Loss Of Child Research Articles

Neurobiological mechanisms involved in maternal deprivation-induced behaviours relevant to psychiatric disorders.

Parental care is essential for proper development of stress response and emotion-related behaviours. Epidemiological studies show that parental loss in childhood represents a major risk factor for the development of mental disorders throughout the lifespan, including schizophrenia, depression, and anxiety. In most mammalian species, the mother is the main source of care and maternal behaviours regulate several physiological systems. Maternal deprivation (DEP) for 24 h is a paradigm widely used to disinhibit the hypothalamic-pituitary-adrenal axis response to stress during the stress hyporesponsive period. In this mini-review we will highlight the main DEP-induced neurobiological and behavioural outcomes, including alterations on stress-related hormones, neurogenesis, neurotransmitter/neuromodulatory systems and neuroinflammation. These neurobiological changes may be reflected by aberrant behaviours, which are relevant to the study of mental disorders. The evidence indicates that DEP consequences depend on the sex, the age when the DEP takes place and the age when the animals are evaluated, reflecting dynamic plasticity and individual variability. Individual variability and sex differences have a great relevance for the study of biological factors of stress resilience and vulnerability and the DEP paradigm is a suitable model for evaluation of phenotypes of stress- and emotion-related psychopathologies.

Problems of Learning the Qur’an in Early Childhood Education during the COVID-19 Pandemic

Purpose – The early learning of the Qur’an, infused with Islamic values, has been widely regarded as an effective tool in preserving the natural inclinations of children and nurturing their humanity. However, the ongoing COVID-19 pandemic has presented significant obstacles to Qur’an learning in Early Childhood Education (ECE) institutions. As such, this study seeks to offer a comprehensive description of the challenges faced by these institutions in delivering their teachings during this global health crisis.Design/methods/approach – The method used in this research is descriptive qualitative research. The location of this research was carried out at 4 ECE institutions. Namely: RA Al-Muslimun Nurul Islam, TKIT Asy-Syaamil Qur’anic Fullday School, Integrated Star Islamic Early Childhood Education, and RA Ulumul Qur’an Al Madani.Findings – The current COVID-19 pandemic has created significant challenges for learning the Qur’an in ECE. These issues can be categorized as internal and external factors. Internal factors relate to teachers’ difficulties when conducting practical learning activities outside the classroom. Meeting constraints, large class sizes, and limited time duration often result in an inability to deliver a complete learning experience. Externally, learning losses in early childhood have become apparent, with children experiencing behavioral changes. Not all parents are equipped to accompany their children in instilling Islamic values based on the Qur’an at home. This issue is compounded by parental objections to tuition fees, which creates financial challenges for institutions. Finally, offline learning has been the subject of criticism from the community, which indirectly affects the learning process.Research implications/limitations – This study used a qualitative method related to the problems of learning the Qur’an in ECE during the COVID-19 pandemic. Practical implications – The research presents significant implications for developing Al-Qur’an learning post-pandemic. It also provides valuable insights into formulating policies about Al-Qur’an learning during pandemics. Additionally, the study sheds light on the effectiveness of character building during the challenging times of the COVID-19 pandemic.Originality/value – Potential avenues for further investigation could include examining the effects of COVID-19 on the acquisition of Qur’anic knowledge during early childhood and its potential impacts on personality development. Such research could contribute to a deeper understanding of how the pandemic has influenced educational and psychological outcomes in this context.
 Paper type Research paper

Radiologic Imaging of Pediatric Hearing Loss

Hearing loss in childhood has serious consequences for the entire development of the child. It is very important to make an accurate early diagnosis. The assessment usually includes physical, genetic, and radiological examination. In imaging diagnostics, CT, Cone Beam CT and or MRI of the petrous bone are the usual imaging modalities for the assessment of diseases of mastoid air cells, middle ear, external ear, the cochlea, the vestibulocochlear nerve, and the brain.

In brief: Semaglutide (Wegovy) for weight loss in children.

The injectable glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide (Wegovy), which was approved by the FDA in 2021 for chronic weight management in adults,1 has now been approved for chronic weight management in children ≥12 years old with an initial BMI in the ≥95th percentile for age and sex.Semaglutide is also available as Ozempic and Rybelsus for treatment of type 2 diabetes in adults.

Vestibular Loss in Children Affected by LVAS and IP2 Malformation and Operated with Cochlear Implant.

