Multiport mini-channel thermosyphon with hydraulic diameters less than 2 mm undergoes a severe entrainment problem both in vapor and liquid regions, impeding the flow and affecting the performance characteristics. To address this issue, a novel multiport mini-channel loop thermosyphon (MPMC-LT) design is proposed. This design separates the vapor and liquid flow paths, reducing entrainment and enhancing the performance characteristics. Tests are conducted with heat loads ranging from 5 to 45W at four inclinations (0°, 30°, 60°, and 90°) relative to the horizontal plane. Results revealed that the MPMC-LT design extends the entrainment limit by 10.6 times compared to conventional designs, reducing the interaction between the vapor and condensed working fluid. Additionally, the total entropy and thermal resistance drops by 20.7 % and 19.9 %, respectively at an optimum inclination angle of 30°. It is also noted that the effective thermal conductivity at the optimal inclination is 5.8 times higher compared to the conventional multiport thermosyphon designs. The design effectivity uses the buoyancy, inertial and surface tension forces to reduce resistance in the fluid flow, thereby enhancing the heat transfer characteristics. These results highlight that MPMC-LT is a suitable thermal management device for power electronic systems.