Introduction: The development of the concept of a personalized approach to patients with deep vein thrombosis of the lower limbs(DVT),based on the choice of tactics for patients,depending on the characteristics of phenotype,characteristics of disease,is a new,unexplored and promising direction of research. Methods: We studied the results of treatment of 102 patients with DVT receiving conservative therapy by the prospective randomized study.The patients were divided into 3 groups.The first group consisted of 23 patients taking warfarin (22.5%),39 patients(38.2%)receiving dabigatran,40 patients receiving rivaroxaban (39.21%).Patients of all groups received anticoagulant therapy from the first day of the diagnosed disease for 6 months.The observation period was one year.In addition to anticoagulant therapy,patients received compression therapy with a 2nd compression class and venotonic drugs.The mean age of the patients was 57±3 years and there was no statistically significant difference in the groups.The average period from the onset of the disease to the start of the treatment was 5.6±4.8 days and also did not have a statistically significant difference in the compared groups.Patients were examined on 44 grounds.All the changing parameters were measured in dynamics and evaluated on the 1st, 4th and 7th days,and also at1,6 and 12 months from the start of treatment.The statistical programming language R [RCoreTeam (2017) was used for data processing.In the work,nonparametric statistics methods were used:Kraskel-Wallis test when comparing several groups,the Mann-Whitney-Wilcoxon test for comparison of two groups(with the Benjamin-Yekutil correction in the case of multiple comparisons).We also used the Friedman test,and the Fisher test was used to analyze the conjugacy tables.As additional analysis methods we used the solution trees,the RPART algorithm,cluster analysis and the fuzzy C algorithm. Results: After 1 year,72 patients were examined(16,31 and 25 patients taking warfarin,dabigatran and rivaroxaban respectively).Postthrombotic disease in the warfarin group was observed in 8 patients (50%),in the dabigatran group in 16 patients(51.6%),in the rivaroxaban group in 10 patients(38.5%).Factors directly influencing the unsatisfactory outcome of conservative treatment of DVT were:dynamics of venous insufficiency during 7 days of treatment(venous insufficiency rates on the scale of Villalta are more than 2.5 points for the 7th day of treatment,OR=6.9, 95% CI[1.63 42.51],Fisherexacttestp=.004),the age of the patient(the threshold was less than 47 years old(OR=5,95% CI [0.9 53.29],Fisherexacttestp = .049),type of drug used (bad results for Warfarin group),and patients with a high BMI(more than 30 kg/m2). Conclusion: 1.Using of rivaroxaban in contrast to the use of warfarin or dabigatran in the treatment of DVT leads to less probability of postthrombotic disease in 1 year of follow-up.2.Factors leading to unsatisfactory results of conservative treatment of DVT are: unsatisfactory response to conservative therapy for 7 days,BMI over 30 kg/m2,age less than 47 years,choosing of warfarin instead of new oral anticoagulants (dabigatran or rivaroxaban).3.The conducted studies have created the possibility of creating a mathematical algorithm for predicting the outcome of conservative treatment of DVT with a probability of 75%,which may allow us to further outline ways to improve the results of treatment of such patients on the basis of an individual approach to their treatment(see the figure).
Read full abstract