You have accessJournal of UrologyTrauma/Reconstruction: Trauma & Reconstructive Surgery1 Apr 201199 A COMPARISON OF URETHRAL STRICTURE FORMATION IN A PORCINE LARGE ANIMAL MODEL WITH HUMAN STRICTURE DEVELOPMENT Jörg Seibold, Christin Selent-Stier, Julia Wiedemann, Tim-Oliver Greiner, Elisabeth Gustafsson, Brigitte Schuhmacher, Gerhard Feil, Arnulf Stenzl, and Karl-Dietrich Sievert Jörg SeiboldJörg Seibold Tübingen, Germany More articles by this author , Christin Selent-StierChristin Selent-Stier Tübingen, Germany More articles by this author , Julia WiedemannJulia Wiedemann Tübingen, Germany More articles by this author , Tim-Oliver GreinerTim-Oliver Greiner Tübingen, Germany More articles by this author , Elisabeth GustafssonElisabeth Gustafsson Tübingen, Germany More articles by this author , Brigitte SchuhmacherBrigitte Schuhmacher Tübingen, Germany More articles by this author , Gerhard FeilGerhard Feil Tübingen, Germany More articles by this author , Arnulf StenzlArnulf Stenzl Tübingen, Germany More articles by this author , and Karl-Dietrich SievertKarl-Dietrich Sievert Tübingen, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.164AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Urethral stricture has been described as a fibrotic process in scarred tissue that reduces the urethral lumen caliber. Urethral stricture development can be caused by indirect and direct trauma-like side effects of urethral slings for the urinary incontinence treatment and post transurethral prostate resection. The aim of the study was to establish a large animal model for the investigation of urethral stricture formation comparable to human stricture development. METHODS In 12 male Göttingen minipigs (mean body weight 20 kg) the stricture formation was evaluated with urethrography at 1, 8 and 12 weeks after stricture induction by ligation (L), urethrotomy (U), or thermocoagulation (T). The effect of urethral damage was investigated for the microvessel density (anti-von Willebrand factor antibody) and calculation of the collagen I/III ratio after western blot analysis. Normal human urethral tissue of 3 patients and stricture tissue of another 3 patients were compared to those of animal specimens. RESULTS Postoperatively all 12 animals developed a stricture in the injured area. The animal urethral stricture formation was characterized by the loss of tissue integrity in early phases of stricture development compared to normal tissue. However, over time an increase of connective tissue, a narrowing of urethral lumen, a significant decrease of microvessel density (p<0.001), and a significantly increased collagen I/III ratio (p<0.001) was noted. The three methods for stricture induction resulted in different severities of stricture formation in the animal model (T>L>U). In normal human urethral tissue a 1.9 fold higher expression of collagen type I compared to collagen type III was observed. In human stricture tissue samples the collagen type I/III ratio showed a mean ratio of 4.8:1. Microvessel density was significantly reduced in human urethral stricture tissue compared to normal human urethral tissue (p<0.001). CONCLUSIONS A large animal model to study urethral stricture formation after iatrogenic surgical interventions was successfully developed. The findings demonstrated a direct clinical context to human urethral strictures. The animal model enables investigations on new therapeutic approaches for urethral stricture therapy, e. g. based on tissue engineering. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e42 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jörg Seibold Tübingen, Germany More articles by this author Christin Selent-Stier Tübingen, Germany More articles by this author Julia Wiedemann Tübingen, Germany More articles by this author Tim-Oliver Greiner Tübingen, Germany More articles by this author Elisabeth Gustafsson Tübingen, Germany More articles by this author Brigitte Schuhmacher Tübingen, Germany More articles by this author Gerhard Feil Tübingen, Germany More articles by this author Arnulf Stenzl Tübingen, Germany More articles by this author Karl-Dietrich Sievert Tübingen, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...