Lost Content Research Articles

錠剤粉砕によるβ‐メチルジゴキシン散剤の付着性

Beta-methyldigoxin (MD), a new semi-synthesized cardiac glycoside, has been widely used for treatment of congestive heart failure. Since any dosage form other than tablet form is not commercially available for MD, it has been necessary to prepare powder by pulverizing the tablet when dose adjustment is required. It has recently been suggested that the loss of content in digoxin powder is caused by adhesion to the wrapping papers. In the present study, we examined the content-uniformity and adhesiveness of MD in powder by pulverizing. In addition, we investigated the effect of magnesium stearate, a lubricant, on the adhesion of MD to wrapping paper.The content and content-uniformity of MD in powders were influenced by the numbers of tablet, namely, the amount of preparation. The extent of lost content and the variation in content-uniformity of MD increased with a decrease in the number of tablets. There was large adhesion of MD to wrapping papers. The percentage of MD lost by adhesion became exceedingly greater when the amount of powder per package became smaller. Furthermore, the percentage of MD lost in powder increased after dividing and packing by automatic machine, ranging from 17.1 to 37.3% of the initial value. When one package contained a small amount of powder, there was no remarkable effect of the lubricant on loss of MD after dividing and packing. This study confirms that attention should be given to prevent the possibility of MD content being lost in practical use.

John Ireland: a catalogue, discography, and bibliography

John Ireland (1879-1962) was one of the leading composers of the so-called English musical Renaissance at the end of the 19th and beginning of the 20th century. Born of literary parents in Bowdon, near Manchester, he came to London at the age of 14 to study at the newly-founded Royal College of Music, where he eventually became a pupil of Stanford's. He is best known for his songs (Sea Fever, The Bells of San Marie and the cycle of Housman settings, The Land of Lost Content), his piano and chamber music, and his relatively small number of choral, orchestral and brass band works. This catalogue of Ireland's compositions, published in association with the John Ireland Trust, lists all his compositions from 1895 to 1961. Full details are given of dates of compositions, people or bodies responsible for a work's commission, instrumentations, first performance, publications, the location of the autographed manuscript, critical comment in the bibliography, and significant recordings. Appended are notes in the form of commentaries on the background to a work, commissions which did not come to fruition, and biographical information about the composer and dedicatees, mainly drawn from original documentary sources, especially letters.

Housman's Land of Lost Content: A Critical Study of "A Shropshire Lad."

Housman's Land of Lost Content: A Critical Study of "A Shropshire Lad."

Tibet: Its History, Religion and People and From the Land of Lost Content: The Dalai Lama's Fight for Tibet

Journal Article Tibet: Its History, Religion and People and From the Land of Lost Content: The Dalai Lama's Fight for Tibet Get access Tibet: Its History, Religion and People. By Thubten Jigme Norbu and Colin M. Turnbull. London: Chatto & Windus. 1969. 352 pp. 42s.From the Land of Lost Content: The Dalai Lama's Fight for Tibet. By Noel Barber. London: Collins. 1969. 224 pp. Bibliog. 30s. John Morris John Morris Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 46, Issue 3, July 1970, Pages 618–619, https://doi.org/10.2307/2613301 Published: 01 July 1970