Mean Loss Research Articles

Optimisation du transfert de planification de la distraction ostéogénique mandibulaire par dispositif externe sur mesure

The aim of this study was to analyze the predictability of virtual surgical planning of mandibular reconstruction by osteogenic distraction (OD) with a custom-made osteogenic distraction device (DEOS) after ballistic trauma and to make recommendations to mitigate potential sources of discrepancy. This retrospective study involved 12 patients who were victims of facial mandibular ballistic trauma and were reconstructed with osteogenic distraction with a DEOS device. Postoperative images were compared to the planned situation by means of several measures made in two plans: distraction plane and frontal plane. The mean bone loss was 54.2mm. The anteroposterior difference was systematically inferior or equal postoperatively (10.8mm). The interrami angle difference in the frontal plane was positive, with an average of 4.8°. There was a significant negative correlation in univariate analysis between the antero-posterior difference measurement and the difference of the interrami angle in distraction. A significant difference between the planning and postoperative results was shown, explained by the device being too adjustable leading to the loosening of the locking screws of the device. A static analysis showed that there are significant rotational forces at the carriages, which can lead to the loosening of the locking elements. It is then proposed that the device be optimized by customization of some elements.

One-Piece Zirconia Oral Implants for the Support of Three-Unit Fixed Dental Prostheses: Three-Year Results from a Prospective Case Series.

The objective was to investigate the clinical and radiological outcome of one-piece zirconia oral implants to support three-unit fixed dental prostheses (FDP) after three years in function. Twenty-seven patients were treated with a total of 54 implants in a one-stage surgery and immediate provisionalization. Standardized radiographs were taken at implant placement, after one year and after three years, to evaluate peri-implant bone loss. Soft-tissue parameters were also assessed. Linear mixed regression models as well as Wilcoxon Signed Rank tests were used for analyzing differences between groups and time points (p < 0.05). At the three-year evaluation, one implant was lost, resulting in a cumulative survival rate of 98.1%. The mean marginal bone loss amounted to 2.16 mm. An implant success grade I of 52% (bone loss of ≤2 mm) and success grade II of 61% (bone loss of ≤3 mm) were achieved. None of the evaluated baseline parameters affected bone loss. The survival rate of the zirconia implants was comparable to market-available titanium implants. However, an increased marginal bone loss was observed with a high peri-implantitis incidence and a resulting low implant success rate.

Feasibility of the abductor pollicis longus hemitendon transfer for thumb opposition: An anatomical study

IntroductionThe abductor pollicis longus (APL) presents two muscle bellies and multiple accessory tendons available for transfer, amongst these an accessory tendon inserting on the thenar aponeurosis (APLTh). Edgerton described an opponensplasty using the whole APL tendon, but its results were limited due to the short size of the donor tendon. HypothesisThe purpose of this study is to assess the feasibility of transferring the APLTh for thumb opposition. Material and methodsEleven cadaver upper limbs were dissected to assess the presence of the two heads of the APL as well as their main and accessory tendon insertions. The accessory tendon of the APL inserting on the thenar aponeurosis (APLTh) was harvested with a slip of the thenar aponeurosis. The length of the transplant, the number of tendon slips and their location, as well as pre and postoperative radial and palmar abduction provided by the APL were assessed. ResultsThe APL was present in all cadavers whereas its insertion on the thenar aponeurosis was absent in 18% of the cases. When the APLTh was present and could be used for opponensplasty, the mean gain in palmar abduction was 16 degrees, and the mean loss in radial abduction was 21 degrees. DiscussionAlthough the experiments revealed a variability in APL anatomy, when present, the APLTh represents a suitable donor for the restoration of thumb opposition. In some cases of high median nerve palsies, thumb opposition can’t be restored using median innervated muscles. In these cases, when the APLTh is present, it can be used to restore thumb opposition without functional loss. Level of evidenceIV; anatomical feasibility study.

