Worldwide, breast cancer (BC) is the most common cancer among women. Natural plant compounds with anticancer potential can block BC biomarkers, but they must be chosen carefully to avoid adverse side effects. In this research, the interaction between the BC biomarkers and plant compounds from Dimocarpus Longan was studied using a molecular docking approach. Twenty plant constituents from longan and two target proteins considered involved in BC (1ERR: Estrogen receptor and 3D90: Progesterone receptor) were obtained from the PubChem database and RCSB Protein Data Bank (PDB) respectively. They were docked using the SwissDock server. Then, the drug-likeness of the plant compounds that demonstrated interaction was evaluated. The results show that 1ERR and 3D90 had the lowest binding affinity with the L-epicatechin at the value of -9.5 and -8.3 kcal/mol respectively. These proteins had the most stable interaction with their plant compounds. The toxicity prediction analysis revealed that L-epicatechin is not safe to use as a drug due to AMES toxicity. All of the ten compounds had low binding scores, indicating that they had good interactions. Therefore, α-terpineol was chosen to use as a safe drug. The findings of this study should aid pharmaceutical researchers in identifying longan-based medications.