Low Arousal Condition Research Articles

Damage to the dorsomedial thalamic nucleus, central lateral intralaminar thalamic nucleus, and midline thalamic nuclei on the right-side impair executive function and attention under conditions of high demand but not low demand

This study reports a patient, OG, with a unilateral right-sided thalamic lesion. High resolution 3T magnetic resonance imaging revealed damage to the parvicellular and magnocellular subdivisions of the dorsomedial thalamus (DMT), the central lateral intralaminar nucleus (also known as the paralamellar DMT), the paraventricular and the central medial midline thalamic nuclei. According to the neuropsychological literature, the DMT, the midline and intralaminar thalamic nuclei influence a wide array of cognitive functions by virtue of their modulatory influences on executive function and attention, and this is particularly indicated under conditions of low arousal or high cognitive demand. We explored this prediction in OG, and compared his performance on a range of low and high demand versions of tests that tapped executive function and attention to a group of 6 age- and IQ-matched controls. OG, without exception, significantly underperformed on the high-demand attention and executive function tasks, but performed normally on the low-demand versions. These findings extend and refine current understanding of the effects of thalamic lesion on attention and executive function.

Depressed mood and blood pressure: The moderating effect of situation-specific arousal levels

Previous studies are inconclusive with regard to the relationship between variations in blood pressure (BP) and affect. In the present study we evaluated the hypothesis that inconsistencies in previous findings may be attributed to the moderating role of variations in psychological or physical conditions during BP measurement. Change in depressive symptoms was examined in 1046 individuals at two points in time, at inclusion into the study, when BP was measured repeatedly under higher (standing posture or anticipation of interview) and lower (supine posture or recovery after interview) arousal conditions, and at 4year follow‐up. We observed that higher systolic BP levels measured under high arousal conditions and lower systolic BP levels measured under low arousal conditions at inclusion were both associated with a decrease in depressive mood across time in the study sample. The results suggest that higher or lower cardiovascular activity as indexed by systolic BP corresponds with higher or lower negative mood as a function of situation-specific arousal levels. This biobehavioural association between mood and BP might be related to the moderating effect of adaptive processes on physiological activity in different situations, which may in turn be associated with resilience to adversity.

Vocal correlates of sender-identity and arousal in the isolation calls of domestic kitten (Felis silvestris catus).

IntroductionHuman speech does not only communicate linguistic information but also paralinguistic features, e.g. information about the identity and the arousal state of the sender. Comparable morphological and physiological constraints on vocal production in mammals suggest the existence of commonalities encoding sender-identity and the arousal state of a sender across mammals. To explore this hypothesis and to investigate whether specific acoustic parameters encode for sender-identity while others encode for arousal, we studied infants of the domestic cat (Felis silvestris catus). Kittens are an excellent model for analysing vocal correlates of sender-identity and arousal. They strongly depend on the care of their mother. Thus, the acoustical conveyance of sender-identity and arousal may be important for their survival.ResultsWe recorded calls of 18 kittens in an experimentally-induced separation paradigm, where kittens were spatially separated from their mother and siblings. In the Low arousal condition, infants were just separated without any manipulation. In the High arousal condition infants were handled by the experimenter. Multi-parametric sound analyses revealed that kitten isolation calls are individually distinct and differ between the Low and High arousal conditions. Our results suggested that source- and filter-related parameters are important for encoding sender-identity, whereas time-, source- and tonality-related parameters are important for encoding arousal.ConclusionComparable findings in other mammalian lineages provide evidence for commonalities in non-verbal cues encoding sender-identity and arousal across mammals comparable to paralinguistic cues in humans. This favours the establishment of general concepts for voice recognition and emotions in humans and animals.

The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness

Cannabinoid compounds may influence both emotional and cognitive processes depending on the level of environmental aversiveness at the time of drug administration. However, the mechanisms responsible for these responses remain to be elucidated. The present experiments investigated the effects induced by the endocannabinoid transport inhibitor AM404 (0.5–5 mg/kg, i.p.) on both emotional and cognitive performances of rats tested in a Spatial Open Field task and subjected to different experimental settings, named High Arousal (HA) and Low Arousal (LA) conditions. The two different experimental conditions influenced emotional reactivity independently of drug administration. Indeed, vehicle-treated rats exposed to the LA condition spent more time in the center of the arena than vehicle-treated rats exposed to the HA context. Conversely, the different arousal conditions did not affect the cognitive performances of vehicle-treated animals such as the capability to discriminate a spatial displacement of the objects or an object substitution. AM404 administration did not alter locomotor activity or emotional behavior of animals exposed to both environmental conditions. Interestingly, AM404 administration influenced the cognitive parameters depending on the level of emotional arousal: it impaired the capability of rats exposed to the HA condition to recognize a novel object while it did not induce any impairing effect in rats exposed to the LA condition. These findings suggest that drugs enhancing endocannabinoid signaling induce different effects on recognition memory performance depending on the level of emotional arousal induced by the environmental conditions.