Seismic Design Codes—Key Elements for Seismic Risk Perception and Reduction in Europe

Earthquakes are one of the most costly and deadliest natural disasters. This perspective paper presents a discussion focused on the role of seismic design codes in risk perception and seismic risk reduction in Europe. The seismic design codes are a key component for both the design of new buildings, as well as for the vulnerability assessment of existing ones. The impact of seismic design codes on seismic risk reduction is discussed using as case-study countries, Italy, Turkey, Greece, and Romania, which according to the recent European seismic risk model 2020 have the largest expected mean annual losses due to earthquakes. The evaluation of the seismic exposure of the four countries shows that from the entire population of more than 170 million people, about 130 million live in buildings designed using no or low level seismic design. The mean annual expected losses due to earthquakes are of the order of 0.1–0.2% of the national GDP. Moreover, the mean annual death probability due to earthquakes is 10−6 which represents a risk level not of great concern to the average people. However, large earthquakes in Europe from the past 50 years have produced losses in excess of 10 billion Euros and several hundred thousand affected people. A solution for a better communication of seismic risk in order to increase seismic risk perception might be to provide exceedance probabilities of specific macroseismic intensity levels for time frames of 10 or 20 years, instead of annual values. Macroseismic levels from past earthquakes might be used in order to have a better understanding of the results and should complement the seismic design maps. In addition, in the case of seismic vulnerability, the use of simple terms (e.g., inhabitable or uninhabitable) along with their associated occurrence probabilities in the same time frame as in the case of the seismic hazard, might be a solution. Financial incentives for seismic strengthening, as well as a clear definition of an earthquake-prone building are also very useful for increasing seismic risk perception.

Coastal Melaleuca wetlands under future climate and sea-level rise scenarios in the Mekong Delta, Vietnam: vulnerability and conservation

Melaleuca wetland ecosystems play crucial roles in ecology and human livelihood, yet the ecosystems are vulnerable to climate change and relative sea-level rise (SLR) impacts. Documents and research on climate change and SLR impacts on coastal Melaleuca wetlands in the Mekong Delta, Vietnam, are currently limited. Therefore, the present study aimed to identify changes in habitat suitability for a coastal Melaleuca wetland species in response to different future climate change and SLR scenarios, in the West Sea of the Mekong Delta, with the aid of an ensemble species distribution model (SDM) and the Sea Level Affecting Marshes Model (SLAMM). Melaleuca species occurrence records, bioclimatic and eco-physiological variables were utilized to predict potential distribution of the species in response to current and future climate scenarios (i.e. RCP4.5 and 8.5) for the year 2070. Wetland maps for 2020, a digital elevation model (DEM) and localized site-specific parameters (i.e. historic trend of SLR, erosion, subsidence and overwash) were utilized as input data for SLAMM to simulate spatial distribution of Melaleuca/forested wetlands under the two SLR scenarios. The final habitat suitability for the Melaleuca wetland species was identified based on these two resultant datasets, climatic suitability and spatial distribution of the wetlands. Simulated results suggested mean losses in suitable habitat of 29.8% and 58.7% for stable and subsidence scenarios, respectively, for the year 2070 in comparison to the baseline scenario. SLR combined with considerable subsidence rate was suggested as one of the main drivers responsible for the habitat suitability loss. The findings obtained from the current work are useful sources for planning conservation areas for the Melaleuca wetlands, to protect and preserve the ecosystems and their important services under future climate and SLR scenarios.