This is a single center cohort study regarding the prevalence of vestibular loss in hearing impaired children affected by large vestibular aqueduct syndrome (LVAS) with incomplete cochlear partition malformation type II (IP2), fitted with cochlear implant (CI). Twenty-seven children received CI operations at 0.4-13 years on one or both ears and tested for vestibular loss with head impulse test, video head impulse test, mini ice-water test and cervical VEMP. Vestibular loss was found in 19% of operated ears and in 13.9% of non-operated ears. The difference was not statistically significant and was not significantly modified by age at implantation, age at testing, sex, presence of SLC26A4 gene mutation or bilaterality. However, the presence of anatomic anomalies at the level of the vestibulum or semicircular canals was significantly associated with a higher incidence of vestibular loss in CI operated children but not in those non-operated. No other factors, such as the surgical access, the electrode type, the presence of Gusher perioperatively, or post-operative vertigo modified significantly the prevalence of vestibular loss. In conclusion, LVAS/IP2 appears to be the major determinant of vestibular loss in these children, with a less obvious impact of CI, excluding the cases with vestibulum/canal anomalies: this group might have a higher risk for vestibular loss after CI surgery.

Global, Regional, and National Burdens of Blindness and Vision Loss in Children and Adolescents from 1990 to 2019: A Trend Analysis

To provide estimates for regional and national burdens of blindness and vision loss among children and adolescents between 1990 and 2019 by disease, age, and sociodemographic index (SDI). This was a retrospective demographic analysis based on aggregated data. This was a population-based study using 1990-2019 data on the burden of vision loss and blindness from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. The burden of vision loss and blindness was evaluated in terms of case numbers, rates per 100 000 population, and average annual percentage changes (AAPCs) in prevalence rates and years lived with disability (YLDs). Globally, the rates of blindness and vision loss per 100 000 population decreased in all age groups between 1990 and 2019, with prevalence rates decreasing from 1091.4 (95% uncertainty interval [UI], 895.2-1326.1) to 1036.9 (95% UI, 847.8-1265.9, AAPC, -0.2) and YLDs decreasing from 44.5 (95% UI, 28.1-66.5) to 40.2 (95% UI, 25.1-60.7, AAPC, -0.4). Most of these reductions in prevalence rates (AAPC, -0.2, 95% confidence interval [CI], -0.2 to -0.1) and YLDs (AAPC, -0.2, 95% CI, -0.3 to -0.2) were due to decreases in refractive disorder. Notably, near-vision loss prevalence (AAPC, 0.3, 95% CI, 0.2-0.4) and YLDs (AAPC, 0.3, 95% CI, 0.2-0.4) substantially increased in all age groups. Children and adolescents in low- and low-middle SDI countries exhibited substantial decreases in the prevalence rates and YLDs of blindness and vision loss, but their counterparts in high- and middle-high SDI countries experienced a substantial increase in prevalence. Globally, efforts in the past 3 decades have substantially decreased the burdens of blindness and vision loss among children and adolescents. However, there is extensive variation according to the kind of impairment, age group, and country SDI. The author(s) have no proprietary or commercial interest in any materials discussed in this article.

A Tale of Childhood Loss, Conditional Acceptance and a Fear of Abandonment: A Qualitative Study Taking a Narrative Approach to Eating Disorders.

Eating disorders (EDs) are serious mental health illnesses, yet there is a need to better understand the illness experience to improve treatment outcomes. Qualitative research, and narrative approaches in particular, can elicit life stories that allow for the whole illness journey to be explored. This study aimed to explore the experiences of women with a history of an ED, identifying the life events they perceived were relevant to the onset of their ED through to recovery. Interviews were conducted with 18 women with lived experience of an ED. Through structural narrative analysis, an overarching storyline of childhood loss contributing to a belief of conditional acceptance, fear of abandonment and struggle to seek emotional support due to the fear of being a burden was identified. Negative experiences with the health sector were common. These findings have implications for the way medical professionals respond to help seeking and deliver treatment.

Socio-Cultural Influencers of Disclosure of HIV Status to Children on Antiretroviral Therapy in the Masaka Region, Uganda: A Qualitative Study.

This study explored sociocultural influencers of disclosure of HIV status to children taking daily antiretroviral therapy (ART) in the Masaka region, Uganda using data collected from 26 key informant interviews with caregivers between October 2020 and July 2021. The findings revealed both positive and negative sociocultural influencers of disclosure. Beliefs that disclosure cultivates responsibility in the child to improve ART adherence and the culture of routine sexual health education conversations with children were positive socio-cultural influencers. Beliefs that disclosure increases children's loss of hope in life and breaks confidentiality with children inadvertently disclosing their HIV status to others leading to discrimination and social rejection, were key negative sociocultural influencers. These findings suggest a need for socio-culturally informed interventions that target caregiver negative socio-cultural disclosure influencers in this setting through contextualized sensitization and training to prepare children taking daily ART to receive disclosure progressively.

