using sounds or odors (see Oudiette & Paller, 2013 for review). Here we investigate whether TMR-forget can successfully induce episodic memory loss. Eighteen participants were administered two learning tasks before sleeping. First, participants were trained on a forget cue where they viewed 46 words, half of which were followed by the cue. Then participants learned 28 novel object-location pairs that were paired with their associated sounds. From these objects, five were randomly chosen for reactivation and five others for controls. That night, during the first period of SWS, we reactivated the five objects with the forget tone 20 times each. Seven days later, we tested participants’ memories of the objects, their locations, and the words using free-recall and recognition. Seven days later, participants recalled fewer reactivated than control objects (t(1,17)=3.682 p = .002, Cohen’s d = 1.23). Reactivated objects that were not recalled were also less likely to be correctly located than those that were recalled (t(1,15) = -2.132 p = .05, Cohen’s d = .764) and had lower confidence ratings (t(1,15) = -5.558 p >.001, Cohen’s d = 1.983). No stage of sleep (N1, N2, N3, or REM) correlated with later forgetting (r’s ≥ -.177, p’s ≥ .383). N1, N2, and REM did not correlate with control retention (r’s ≥ .072, p’s ≥ .494), however we found a trending correlation for N3 (r = .465, p = .07). We demonstrate that TMR-forget can successfully induce episodic memory loss for objects one week later. Participants are less likely to recall the reactivated objects as well as less likely to correctly spatially locate those they successfully forgot. It will be important for future studies to determine whether TMR-forget can induce loss of emotional memories, which will lead the way for novel therapeutic interventions for disorders such as PTSD or specific phobias. Not applicable.