FIGURE OF SPEECH: SHIFT IN STYLE IN THE POETRY OF W.D HOWELLS AND T.S ELLIOT

This research aims to analyze the stylistic turn in the poems about Realism entitled "Dead" and "If" by William Dean Howell and “The Fire Sermon”and "The Burial of Dead" by T.S. Eliot about Modernism. This study uses Zienkowski's (2011) theory to show the language style embodied in literary works. This research uses a qualitative descriptive design to reveal and investigate the phenomenon of style embodied in the poet. The data taken are words, phrases, and sentences related to the discourse of beauty. Data to support this research is taken from articles, journals, websites, and previous studies with the same topic but with different objects. Based on theory and analysis, the researcher argues that the poem "If," an early poem by William, uses a lot of personification and metaphor to express strong feelings and ideas, often using the language of nature. Meanwhile, in the poem "Dead," William also displays a very contrasting style. The use of personification and metaphor. "Burial of the Dead" from "The Waste Land" uses a fragmented structure and a large number of metaphors and metonymies to depict the fragmentation and loss of meaning in society. In "The Fire Sermon," Eliot explores the spiritual and sexual disillusionment of the post-World War I era. He incorporates various metonymic sounds, allusions and imagery. Thus, this identification can reveal the correlation between the poetry of William Dean Howells and T.S Elliot.

A shelter from the abyss: exploring Cicely Saunders' vision of hospice care through the concept of worldview.

Over the past two decades, a debate has arisen concerning the history and philosophy of hospice and palliative care. This critical essay extends this debate by linking the analysis of Dame Cicely Saunders' writings with the concept of worldview, exploring the modern hospice movement vis-à-vis Saunders' approach to terminal care. Worldviews as cultural classifications of reality provide groups and individuals with meaning to navigate everyday and liminal situations. Using this concept in connection to the discipline of the sociology of knowledge, it is possible to grasp how the origins and principles of modern hospice care, from which current palliative care practices evolved, relate to the sociocultural environment of the postwar era in the West. The analysis focuses on a selected body of Saunders' writings, mainly written in the 1960s and 1970s, and discusses different components and functions of her revolutionary care paradigm. In this essay, I show that Saunders' vision of hospice care entails much more than a set of health care practices; it is a complex construct of knowledge and ideas that offers distinct procedures to shelter the dying from pain and loss of meaning. Her vision builds on medical advances and incorporates norms and attitudes related to secularised Protestant and New Age culture, which fostered privatised types of religion and individualistic ideologies and theodicies.

A Novel Approach: Tokenization Framework based on Sentence Structure in Indonesian Language

This study proposes a new approach in the sentence tokenization process. Sentence tokenization, which is known so far, is the process of breaking sentences based on spaces as separators. Space-based sentence tokenization only generates single word tokens. In sentences consisting of five words, tokenization will produce five tokens, one word each. Each word is a token. This process ignores the loss of the original meaning of the separated words. Our proposed tokenization framework can generate one-word tokens and multi-word tokens at the same time. The process is carried out by extracting the sentence structure to obtain sentence elements. Each sentence element is a token. There are five sentence elements that is Subject, Predicate, Object, Complement and Adverbs. We extract sentence structures using deep learning methods, where models are built by training the datasets that have been prepared before. The training results are quite good with an F1 score of 0.7 and it is still possible to improve. Sentence similarity is the topic for measuring the performance of one-word tokens compared to multi-word tokens. In this case the multiword token has better accuracy. This framework was created using the Indonesian language but can also use other languages with dataset adjustments.

Physicochemical characteristics of pork meatballs mixed with Amaranthus caudatus

The main objective was to compare the physicochemical characteristics of meatballs produced from pork meat and wheat flour mixed with Amaranthus caudatus. Meatballs were produced with two different formulations: meatballs without Amaranthus caudatus and meatballs having Amaranthus caudatus. The different parameters, such as temperature, PH, fat content, weight loss, and titratable acidity, were compared from one formulation to another. The results showed that the pH value and fat content of those having A. caudatus, were lower than those found in meatballs without A.caudatus, but the temperature, weight loss, and titratable acidity were more than those found in meatballs without A.caudatus. By this, the PH value for the initial time was 6.1 compared to 6.3, the meatball fat content without A. caudatus of about 3.7% than the meatball fat content with A. caudatus of about 2.9%, and the different weight loss between those two meatballs was 19.47% (59g), and finally, the titratable acidity was 1.8% in meatballs with A. caudatus than 0.26% in those without A. caudatus. The meatballs with A.caudatus had a greater acidity and lower lipids than the meatballs without A.caudatus. Also, the acid concentration of both meatballs has significant for consumers and the loss of weight means that the lowering of water content is an indication of a good storage process.

