Significant efforts remain to be undertaken to achieve efficient separation of particulate matter. Devices widely used for this purpose are cyclone separators. This study investigates the pressure loss phenomena and flow structures within cyclone devices, aiming to elaborate and optimize their performance. Traditional cyclone models: (i) Muschelknautz, (ii) Stairmand, and (iii) PM1 Sharp Cut, are evaluated alongside the innovative vortex limiter cyclone (VL) to distinguish their advantages and limitations. The focus is on describing the relation between pressure loss and flow characteristics of the different cyclones with the same design separation diameter of 1μm. Empirical pressure loss correlations analyze how pressure losses vary within different cyclone devices. It was proven that predictions depend on cyclone size and operational parameters. Computational Fluid Dynamics (CFD) simulations further elucidate pressure loss mechanisms, highlighting the complexities inherent in modeling cyclonic behavior accurately. In conclusion, this study contributes to advancing the understanding of cyclone performance by elucidating the intricate interplay between pressure loss phenomena and flow structures. Such insights hold profound indications for optimizing cyclone separator design and operation in diverse industrial applications.