This article emphasizes the findings of comparative thermal enhancement in Casson fluid using bases fluid as blood and Xue and Yamada-Ota hybrid nano-structures model towards a 3D swirling plate. Nanofluid flow is a widely investigated topic in engineering and industry, particularly in the cooling of electronic devices. Its proven ability to save energy makes it a viable option for improving cooling systems and sustainability initiatives. Thermal energy incorporates solar radiation, Soret and heat sources while transportation of species happens utilizing activation energy and Dufour impact. It was estimated that the system (partial differential equation) is converted into Odes employing finite element methodology. Such a complicated model is resolved efficient method named as finite element method. By enhancing impacts of chemical reaction and Dufour numbers, mass diffusion is enhanced but opposite behavior is noticed in mass diffusion with the change of Schmidt number. By increasing values of Lorentz force and velocity field inclines. Further, thickness (MBLs) increase with variation of Lorentz force and Casson parameter.