Surgical Treatment of Monteggia-Like Lesions With a Modified Boyd Approach.

Monteggia-like lesions are rare injuries in adults that include a wide spectrum of complex fracture-dislocations of the proximal ulna and radius. In this retrospective study, we performed a modified Boyd approach and a standard surgical protocol for the treatment of these lesions. Our aim was to evaluate the results of the operative treatment for patients with Monteggia-like lesions, using a modified Boyd approach. We present a retrospective study of 14 patients who underwent surgical treatment for Monteggia-like lesions. Preoperative clinical and radiological evaluation was performed. In 5 cases radial head prosthesis was placed, and in 3 cases the radial fracture was stabilized with the use of interfragmental screws. Regarding the proximal ulnar fracture, ORIF-anatomical plate and ORIF-straight plate was used in 12 and 2 cases, respectively. Average clinical follow up was 16.9 months. Postoperatively, the mean Mayo Elbow Performance score was 83.4 points (range 70-100) and the mean visual analog scale was 1.7 (range 0-14). Mean flexion and loss of extension were 122.1° (range 80°-140°) and 21.4° (range 5°-40°), respectively. Mean supination of the forearm was 66.8° (range 50°-80°) and the mean pronation was 67.5° (range 60°-75°). Heterotopic ossification was observed in 3 patients (21.4%) and 1 patient developed stiffness (7.1%). The patient who developed stiffness underwent reoperation for plate removal and arthrolysis, with satisfactory results. The surgical treatment of Monteggia-like lesions in adults remains a challenge. In the present study, the use of a standard surgical protocol, with a modified Boyd approach, successfully restores the movement and stability of the elbow, with a low complication rate.

Effect of local application of hyaluronic acid gel on marginal bone loss and stability of dental implants

ABSTRACT Aim: To evaluate and compare the crestal bone loss and implant stability with and without hyaluronic acid gel delivery at osteotomy site. Materials and Methods: This is a Prospective randomized controlled clinical trial. Eleven patients with 30 edentulous sites were randomly divided into two groups. Test (15 sites with hyaluronic acid gel injection) and Control (15 sites without hyaluronic acid gel injection). Peri-implant crestal bone loss around the implant and stability were measured at baseline and three months. Statistical analysis was done using Mann-Whitney U test and Wilcoxson Signed-Rank test. Results: Primary stability scores for the test and control groups were 70.45 ± 1.49 and 69.53 ± 1.69, respectively and was not statistically significant. Secondary stability scores for the test and control group were 72.37 ± 1.42and 70.63 ± 1.61 respectively and was statistically significant, mean crestal bone loss for the test and control groups was 0.83 ± 0.31 and 1.27 ± 0.32, respectively. which was statistically significant (p-value &lt; 0.05). Conclusion: Within the study’s limitations, the results showed that the local injection of osteotomy sites with hyaluronic acid showed a significant increase in stability and reduction in crestal bone loss.

Evaluation of Peri-Implant Crestal Bone Loss with Different Implant Systems, Primary Stability, Bone Density and Soft Tissue Thickness: A Retrospective Study.