The Prevalence of Visual Acuity Impairment among Children in Nigeria – A Systematic Review

Background: Blindness is a major health problem, and there is an increasing trend of visual acuity impairment among children in developing countries. Vision loss in childhood has serious implications in all stages of a child's growth and development. It poses social, educational and occupational challenges, with affected children being at greater risk of developing behavioural, psychological and emotional problems, lower self-esteem and poorer social integration. The study aimed to assess the prevalence of visual impairment among children in Nigeria. Method: A systematic review of papers published on the prevalence of visual acuity impairment among children in the country was carried out. We covered works published in Google Scholar, PubMed, ResearchGate, ScienceDirect, and African Journals Online. Primary search terms included the combination of the following keywords; “prevalence”, “visual acuity”, “visual impairment”, “children”, “Nigeria”. The database search for published articles was done without date restriction till 1st December 2021. The review was restricted to primary research published in English and peer-reviewed journals. Results: Fourteen studies met the inclusion criteria out of the 56 studies reviewed. In Nigeria, the prevalence of visual acuity impairments ranged from 1.7% to 26.1%. Conclusion: The prevalence of visual acuity impairment among children in Nigeria is in epidemic proportions. There is a need to pay attention to proper health education; early detection and appropriate management of impaired vision to fight against this health disorder.

Joint exposure to parental cancer and income loss during childhood and the child’s socioeconomic position in early adulthood: a Danish and Norwegian register-based cohort study

BackgroundParental cancer as well as economic hardship in the family during childhood can affect the child negatively. Our aim was to examine the association between the joint exposure to parental...

Alternative splicing in CEP290 mutant cats results in a milder phenotype than LCACEP290 patients.

The rdAc cat has an intronic mutation in the centrosomal 290 kDa (CEP290) gene resulting in a frameshift and a premature stop codon (c.6960 + 9T > G, p.Ile2321AlafsTer3) predicted to truncate the protein by 157 amino acids. CEP290 mutations in human patients cause a range or phenotypes including syndromic conditions and severe childhood loss of vision while the rdAc cat has a milder phenotype. We sought to further characterize the effect of rdAc mutation on CEP290 expression. TaqMan quantitative real-time polymerase chain reaction assays were used to compare wildtype and truncated transcript levels. Relative protein abundance was analyzed by Western blot. Immunohistochemistry (IHC) was performed to detect CEP290 protein. CEP290 mutant cats show low-level (17.4% of wildtype cats) use of the wildtype splice site and usage of the mutant splice site. Western analysis shows retina from cats homozygous for the mutation has CEP290 protein that likely comprises a combination of both wildtype and truncated protein. IHC detects CEP290 in affected and control retina labeling the region of the interconnecting cilium. The comparably milder phenotype of CEP290 mutant cats is likely due to the retained production of some full-length CEP290 protein with possible functional contributions from presence of truncated protein.

Prevalence of Hearing Loss in Children of Parents with Consanguineous Marriages

Introduction: According to the World Health Organization, 6.1% of the world's population has hearing impairment, making it one of the most common disabilities. Congenital, prenatal, genetic, and environmental factors are among the many causes of hearing impairment. Congenital hearing loss is thought to be mostly caused by consanguinity. Numerous studies, both in the Middle East, where the practice is very common, and in Europe, where it is taboo, show a strong connection between congenital hearing loss and consanguinity. There is virtually little research on hearing loss brought on by consanguinity in the literature. Objective: The find the prevalence of hearing loss in children of parents with consanguineous marriages. Material & Methods: This an observational cross-sectional study. The study had a sample size of 377 subjects. The data was collected from Alam Audiology Clinic and Sir Ganga Ram Hospital for 6 months from January to June, 2022. The data was collected from parents who reported a consanguineous marriage, and the children were taken between the ages of 0.5 years to 5 years, children were test using various audiological intervention, i.e., Pure Tone. Audiometry, Otoacoustic emissions, Auditory Brain-stem Response. The children who were syndromic or had other associated psychological issues were excluded. A Performa was generated inquiring about demographics, nature of consanguinity, other disabilities type of hearing impairment and other risk factors, this was filled out by the parents or the researcher in consultation of the parents. All the parents were informed of the study and their consent was taken. The study data was analyzed using SPSS 21 and frequencies were found out, tables and charts were systematically drawn and their conclusions were drawn. The study followed all ethical parameters. Results: The results showed that out of the 377 participants, 186 were male and 191 were females, children of the age group 2-5 years were the most extensive numbering 323 participants (85.7%). An overwhelming number of children brought for assessment were with congenital hearing loss 286 (75.9%). Very few people reported hearing impairment in their family history. The nature of the cousin marriage shows that most of the participants 78.2% reported that they are first cousins. Most of the children 69% had moderate to severe hearing loss. Practical Implication: The study will show us the impact of consanguineous marriages have on the hearing capacity of their children. The study will highlight consanguineous marriages as a factor in hearing impairment. Keywords: Hearing loss, consanguinity, hearing impairment, hearing impairment.