Real-time physiological and vision monitoring of vehicle driver for non-intrusive drowsiness detection

This study presents a novel approach to detect driver's drowsiness by applying two distinct methods in computer vision and image processing. The objective of this study is to combine both methods under one single profile instead of relied solely on a detection method to enhance the driver's drowsiness detection resolution. Therefore a non-intrusive drowsy-monitoring system is developed to alert the driver if driver falls into low arousal state. In physiological part, photoplethysmography (PPG) is analysed for its changes in signals waveform from awake to drowsy state. Meanwhile, eyes pattern or motion in image processing is addressed to detect driver fatigue. Genetic algorithm with template-matching approach is designed to detect eye region and estimate the drowsiness in different metric standard based on eyes behaviour. Moreover, PPG drowsy signals are integrated with eyes motion to derive the final probability model for delivering valid and reliable drowsiness detection system. Indeed, the proposed system provides high competitive edge over existing arbitrary drowsiness detection system where the driver's health and mental states can be monitored in real-time without constraints.

N3 call types produced long-term by a killer whale of the northern resident community under controlled conditions: Characteristics, variation, and behavioral context

A-Clan of the Northern Resident killer whale (Orcinus orca) community produces a dialect of discrete stereotyped vocalizations, including N3, a call found in all pods of the clan. Ford (1984) reported that N3 is produced almost exclusively in low-arousal states. A 45-yr old female (BC-F1) collected from the A23 matriline of A5 pod and held under controlled conditions has produced this call throughout her adult life. Her calls were collected in 1985 at Marineland of the Pacific (14.25 h of samples) and every few years from 1987 to 2010 at Sea World San Diego (252 h). Analysis of the data show that BC-F1 uses two stereotyped variations of the N3 call. While temporally and structurally similar, there is a positive and negative frequency inflection distinguishing them. BC-F1 delivers N3 with the positive-inflected call preceding the negative. The N3 call occurs in low-arousal states, but also in high-arousal states, including caller interruption, breaking-up of synchronous swimming, and percussive behavior. N3 is infrequently produced during affiliative synchronous swimming and call-matching bouts. Thus, the call is not simply an indication of the resting state but transitions from one state to another. [Research supported by the author's organizations with in-kind support from SeaWorld San Diego.]

Using judgement bias to measure positive affective state in dogs

Interest in the induction and measurement of positive affective states in non-human animals is increasing. Here, we used a test of cognitive (judgement) bias, based on the finding that individuals experiencing different affective states judge ambiguous stimuli differently, to measure whether a positive low arousal affective state (e.g. ‘satisfaction’/‘contentment’) could be induced in domestic dogs as a result of their experiencing a food-based rewarding event. In this rewarding event, subjects (1 year old female Beagles) had to search for small amounts of food randomly placed within a maze arena. Using a balanced within-subjects design, the dogs ( N = 12) received a cognitive bias test either without experiencing the rewarding event (the ‘Neutral’ treatment), or directly after experiencing the rewarding event (the ‘Post-consumption’ treatment). In the test, dogs were trained that one visual cue (e.g. dark grey card) predicted a positive event (food in a bowl) whilst a different cue (e.g. light grey card) predicted a relatively ‘negative’ event (empty bowl). We hypothesised that dogs tested after experiencing the rewarding event, and in a presumed post-consummatory positive affective state, would be more likely to judge visually ambiguous stimuli (intermediate grey cards) positively, compared to dogs in the ‘Neutral’ treatment. In contrast, we found that they took significantly longer to approach an intermediate ambiguous stimulus, suggesting that they were less likely to anticipate food (a negative judgement) compared to dogs in the ‘Neutral’ treatment group. Various explanations for the observed results are discussed, in particular how reward acquisition and consumption may influence positive affective state induction in animals.

