Crystal structures of organic compounds with all intermolecular contacts longer than the sum of van der Waals radii can be classified as a loose state of solids. The survey of Cambridge Structural Database (CSD) revealed about 450 of such crystals. Specific features responsible for the loose arrangement are low magnitudes of electrostatic potential on the molecular surface and the concentric distribution of net atomic charges, reducing the contribution of electrostatic forces to the crystal cohesion interactions. Additionally, in the loose structures a partial mismatch between the requirement of molecular close-packing with electrostatic and specific directional interactions has been observed. Consequently, the cohesion forces are dominated by dispersion interactions, and their contribution is much larger compared to Coulombic and polarization energy. In the most loose compound presently deposited in the CSD, bis(trichlorosilyl)acetylene, the shortest of all contacts is by 0.256 A longer than the sum of v...