The purpose of this retrospective study was to compare, among various implant systems, the influence of primary stability and the bone density and soft tissue biotype of the patient on the amount of peri-implant crestal bone loss after 1 year using radiography. Included in this retrospective study were patient records of 3583 implant placements utilized from an online dental information archiving software (DIAS). Clinical and radiographic assessments were conducted concurrently with implant placement (baseline) and 1 year post surgery. Statistical analysis was done to examine the mean marginal bone loss significance in the three different implant systems groups (group I: Straumann Roxolid SLAc-tive, group II: Nobel Biocare CC, group III: Straumann SLA), different primary stability values, different bone density. and soft tissue biotype at the time of implant placement. A significant difference was observed in the crestal bone loss with different implant systems used. Group I showed significantly lesser amounts of crestal bone loss when compared to groups II and III. However, the differences in the bone density, ISQ values, and the soft tissue biotype did not exhibit a statistically significant difference in the amount of crestal bone loss. Significant MBL preservation for implants with Straumann SLActive when compared to Nobel Biocare CC and Straumann SLA implants. No significant changes were observed with respect to primary stability, bone density, and soft tissue thickness and no correlation among early crestal bone loss and IT, ISQ at surgery, and ISQ at reopening was observed. Straumann Roxolid SLActive implants showed less crestal bone loss probably owing to its hydrophilic surface modification. However, more studies need to be done to evaluate the same.

Signal Conducting System with Effective Optimization Using Deep Learning for Schizophrenia Classification

Signal processing based research was adopted with Electroencephalogram (EEG) for predicting the abnormality and cerebral activities. The proposed research work is intended to provide an automatic diagnostic system to determine the EEG signal in order to classify the brain function which shows whether a person is affected with schizophrenia or not. Early detection and intervention are vital for better prognosis. However, the diagnosis of schizophrenia still depends on clinical observation to date. Without reliable biomarkers, schizophrenia is difficult to detect in its early phase and hence we have proposed this idea. In this work, the EEG signal series are divided into non-linear feature mining, classification and validation, and t-test integrated feature selection process. For this work, 19-channel EEG signals are utilized from schizophrenia class and normal pattern. Here, the datasets initially execute the splitting process based on raw 19-channel EEG into 6250 sample point’s sequences. With this process, 1142 features of normal and schizophrenia class patterns can be obtained. In other hand, 157 features from each EEG patterns are utilized based on Non-linear feature extraction process where 14 principal features can be identified in terms of considering the essential features. At last, the Deep Learning (DL) technique incorporated with an effective optimization technique is adopted for classification process called a Deep Convolutional Neural Network (DCNN) with mayfly optimization algorithm. The proposed technique is implemented into the platform of MATLAB in order to obtain better results and is analyzed based on the performance analysis framework such as accuracy, Signal to Noise Ratio (SNR), Mean Square Error, Normalized Mean Square Error (NMSE) and Loss. Through comparison, the proposed technique is proved to a better technique than other existing techniques.

Artificial Intelligence: First Do the Long Overdue Doable.

Release of ChatGPT-4, an internet-based computer program that simulates conversation with human users using Artificial Intelligence (AI) on March 14, 2023 set off a flurry of debates regarding the role and impact of AI on human life. Influential leaders and thinkers from diverse fields have chimed in to offer their views, admonitions, and or recommendations. There seems to be a great diversity in viewpoints and visions regarding how AI would affect human destiny-right from confident optimism to stark doomsaying and all in between. However, not much attention is being paid to the insidious long-term effects on human societies, many of them being unintended consequences, that AI has the potential to create over a short period of time. Perhaps the greatest threat of AI is the potential for loss of meaning in life and human-technology-created enfeeblement in a large section of humanity. All the other threats including that of the current AI are mere epiphenomena of this basic threat. In view of the fact that the genie of AI is out of the bottle and that it cannot be put back in, the first order of business for technologists, policy makers, and the governments is to allocate resources and attention to address the problem of meaning in life and mitigation of the sentiment of overwhelming and universal helplessness. Lastly, not to be optimistic about AI while being cautious and pragmatic is not an option.