Congenital Nonprofound Bilateral Sensorineural Hearing Loss in Children: Comprehensive Characterization of Auditory Function and Hearing Aid Benefit.

A prospective cross-sectional design was used to characterize congenital bilateral sensorineural hearing loss (SNHL). The underlying material of >30,000 consecutively screened newborns comprised 11 subjects with nonprofound, alleged nonsyndromic, SNHL. Comprehensive audiological testing was performed at ≈11 years of age. Results showed symmetrical sigmoid-like median pure-tone thresholds (PTTs) reaching 50–60 dB HL. The congenital SNHL revealed recruitment, increased upward spread of masking, distortion product otoacoustic emission (DPOAE) dependent on PTT (≤60 dB HL), reduced auditory brainstem response (ABR) amplitude, and normal magnetic resonance imaging. Unaided recognition of speech in spatially separate competing speech (SCS) deteriorated with increasing uncomfortable loudness level (UCL), plausibly linked to reduced afferent signals. Most subjects demonstrated hearing aid (HA) benefit in a demanding laboratory listening situation. Questionnaires revealed HA benefit in real-world listening situations. This functional characterization should be important for the outline of clinical guidelines. The distinct relationship between DPOAE and PTT, up to the theoretical limit of cochlear amplification, and the low ABR amplitude remain to be elucidated. The significant relation between UCL and SCS has implications for HA-fitting. The fitting of HAs based on causes, mechanisms, and functional characterization of the SNHL may be an individualized intervention approach and deserves future research.

Bilateral Orbital Tuberculosis with Unilateral Severe Irrversible Vision Loss in Children: A Case Report

Introduction: Tuberculosis is a transmissible infectious disease caused by mycobacterium tuberculosis. Ocular tuberculosis is rare representing between 1% to 18% of all forms of tuberculosis and only 0.3% of patients develop the orbital form. The focus is usually unilateral, we report through this observation a case of bilateral orbital tuberculosis in a 12 year old girl. Observation: A 12-year-old girl was admitted to the department of infectious and tropical diseases of the National Hospital of Zinder for long term fever and violent headache. The ophthalmological examination revealed a visual acuity of 1/10 on the right, absence of light perception on the left and bilateral exophthalmos. Biomicroscopic examination showed superficial punctate keratitis bilaterally, a normal fundus on the right and left atrophy. In view of the long-lasting fever and the biological inflammatory syndrome, the diagnosis of tuberculosis was evoked. The tuberculin intradermal test (IDR) was positive and the search for BK in the bronchial lavage revealed BAARs. HIV serology was negative. The standard chest X-ray was normal but the CT scan of the orbito- cerebral cavity showed two cystic foci with grade III exophthalmos. After 3 months of anticillary treatment the evolution was considered satisfactory. Conclusion: The orbital involvement of tuberculosis was generally unilateral, its bilateral localization is unusual. It must be systematically evoked in front of any case of bilateral exophthalmos especially in an infectious context in order to avoid irrevesible vsion loss.

Surgical interventions for bilateral congenital cataract in children aged two years and under.

Surgical interventions for bilateral congenital cataract in children aged two years and under.

Impact of unilateral hearing loss in early development.

The purpose of this review is to provide an update on current literature as it relates to the impact of unilateral hearing loss for the pediatric population. Current studies further corroborate past research findings which reveal the potential consequences of unilateral hearing loss on spatial hearing, language, and neurocognitive functioning. Deficits among children with unilateral hearing loss may parallel those seen in children with bilateral hearing loss, further challenging historic views that hearing in one ear in childhood is sufficient for normal development. The potential deficiencies seen in children with unilateral hearing loss can be subtler than those seen with bilateral hearing loss, but may nonetheless also impact school performance, patient fatigue, parental stress, and quality of life. Early interventions within a sensitive period of development of the central auditory system may circumvent potential barriers in cognitive, academic, and psychosocial development. This review synthesizes the latest research on the impact of unilateral hearing loss in childhood and the role for possible interventions. The summarized information may serve to support the development of new guidelines for the evaluation and treatment of children with unilateral hearing loss.