A startling absence of emotion effects: Active attention to the startle probe as a motor task cue appears to eliminate modulation of the startle reflex by valence and arousal

Research has shown that during emotional imagery, valence and arousal each modulate the startle reflex. Here, two imagery-startle experiments required participants to attend to the startle probe as a simple reaction time cue. In Experiment 1, four emotional conditions differing in valence and arousal were examined. Experiment 2, to accentuate potential valence effects, included two negative high arousal, a positive high arousal and a negative low arousal condition. Imagery effectively manipulated emotional valence and arousal, as indicated by heart rate and subjective ratings. Compared to baseline, imagery facilitated startle responses. However, valence and arousal failed to significantly affect startle magnitude in both experiments and startle latency in Experiment 1. Results suggest that emotional startle modulation is eclipsed when the probe is significant for task completion and/or cues a motor response. Findings suggest that an active, rather than defensive, response set may interfere with affective startle modulation, warranting further investigation.

Affective modulation of the acoustic startle: Does sadness engage the defensive system?

It has been suggested that high arousal negative affective states, but not low arousal negative affective states, potentiate the startle response. Because sadness has generally been studied as a low arousal emotion, it remains unclear whether high arousal sadness would produce startle potentiation to a similar degree as high arousal fear. To address this issue, 32 participants viewed two sets of 10-min film clips selected to induce two affective states of high subjective arousal (fear, sadness) and a neutral state of low subjective arousal, while the eyeblink startle response associated with brief noise bursts was assessed using orbicularis oculi EMG. Larger blink magnitude was found for fearful than for sad or neutral clips. Implications for conceptualizing sadness are discussed.

The Influence of Carbon Dioxide on Brain Activity and Metabolism in Conscious Humans

A better understanding of carbon dioxide (CO(2)) effect on brain activity may have a profound impact on clinical studies using CO(2) manipulation to assess cerebrovascular reserve and on the use of hypercapnia as a means to calibrate functional magnetic resonance imaging (fMRI) signal. This study investigates how an increase in blood CO(2), via inhalation of 5% CO(2), may alter brain activity in humans. Dynamic measurement of brain metabolism revealed that mild hypercapnia resulted in a suppression of cerebral metabolic rate of oxygen (CMRO(2)) by 13.4% ± 2.3% (N=14) and, furthermore, the CMRO(2) change was proportional to the subject's end-tidal CO(2) (Et-CO(2)) change. When using functional connectivity MRI (fcMRI) to assess the changes in resting-state neural activity, it was found that hypercapnia resulted in a reduction in all fcMRI indices assessed including cluster volume, cross-correlation coefficient, and amplitude of the fcMRI signal in the default-mode network (DMN). The extent of the reduction was more pronounced than similar indices obtained in visual-evoked fMRI, suggesting a selective suppression effect on resting-state neural activity. Scalp electroencephalogram (EEG) studies comparing hypercapnia with normocapnia conditions showed a relative increase in low frequency power in the EEG spectra, suggesting that the brain is entering a low arousal state on CO(2) inhalation.

The creative brain – Revisiting concepts

Creativity is a complex neuro-psycho-philosophical phenomenon which is difficult to define literally. Fundamentally it involves the ability to understand and express novel orderly relationships. The creative process involves four stages--preparation, incubation, illumination and verification. A high level of general intelligence, domain specific knowledge and special skills are necessary pre-requisites. It is possible that in addition, some creative people might have architectural alternations of specific portions of the posterior neocortex. Associated with such pre-requisites, the process of creative innovation (incubation and illumination stages) necessitates the need for an ability of divergent thinking, a novelty seeking behavior, some degree of suppression of latent inhibition and a subtle degree of frontal dysfunction. The author hypothesizes that these features are often inter-linked and subtle frontally disinhibited behavior is conducive towards creativity by allowing uninterrupted flow of creative thought possessing and opening up new avenues towards problem solving. Perhaps the most essential feature of the creative brain is its degree of connectivity--both inter-hemispheric and intra-hemispheric. Connectivity correlates or binds together functions of apparently structurally isolated domains on brain modules sub-serving different functions. It is felt that creative cognition is a self rewarding process where divergent thinking would promote connectivity through development of new synapses. In addition, the phenomenon of synaesthesia has often been observed in creative visual artists. Creative innovation often occurs during low arousal states and creative people often manifests features of affective disorders. This suggests a role of neurotransmitters in creative innovation. Dopaminergic pathways are involved in the novelty seeking attitude of creative people while norepinephrine levels are depressed during discovery of novel orderly relationships. The relationship between mood and catecholamines and that of creative cognition is often in an inverted U-shaped form. It is hypothesized that that subtle frontal dysfunction is a pre-requisite for creative cognition but here again the relationship is also in an inverted U-form.