Medial displacement calcaneal osteotomy: Loss of correction with varying drilling techniques

IntroductionJoint preserving surgery for flatfoot reconstruction utilizes correction of bony malalignment and medial soft tissue reconstruction. A medial displacement calcaneal osteotomy (MDCO) can be an essential adjunct to deformity correction and good patient outcomes. Our cadaveric study compares three different surgical techniques utilizing two cannulated screws to best maintain medial translation of the calcaneal osteotomies. Materials and methodsFifteen above knee fresh-frozen, matched pair cadaveric specimens (30 limbs) were randomized equally to three groups. MDCO were performed on all specimens, followed by manual 10 mm translation. The groups consisted of a “simultaneous drilling,” “staggered drilling,” and a control group, which involved simultaneous drilling of only the near cortex. Following screw fixation, the calcaneal tuberosity was manually translated in a lateral direction. The loss of correction was measured in millimeters. ResultsThe “simultaneous” drilling group experienced the greatest mean loss of correction at 2.6 mm (range 1.37–3.48 mm). The “staggered” group showed an average loss of 1.16 mm (range 0.36–2.67 mm). The control group demonstrated the greatest maintenance of correction with a mean loss of 0.036 mm (range 0.01–0.06 mm). ConclusionsMDCO realigns the hindfoot adding support to the medial soft tissue reconstruction during flatfoot correction. Loss of initial correction may result in residual deformity and poor long-term outcomes. Our study demonstrates that simultaneous drilling of only the tuberosity near cortex prior to screw fixation was the best at maintaining osteotomy correction. Level of evidence: Level V, Cadaveric study

Functional outcome of long-arm cast versus double sugartong splint in acute paediatric distal forearm fractures: A randomised controlled trial

Background: The treatment of choice for paediatric distal forearm fractures has been a long-arm cast (LAC) following closed reduction. An alternative treatment is to use a double sugar-tong splint (DSTS), found equally effective to provide three-point fixation and comparable outcomes to cast. Objectives: To compare the functional outcome between LAC and DSTS for the treatment of paediatric distal forearm fractures. Methods: A randomised controlled trial was done among 36 patients of 5-15 years with acute distal forearm fractures without neurovascular deficit treated with LAC and DSTS recruited by convenience sampling at a tertiary care centre after ethical approval. Acceptability of reduction, loss of reduction, union rates, cast comfort, range of motion and complications were studied at follow-up upto 12 weeks and analysed using SPSS v.11.5. Results: Among a total of 36 patients, 18 cases were treated by the LAC method and others by the DSTS method. Both LAC and DSTS were comparable in the maintenance of reduction, the remanipulation rate was 8.3% (n = 3), not significant (p-value = 0.967). All had a union at six weeks follow-up. No statistical difference in mean VAS score (p-value = 0.524), mean loss of flexion (p-value = 0.397), and mean loss of pronation/supination (p-value = 0.814). No statistically significant difference in activities of daily living was noted. No complications were encountered. Conclusion: DSTS is safe and as effective as LAC in the treatment of distal forearm fractures in children, identical in terms of functional outcome, maintenance of reduction, complications, and time to union.

Design and Testing of the Peanut Pod Cleaning Device

Due to the design of peanut harvesters and cleaners, peanut pods are often mixed with soil, gravel, peanut straw, and other impurities. To solve this problem, this study focused on designing a peanut pod cleaning device by integrating a negative pressure centrifugal fan, a hydrometric cleaning sieve, and a reversible long-mesh cleaning sieve. The relative motion of the peanut pod on the sieve was discussed, its stress analyzed, the design parameters of the sieve and fan determined, and the operation of the device was monitored by using sensors, which accurately recorded and adjusted the working parameters. Finally, the key parameters were tested, and the results showed that the design requirements were met at a vibration frequency of 5.5 Hz, a hydrometric cleaning sieve inclination of 15°, a reciprocating long mesh cleaning sieve inclination of 5°, and a fan speed of 1500 rev/min; the mean loss is 2.26%, and the mean impurity is 3.18%. The findings can be used to provide technical support and reference for the development of peanut pod cleaning devices.

Existential distress and meaning making among female breast cancer patients with cancer-related fertility concerns.

