You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology II1 Apr 2017MP19-16 RENAL PAPILLARY PLUGGING IN CALCIUM STONE FORMERS MAY ARISE VIA RANDOM AND INDEPENDENT CRYSTALLIZATION EVENTS Melanie Adamsky, Andrew Cohen, Glenn Gerber, Elaine Worcester, and Frederic Coe Melanie AdamskyMelanie Adamsky More articles by this author , Andrew CohenAndrew Cohen More articles by this author , Glenn GerberGlenn Gerber More articles by this author , Elaine WorcesterElaine Worcester More articles by this author , and Frederic CoeFrederic Coe More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.3258AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The causes of renal papillary abnormalities observed endoscopically within a single kidney are incompletely known. One testable theory is that plugging, and perhaps Randall's plaque (RP), are random and independent events of crystallization whose risk is increased by local supersaturations. If so, their occurrence in the papillae of a kidney must follow the Gaussian distribution. Using scores from a previously introduced and validated papillary grading system, we sought to test if this is true. METHODS We reduced papillary grading scores from patients who had undergone unilateral ureteroscopic stone treatment to ″present″ or ″absent″ for each variable in the grading system - pitting, plugging, loss of contour, and RP. From this we calculated the proportion of graded papillae in a given kidney involved. Probability density functions were generated and Shapiro-Wilks (SW) and Anderson-Darling AD) tests of normality were applied. RESULTS Our cohort included 42 patients (42 kidneys), all of whom had calcium stones - 28 calcium oxalate and 14 calcium phosphate - on subsequent analysis. The mean number of papilla graded per kidney was 5.97 (95% CI 5.40-6.55). The mean proportion of papillae with plugging was 51.7% (±4.3), pitting was 20.1% (±3.0), loss of contour was 22.7% (±3.6), and RP was 33.7% (±4.0). Probability density functions are shown in Figure 1. Unlike pitting, loss of contour, and RP, plugging is uniquely normally distributed (SW and AD tests p>0.01). CONCLUSIONS Unlike pitting, loss of contour, and RP, plugging is uniquely normally distributed (SW and AD tests p>0.01), supporting that plugging is a random and independent process in individual papillae and plaque, pitting, and contour changes cannot be. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e236 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Melanie Adamsky More articles by this author Andrew Cohen More articles by this author Glenn Gerber More articles by this author Elaine Worcester More articles by this author Frederic Coe More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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