Inappropriate conclusions in research on assisted dying

<h3>Abstract</h3> Because attention is limited in capacity and costly to utilize, organisms must continuously match their attentional intensity to its utility. Autonomic arousal strongly influences attention, but classical models give...

Anger, sadness and bear markets

Can an understanding of mood help us understand aspects of systematic risk, volume and portfolios’ exposure to systematic risk during bear-market regimes? We hypothesize that bear markets are associated with negative emotions: either a low-arousal negative state (e.g. sadness and depression) or a high-arousal negative state (e.g. anger and stress). We define a bear market as a stock market regime where the average return is statistically significantly lower than zero and find evidence that the bear market of November 1987 to February 1988 behaved as if it was associated with a pervasive low-arousal negative state amongst investors.

Experimental Evidence of the Knowledge Gap: Message Arousal, Motivation, and Time Delay

This study experimentally tested the knowledge gap from an information processing perspective. Specifically, knowledge acquisition was investigated under conditions of medium and low news message arousal, with time delay. Results show the persistence of a knowledge gap, particularly for low arousing messages. In fact, at low levels of message arousal, the gap is larger than at medium levels of arousal. Some existing research suggests that message salience explains the knowledge gap. Findings from this study show that information processing aptitude may also be a significant factor. Measures of several dimensions of participant motivation to cognitively engage with news messages were added as covariates to statistical analyses. These were found not to affect the knowledge gap outcomes in this data set.

Arousal and Attention: Self-chosen Stimulation Optimizes Cortical Excitability and Minimizes Compensatory Effort

Cortical excitability is assumed to depend on cortical arousal level in an inverted U-shaped fashion: Largest (optimal) excitability is usually associated with medium levels of arousal. It has been proposed that under conditions of low arousal, compensatory effort is exerted if attentional demands persist. People tend to avoid this resource-consuming top-down compensation by creating or selecting environmental conditions that provide sufficient bottom-up stimulation. These assumptions were tested in an attention-demanding dual-task situation: We combined a simulated driving task to induce three different arousal levels by varying stimulation (high vs. low vs. self-chosen) with a visual two-stimulus paradigm to assess cortical excitability by the initial contingent negative variation (iCNV) component of the event-related potential. Additionally, we analyzed the oscillatory power of the beta2 band of the electroencephalogram at anterior frontal sites, which is assumed to reflect low-arousal compensatory activity. The iCNV amplitude differed in all three arousal conditions as expected: It was highest in the condition of self-chosen stimulation and lowest in the low- and high-arousal conditions. Additionally, in the low-arousal condition, anterior frontal beta2 power was found to be significantly higher than in the other two conditions and correlated positively with subjective strain. This pattern of results suggests that subjects select medium levels of stimulation which optimize cortical excitability under attentional demand conditions. The elevated fronto-central beta2 power in the low-stimulation condition may indicate the involvement of the anterior cingulate cortex in compensating for reduced arousal by top-down stimulation of the noradrenergic arousal system.

Noradrenergic activity during non-REM sleep and memory consolidation

Event Abstract Back to Event Noradrenergic activity during non-REM sleep and memory consolidation Steffen Gais1*, B. Rasch1 and J. Born1 1 Department of Neuroendocrinology, University of Lübeck, Germany In spite of the long-standing assumption that noradrenergic activity during sleep mainly reflects the state of low arousal, recent research has demonstrated that the locus coeruleus (LC), which is the main source of neocortical noradrenaline, displays periods of intense firing also when the organism is showing no signs of wakefulness. These transient LC activations occur during slow-wave sleep in response to preceding learning episodes. Here, we manipulate noradrenergic availability during sleep by administration of the α2-autoreceptor agonist clonidine, which blocks LC activity, or by administration of the noradrenaline reuptake inhibitor reboxetine. We show that blockade of noradrenergic activity during sleep, but not during wakefulness, impairs subsequent memory performance in an odour recognition task. Increasing noradrenergic availability during sleep with reboxetine, on the other hand, enhances subsequent memory performance. Thus, we conclude that noradrenergic activity during non-REM sleep does not merely reflect reduced responsiveness of the brain, but has an important functional role in memory consolidation. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008. Presentation Type: Oral Presentation Topic: Memory & Learning Citation: Gais S, Rasch B and Born J (2008). Noradrenergic activity during non-REM sleep and memory consolidation. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.249 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 09 Dec 2008; Published Online: 09 Dec 2008. * Correspondence: Steffen Gais, Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany, gais@kfg.mu-luebeck.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Steffen Gais B. Rasch J. Born Google Steffen Gais B. Rasch J. Born Google Scholar Steffen Gais B. Rasch J. Born PubMed Steffen Gais B. Rasch J. Born Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