The current study explored the impact of cancer-related fertility concerns on existential distress and meaning making among female breast cancer (BC) patients of childbearing age and assessed support needs. The current study was embedded within a larger study. A seven-question online survey was administered to female BC participants to explore meaning and identity in their lives. Applied thematic analysis was used to analyze participants' written responses. A total of 98 participants completed the survey, the majority of whom identified as white, married or partnered, and employed full time and with stage I or II BC. More than 50% of the participants expressed a need for support from a counselor or support group during their cancer experience. Three subthemes emerged related to existential distress and cancer-related fertility concerns: (1) loss of womanhood: treatment-related physical changes impact on gender identity; (2) existential distress due to treatment decisions impacting fertility; and (3) shattered vision: cancer-related infertility impact on meaning and purpose. Four subthemes emerged related to meaning making with fertility-related existential concerns: (1) coping with loss of meaning, (2) re-evaluating priorities in life; (3) resilience to loss, and (4) persistent loss of meaning. Study results offer valuable insights into the experiences of female BC survivors' cancer-related fertility on existential distress and meaning making. Development of psychological interventions targeted to support this population to cope with existential distress due to cancer-related fertility concerns and meaning making are needed to improve the quality of life of this population.

Translation Solutions for Dealing With Ambiguity in Alice’s Adventures in Wonderland

"Translation solutions for dealing with ambiguity in Alice’s Adventures in Wonderland. This paper shows how different types of ambiguity embedded in the matrix of Lewis Carroll’s Alice’s Adventures in Wonderland (the 1993 edition) are dealt with in two prestigious Romanian translations – Frida Papadache’s Peripeţiile Alisei în Ţara Minunilor (1976) and Antoaneta Ralian’s Alice în Ţara Minunilor (2007) – as a tribute to the international appeal of Alice. My focal aim is to present a comparative analysis of the methods employed in translating Carroll’s equivocal lexical items, which make it increasingly difficult to match grammatical categories with function. This paper also aims at describing disambiguation techniques applied primarily in determining if the two translators managed to reinforce the original textual leeway at their disposal in the pure spirit of Carroll. My analysis relies heavily on Dirk Delabastita’s translation strategies as precautionary measures to cope with Carroll’s specialized type of literary discourse. The findings submitted by this paper are consistent with the idea that translating Carroll’s craft unavoidably entails a partial loss of meaning, brought about by the yawning gap between the intended message and interpretation, which can result in either overtranslation or undertranslation. The extensive use of double-entendre in the source-text cannot be recoded entirely in the target language, despite the translators’ excellent command of English. Keywords: Carrollian humor; ambiguity; translation solutions; disambiguation techniques; textual challenges "

Poczucie sensu życia kobiet w wieku średnim w sytuacji pandemii COVID-19. Studium przypadku

The sense of meaning in life is a basic human need, manifested in human aspirations and motivations. It is the result of a person’s development, resulting from the realisation of certain activities, values and life goals. Confronting difficult events, realising certain activities and making certain choices, a person discovers the meaning of his or her own life. The COVID-19 pandemic caused fear, a sense of isolation and economic insecurity. The hitherto normal life of many societies has been drastically and unexpectedly changed. The pandemic situation has contributed to a deterioration in physical and mental well-being. Loss of normality and grief over the difficulties of certain plans or intentions can contribute to a sense of emptiness, loss of meaning in life. The period of middle adulthood is a time of increased autonomy, detachment, self-analysis, and religious commitments. In middle adulthood, the question of the meaning of life and the hierarchy of values becomes particularly important. The midlife crisis and the first life balances can contribute to an increase in existential problems (related to the meaning of life, goals or life values). The aim of the article is to show the sources of a sense of meaning in life in middle-aged women in the COVID-19 pandemic situation. This case study shows the importance of three basic sources of a sense of meaning, which include creativity (realised activities), experiences (feeling connected to others) and attitude (deepening religious practices, finding deeper meaning in them, a different quality of relationship with God).