How does age determine the development of human immune-mediated arthritis?

Does age substantially affect the emergence of human immune-mediated arthritis? Children do not usually develop immune-mediated articular inflammation during their first year of life. In patients with juvenile idiopathic arthritis, this apparent ‘immune privilege’ disintegrates, and chronic inflammation is associated with variable autoantibody signatures and patterns of disease that resemble adult arthritis phenotypes. Numerous mechanisms might be involved in this shift, including genetic and epigenetic predisposing factors, maturation of the immune system with a progressive modulation of putative tolerogenic controls, parallel development of microbial dysbiosis, accumulation of a pro-inflammatory burden driven by environmental exposures (the exposome) and comorbidity-related drivers. By exploring these mechanisms, we expand the discussion of three (not mutually exclusive) hypotheses on how these factors can contribute to the differences and similarities between the loss of immune tolerance in children and the development of established immune-mediated arthritis in adults. These three hypotheses relate to a critical window in genetics and epigenetics, immune maturation, and the accumulation of burden. The varied manifestation of the underlying mechanisms among individuals is only beginning to be clarified, but the establishment of a framework can facilitate the development of an integrated understanding of the pathogenesis of arthritis across all ages.

Possibility of Macrolides Causing Hearing Loss in Children—What Did You Say?

Possibility of Macrolides Causing Hearing Loss in Children—What Did You Say?

Association of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Children, Adolescents, and Young Adults

Prior publications have reported the sporadic development of sensorineural hearing loss (SNHL) after intravenous or high-dose macrolide therapy for adults with comorbid conditions, but investigations of the auditory effect of oral outpatient dosing for children, adolescents, and young adults have been limited. To determine whether broad-based outpatient use of oral macrolide therapy is associated with increased risk of pediatric SNHL through nationally representative analyses. A retrospective case-control study of 875 matched pairs of children, adolescents, and young adults was performed, matching on age, sex, and the time elapsed since prescription date. All eligible pediatric patients were included, with matched control participants from the TRICARE US military health insurance system who were evaluated between October 1, 2009, and September 30, 2014. Oral outpatient macrolide treatment compared with penicillin use among pediatric patients. The clinical outcome of interest was SNHL in children, adolescents, and young adults. Multivariable conditional logistic regression was used to compare the risk of prior macrolide exposure with penicillin exposure, adjusted for other risk factors and potential confounders. Four time frames between exposure and diagnosis were additionally assessed. There were 875 eligible matched pairs of children, adolescents, and young adults included. The mean (SD) age of the participants was 5.7 (4.9) years; 1082 participants were male (62%), 58 were Asian (3%), 254 were Black (15%), 1152 were White (66%), and 286 were of Native American and other (no further breakdown was available in the TRICARE database) race and ethnicity (16%). In multivariable analysis, participants who had SNHL had increased odds of having received a macrolide prescription compared with a penicillin prescription when all time frames from exposure were included (adjusted odds ratio, 1.31; 95% CI, 1.05-1.64). There were significantly higher odds of macrolide exposure than penicillin exposure when diagnosis and testing occurred more than 180 days after antibiotic exposure (adjusted odds ratio, 1.79; 95% CI, 1.23-2.60). In this case-control study of a nationally representative patient population, findings suggest that children, adolescents, and young adults with SNHL had increased odds of outpatient oral macrolide use compared with penicillin use, particularly when having received a diagnosis more than 180 days after exposure. Further study of the association of macrolides with SNHL in children, adolescents, and young adults is warranted.

Being Deaf in Mainstream Schools: The Effect of a Hearing Loss in Children's Playground Behaviors.

Naturalistic playground observations are a rich source of information when studying the social interactions of preschool children. On the playground, children can interact with their peers, explore different places and activities, and engage in different types of play. For deaf and hard of hearing (DHH) children, interactions at a playground can be more difficult because of the large number of auditory stimuli surrounding them. Constraints in the access to the social world on the playground might hamper DHH children’s interactions with their typically hearing (TH) peers, activities, and play. This pilot study aimed to examine the playground behaviors of preschool DHH children across three aspects: social levels, type of activities, and play choices. For this purpose, 12 preschool DHH children were observed during recess time, and their behaviors were coded and compared to their 85 TH peers. The preliminary findings indicate that DHH children spend less time in social interactions compared to their TH peers and that they still face difficulties when socially engaging with their TH peers. These findings suggest that interventions should focus on three aspects: the physical environment awareness of TH peers about communicating with DHH children, and the use of exercise play to facilitate social interactions between DHH children and their TH peers.