In a Working Mood?

Abstract. This quasi-experimental study examined the effects of exposure to a computer game on arousal and subsequent task performance. After inducing a state of low arousal, participants were assigned to experimental or control conditions via self-selection. Members of the experimental group played a computer game for five minutes; subjects in the control group spent the same amount of time awaiting further instructions. Participants who were exposed to the computer game showed significantly higher levels of arousal and performed significantly better on a subsequent cognitive task. The pattern of results was not influenced by the participants' prior experience with the game. The findings indicate that mood-management processes associated with personal media use at the workplace go beyond the alteration of arousal and affect subsequent cognitive performance.

The amplitude and phase precision of 40 Hz auditory steady-state response depend on the level of arousal

The aim of this study was to investigate, in healthy subjects, the modulation of amplitude and phase precision of the auditory steady-state response (ASSR) to 40 Hz stimulation in two resting conditions varying in the level of arousal. Previously, ASSR measures have shown to be affected by the level of arousal, but the findings are somewhat controversial. Generally, ASSR is diminished in sleep but it may be increased in drowsiness. Besides, ASSR reduction has been observed in schizophrenia. However, schizophrenic patients are known to have a disturbance of arousal level, what makes it pertinent to know the effects of fluctuations in arousal on passive response to gamma-range stimulation. In nine healthy volunteers trains of 40 Hz click stimuli were applied during two conditions: in the "high arousal" condition subjects were sitting upright silently reading a book of interest; in the "low arousal" condition subjects were sitting in a reclined position with eyes closed and the lights turned off. The 64-channel EEG data was wavelet transformed and the amplitude and phase precision of the wavelet transformed evoked potential were decomposed by the recently proposed multi-subject non-negative multi-way factorization (NMWF) (Morup et al. in J Neurosci Methods 161:361-368, 2007). The estimates of these measures were subjected to statistical analysis. The amplitude and phase precision of the ASSR were significantly larger during the low arousal state compared to the high arousal condition. The modulation of ASSR amplitude and phase precision by differences in the arousal level during recording warrants caution when investigating oscillatory brain activity and interpreting the findings of reduced ASSR in schizophrenia. It also emphasizes the necessity of standardized recording procedures and monitoring the level of arousal during ASSR testing.

Emotions and False Memories

The effects of mood on false memories have not been studied systematically until recently. Some results seem to indicate that negative mood may reduce false recall and thus suggest an influence of emotional valence on false memory. The present research tested the effects of both valence and arousal on recall and recognition and indicates that the effect is actually due to arousal. In fact, whether participants' mood is positive, negative, or neutral, false memories are significantly more frequent under conditions of high arousal than under conditions of low arousal.

The cognitive interview: Is its benefit affected by the level of witness emotion?

This research investigated whether a witness's emotion could influence the accuracy of statements obtained by the use of a cognitive interview. A total of 70 first-year university students viewed a video depicting a road accident. Electrodes were attached to their arms in order to send fictitious electric shocks during the video (high-arousal condition) or to measure physiological signs (low-arousal condition). One week later, they were interviewed using either a cognitive interview (CI) or a structured interview (SI). It was hypothesised that the beneficial effect of the cognitive interview would be amplified by a high level of arousal, particularly concerning central aspects of the video. Results indicated that a CI elicited more correct central and peripheral details recalled, whatever the level of arousal inducted during the encoding of the to-be remembered event. Furthermore, high-arousal participants produced more accurate testimonies concerning peripheral details than participants exposed to a low level of arousal. No interaction between interview and emotion was found. The theoretical and practical implications for interviewing witnesses are described.