Wireless and mobile devices and networks are an integral part of today’s life. With the advancement of technology, a large number of smart devices with advanced computational and communicational types of equipment are designed and developed. With these advancements, the availability of services over these devices is required to be of high quality for ensuring better experiences day by day. Thus, network performance improvement with minimum path loss and optimized packet delivery without loops is a major concern to integrate the existing network infrastructure with advanced and future networks. This work has designed a novel route deviation and optimization algorithm with simulation optimization and energy efficiency constraints. The simulation-optimization approach is considered to have minimum link losses and avoid the loop problem. Whereas, local and global simulation optimization processes are followed to identify the best possibilities in route identification in consideration with local and network environment settings. The proposed approach is statistically found to have a minimum error rate and optimizes the performance with computational and communicational overheads. In results, a minimum of 10 seconds and a maximum of 150 seconds are observed before a device using the proposed approach gets utilized fully. Thus, the proposed approach is very effective for link loss and loop problems in wireless sensor networks. Further, an improvement of 135 (approx.) is observed in the proposed approach.