We consider a diffuse interface model that describes the macro- and micro-phase separation processes of a polymer mixture. The resulting system consists of a Cahn–Hilliard equation and a Cahn–Hilliard–Oono type equation endowed with the singular Flory–Huggins potential. For the initial boundary value problem in a bounded smooth domain of [Formula: see text] ([Formula: see text]) with homogeneous Neumann boundary conditions for the phase functions as well as chemical potentials, we study the regularity and long-time behavior of global weak solutions in the off-critical case, that is, the mass is not conserved during the micro-phase separation of diblock copolymers. By investigating an auxiliary system with viscous regularizations, we show that every global weak solution regularizes instantaneously for [Formula: see text]. In two dimensions, we obtain the instantaneous strict separation property under a mild growth condition on the first derivative of potential functions near pure phases [Formula: see text], while in three dimensions, we establish the eventual strict separation property for sufficiently large time. Finally, we prove that every global weak solution converges to a single equilibrium as [Formula: see text].
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