Fault slip rates and recurrence intervals of large earthquakes for active faults are important parameters for better understanding active faults and assessing their seismic hazard. The Tanlu fault, located in the densely populated and economically developed area of eastern China is thought to be the source of the M 7 Anqiu earthquake in 70 BC, and M 8½ Tancheng earthquake in 1668. Understanding the recurrence interval of paleoearthquakes and fault slip rates for the Tancheng earthquake fault is critical for assessing the potential for seismic risk and assessment for the Tanlu fault. However, the only published study used several trenches and a single trench does not completely record the sequence of paleoearthquake events, leaving a large uncertainty of seismic hazard. GPS observations in North China show that there is no significant velocity gradient across the Tanlu fault, yet the long-term slip rate of the Tancheng segment of the fault is estimated to be significantly higher, up to 2 mm/a. Therefore, it is critical to conduct further research on the paleoearthquake history and slip rates of this fault segment to reconcile these contrasting results. In this study, we utilize aerial photographs and high-resolution satellite imagery, combined with field investigations of a surface rupture formed by the 1668 earthquake. The earthquake rupture is ~80 m long and ~2.5 m high, located in the Huaqiao village of northeastern Tancheng County. A gully across the rupture reveals a right lateral dislocation of approximately 36 m. We excavated two trenches on both sides of the rupture. Trench 1 reveals a positive flower structure and is consistent with a right lateral strike-slip fault with a thrust component consistent with the modern regional stress field. Trench 2 reveals a colluvial wedge formed by the latest paleoearthquake with a fine-grained deposit overlapping the colluvial wedge. The latest paleoearthquake should occur prior to deposition of the fine-grained deposit. AMS-14C radiocarbon dating was used to determine the age of the event and is approximately 12.8 +4.0/−3.7 ka, indicating a recurrence interval of large earthquakes greater than 10 ka, consistent with the results from other segments of the Tanlu fault. Combined with an average slip of ~9 m for the 1668 Tancheng earthquake, the dextral slip rate along the Tancheng earthquake fault since the end of the late Pleistocene is estimated to be 0.7 mm/a, consistent with low interseismic strain accumulation based on geodetic observations across the North China region.